Manipulation of innate immune signaling pathways by SARS-CoV-2 non-structural proteins

• Published in: Frontiers in microbiology Vol. 13; p. 1027015
• Main Authors: Lu, Yongxu, Michel, Hendrik A., Wang, Pei-Hui, Smith, Geoffrey L.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 21.11.2022
• Subjects: innate immunity; IRF3; Microbiology; Nsp6; Orf6; Orf8; SARS-CoV-2; Orf8; NF-κB; SARS-CoV-2; IRF3; innate immunity; JAK-STAT; Orf6; Nsp6

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the current coronavirus disease 2019 (COVID-19) pandemic, induces an unbalanced immune response in the host. For instance, the production of type I interferon (IFN) and the response to it, which act as a front-line...