Angiopoietin-Like 2, a Circadian Gene, Improves Type 2 Diabetes Through Potentiation of Insulin Sensitivity in Mice Adipocytes

• Published in: Endocrinology (Philadelphia) Vol. 152; no. 7; pp. 2558 - 2567
• Main Authors: Kitazawa, Masashi, Nagano, Mamoru, Masumoto, Koh-hei, Shigeyoshi, Yasufumi, Natsume, Tohru, Hashimoto, Seiichi
• Format: Journal Article
• Language: English
• Published: Chevy Chase, MD Endocrine Society 01.07.2011
• Subjects: 3T3-L1 Cells; Adipocytes - cytology; Adipocytes - metabolism; Adipogenesis; Adiponectin - blood; Adiponectin - genetics; Adiponectin - metabolism; Angiopoietin-like Proteins; Angiopoietins - antagonists & inhibitors; Angiopoietins - genetics; Angiopoietins - metabolism; Angiopoietins - therapeutic use; Animals; Biological and medical sciences; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Chronobiology; Circadian Rhythm; Circadian Rhythm Signaling Peptides and Proteins - antagonists & inhibitors; Circadian Rhythm Signaling Peptides and Proteins - genetics; Circadian Rhythm Signaling Peptides and Proteins - metabolism; Circadian Rhythm Signaling Peptides and Proteins - therapeutic use; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Hypoglycemic Agents - therapeutic use; Insulin Resistance; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Receptors, Leptin - genetics; Receptors, Leptin - metabolism; Recombinant Proteins - therapeutic use; RNA, Messenger - metabolism; RNA, Small Interfering; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: endocrinology; Endocrinopathy; Type 2 diabetes; Adipocyte; Pancreatic hormone; Rodentia; Metabolic diseases; Biological rhythm; Circadian rhythm; Insulin; Vertebrata; Sensitivity; Mammalia; Gene; Mouse; Animal

Angiopoietin-like (Angptl)2, a member of the Angptl protein family, is predominantly secreted from adipose tissue and the heart. Here, we demonstrate that the expression of Angptl2 in epididymal adipose tissue of C57BL/6J mice shows pulsatility and circadian rhythmicity and that the rhythmicity was...