Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen

• Published in: Clinical toxicology (Philadelphia, Pa.) Vol. 60; no. 2; pp. 221 - 230
• Main Authors: Sonn, Brandon J., Heard, Kennon J., Heard, Susan M., D'Alessandro, Angelo, Reynolds, Kate M., Dart, Richard C., Rumack, Barry H., Monte, Andrew A.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.02.2022
• Subjects: Acetaminophen - poisoning; Alanine Transaminase; Biomarkers; Chemical and Drug Induced Liver Injury - diagnosis; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - etiology; DILI; Drug Overdose; glutathione metabolism; Humans; Liver - metabolism; ornithine; Urea cycle; ornithine; DILI; Urea cycle; glutathione metabolism; alanine transaminase

Drug induced liver injury (DILI) remains a prominent global issue and acetaminophen (APAP) overdose represents a common cause of hepatic injury and DILI. Transient alanine aminotransferase (ALT) elevations have been documented while adhering to recommended daily dosing. However, no metabolites have...