Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4

• Published in: JCI insight Vol. 8; no. 4
• Main Authors: Li, Zhuang, Zhou, Enchen, Liu, Cong, Wicks, Hope, Yildiz, Sena, Razack, Farhana, Ying, Zhixiong, Kooijman, Sander, Koonen, Debby PY, Heijink, Marieke, Kostidis, Sarantos, Giera, Martin, Sanders, Ingrid MJG, Kuijper, Ed J, Smits, Wiep Klaas, van Dijk, Ko Willems, Rensen, Patrick CN, Wang, Yanan
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 22.02.2023; American Society for Clinical investigation
• Subjects: Animals; Butyrates - adverse effects; Cell Proliferation; Endocrinology; Humans; Metabolic Syndrome; Mice; Microbiology; Obesity - metabolism; RNA, Ribosomal, 16S; Weight Gain; Microbiology; Obesity; Endocrinology

Short-chain fatty acids, including butyrate, have multiple metabolic benefits in individuals who are lean but not in individuals with metabolic syndrome, with the underlying mechanisms still being unclear. We aimed to investigate the role of gut microbiota in the induction of metabolic benefits of d...