Concentration effect relationship of CYP3A inhibition by ritonavir in humans - Eichbaum, Christine; Cortese, Marianna; Blank, Antje; Burhenne, Jürgen; Mikus, Gerd (European journal of clinical pharmacology, 2013)
Keywords: Adult; Antiretroviral drugs; Area Under Curve; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug dosages; Enzymes; Female; HIV Protease Inhibitors - administration & dosage; HIV Protease Inhibitors - blood; HIV Protease Inhibitors - pharmacology; Humans; Male; Medical sciences; Midazolam - administration & dosage; Midazolam - blood; Midazolam - pharmacology; Middle Aged; Nontherapeutic Human Experimentation; Pharmacokinetics and Disposition; Pharmacology; Pharmacology. Drug treatments; Pharmacology/Toxicology; Prescription drugs; Ritonavir - administration & dosage; Ritonavir - blood; Ritonavir - pharmacology; Young Adult; CYP3A; Inhibition; Midazolam; Ritonavir; Human; Antiretroviral agent; Enzyme; Isozyme; Psychotropic; Cytochrome P450; Enzyme inhibitor; Hypnotic; Peptidases; Activity concentration relation; Benzodiazepine derivatives; Hydrolases; Antiviral; Sedative; Protease inhibitor