Alzheimer’s disease alters the transcriptomic profile of natural killer cells at single-cell resolution

• Published in: Frontiers in immunology Vol. 13; p. 1004885
• Main Authors: Qi, Caiyun, Liu, Fang, Zhang, Wenjun, Han, Yali, Zhang, Nan, Liu, Qiang, Li, Handong
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 02.11.2022
• Subjects: Alzheimer Disease - genetics; Alzheimer’s disease; CD56 Antigen - analysis; CD56 Antigen - genetics; cytotoxicity; Humans; Immunity, Innate; Immunology; innate immunity; Killer Cells, Natural; natural killer cell; single cell sequencing; Transcriptome; single cell sequencing; Alzheimer’s disease; innate immunity; natural killer cell; cytotoxicity

Alzheimer’s disease (AD) is the most common dementia without an effective cure at least partially due to incomplete understanding of the disease. Inflammation has emerged as a central player in the onset and progression of AD. As innate lymphoid cells, natural killer (NK) cells orchestrate the initi...