A trial of midazolam vs diphenhydramine in prophylaxis of metoclopramide-induced akathisia

• Published in: The American journal of emergency medicine Vol. 30; no. 1; pp. 84 - 91
• Main Authors: Erdur, Bulent, MD, Tura, Pinar, MD, Aydin, Berrin, MD, Ozen, Mert, MD, Ergin, Ahmet, MD, PhD, MPH, Parlak, Ismet, MD, Kabay, Burhan, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2012; Elsevier; Elsevier Limited
• Subjects: Adult; Akathisia, Drug-Induced - prevention & control; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Antiemetics - adverse effects; Antiemetics - therapeutic use; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Confidence intervals; Diphenhydramine - therapeutic use; Dopamine; Double-Blind Method; Emergency; Emergency medical care; Fallowing; Female; Headaches; Humans; Hypnotics and Sedatives - therapeutic use; Intensive care medicine; Male; Medical sciences; Medical treatment; Metoclopramide - adverse effects; Metoclopramide - therapeutic use; Midazolam - therapeutic use; Nausea - drug therapy; Pharmacology. Drug treatments; Prophylaxis; Restless legs syndrome; Severity of Illness Index; Studies; Treatment Outcome; Nervous system diseases; Intensive care; Psychotropic; Dopamine antagonist; Hypnotic; Diphenhydramine; Antihistaminic; Metoclopramide; Involuntary movement; Cerebral disorder; Prevention; D2 Dopamine receptor; Central nervous system disease; Benzamide derivatives; Benzodiazepine derivatives; Akathisia; Midazolam; Sedative; H1 Histamine receptor; Neurological disorder; Antiemetic; Resuscitation; Extrapyramidal syndrome

Abstract Study Objective The study aimed to evaluate the effects of midazolam and diphenhydramine for the prevention of metoclopramide-induced akathisia. Methods This randomized, double-blind, and controlled trial aimed to investigate coadministered midazolam vs diphenhydramine in the prophylaxis of...