Effect of Water-Based Microencapsulation on Protection against EDIM Rotavirus Challenge in Mice

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Published inJournal of Virology Vol. 72; no. 5; pp. 3859 - 3862
Main Authors Moser, C A, Speaker, T J, Offit, P A
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.05.1998
Subjects
Alginates
Animal Viruses
Animals
Antibodies, Viral - biosynthesis
Biocompatible Materials
Cell Line
Cercopithecus aethiops
Disease Models, Animal
Drug Compounding
Female
Glucuronic Acid
Hexuronic Acids
Immunoglobulin A - biosynthesis
Intestine, Small - cytology
Intestine, Small - immunology
Lymphocytes - immunology
Mice
Mice, Inbred BALB C
Rotavirus - immunology
Rotavirus Infections - immunology
Rotavirus Infections - prevention & control
Time Factors
Vaccination - methods
Water
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We determined the capacity of microcapsules formed by the combination of sodium alginate, an aqueous anionic polymer, and spermine hydrochloride, an aqueous cationic amine, to enhance protection against rotavirus challenge in mice. Adult BALB/c mice were orally inoculated with either free or microencapsulated rotavirus (simian rotavirus strain RRV) and challenged 6 or 16 weeks later with murine rotavirus strain EDIM. Virus-specific humoral immune responses were determined at the time of challenge and 4 days after challenge by intestinal fragment culture. We found that spermine-alginate microcapsules enhanced protection against challenge 16 weeks after immunization but not 6 weeks after immunization. Quantities of virus-specific immunoglobulin A produced by small intestinal lamina propria lymphocytes were correlated with the degree of protection against challenge afforded by spermine-alginate microcapsules. Possible mechanisms by which microcapsules enhance protection against rotavirus challenge are discussed.
ABSTRACT We determined the capacity of microcapsules formed by the combination of sodium alginate, an aqueous anionic polymer, and spermine hydrochloride, an aqueous cationic amine, to enhance protection against rotavirus challenge in mice. Adult BALB/c mice were orally inoculated with either free or microencapsulated rotavirus (simian rotavirus strain RRV) and challenged 6 or 16 weeks later with murine rotavirus strain EDIM. Virus-specific humoral immune responses were determined at the time of challenge and 4 days after challenge by intestinal fragment culture. We found that spermine-alginate microcapsules enhanced protection against challenge 16 weeks after immunization but not 6 weeks after immunization. Quantities of virus-specific immunoglobulin A produced by small intestinal lamina propria lymphocytes were correlated with the degree of protection against challenge afforded by spermine-alginate microcapsules. Possible mechanisms by which microcapsules enhance protection against rotavirus challenge are discussed.
Author Charlotte A. Moser
Tully J. Speaker
Paul A. Offit
AuthorAffiliation Section of Infectious Diseases, The Children’s Hospital of Philadelphia, 1 University of Pennsylvania School of Medicine, 3 and Wistar Institute of Anatomy and Biology, 4 Philadelphia, Pennsylvania 19104, and Temple University School of Pharmacy, Philadelphia, Pennsylvania 19140 2
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Cites_doi 10.1093/infdis/171.5.1334
10.1016/S0264-410X(97)00106-0
10.4049/jimmunol.154.2.536
10.1016/S0264-410X(96)00026-6
10.1006/viro.1994.1463
10.1016/0166-0934(83)90020-4
10.1093/infdis/172.3.870
10.1084/jem.177.5.1299
10.1016/0264-410X(94)90003-5
10.1016/0042-6822(62)90290-8
10.1128/jvi.65.3.1318-1324.1991
10.1128/cdli.1.6.722-728.1994
10.1128/JVI.72.2.1108-1114.1998
10.1016/0168-3659(94)90026-4
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Corresponding author. Mailing address: Section of Infectious Diseases, The Children’s Hospital of Philadelphia, Abramson Research Center, Rm. 1205A, 34th St. and Civic Center Blvd., Philadelphia, PA 19104. Phone: (215) 590-5152 or (215) 590-2186. Fax: (215) 590-2025. E-mail: Moser@email.chop.edu.
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References 14468055 - Virology. 1962 Feb;16:147-51
6204794 - Clin Exp Immunol. 1984 Jun;56(3):515-23
8961511 - Vaccine. 1996 Sep;14(13):1235-8
9364681 - Vaccine. 1997 Nov;15(16):1767-72
9445006 - J Virol. 1998 Feb;72(2):1108-14
9413108 - Vaccine. 1997 Dec;15(17-18):1959-62
8303941 - Vaccine. 1994 Jan;12(1):5-11
2731430 - Curr Top Microbiol Immunol. 1989;146:59-66
1847457 - J Virol. 1991 Mar;65(3):1318-24
6311856 - J Virol Methods. 1983 Jul;7(1):29-40
7529278 - J Immunol. 1995 Jan 15;154(2):536-44
9632536 - Microb Pathog. 1998 Jun;24(6):327-31
1879878 - Immunology. 1991 Jul;73(3):281-6
8478609 - J Exp Med. 1993 May 1;177(5):1299-307
7658086 - J Infect Dis. 1995 Sep;172(3):870-4
8556527 - Clin Diagn Lab Immunol. 1994 Nov;1(6):722-8
7751713 - J Infect Dis. 1995 May;171(5):1334-8
8030269 - Virology. 1994 Aug 15;203(1):134-43
e_1_3_2_15_2
e_1_3_2_8_2
e_1_3_2_16_2
e_1_3_2_7_2
e_1_3_2_17_2
e_1_3_2_18_2
e_1_3_2_19_2
e_1_3_2_20_2
Eldridge J. H. (e_1_3_2_4_2) 1989; 146
e_1_3_2_10_2
e_1_3_2_11_2
Reed L. J. (e_1_3_2_21_2) 1938; 27
e_1_3_2_22_2
e_1_3_2_12_2
e_1_3_2_3_2
e_1_3_2_13_2
e_1_3_2_2_2
e_1_3_2_14_2
Liu L. M. (e_1_3_2_9_2) 1991; 73
Issekutz T. B. (e_1_3_2_6_2) 1984; 56
Guery J. C. (e_1_3_2_5_2) 1995; 154
References_xml – ident: e_1_3_2_2_2
  doi: 10.1093/infdis/171.5.1334
– ident: e_1_3_2_15_2
  doi: 10.1016/S0264-410X(97)00106-0
– volume: 154
  start-page: 536
  year: 1995
  ident: e_1_3_2_5_2
  article-title: Dendritic cells are the most efficient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.154.2.536
  contributor:
    fullname: Guery J. C.
– volume: 56
  start-page: 515
  year: 1984
  ident: e_1_3_2_6_2
  article-title: Kinetics of cytotoxic lymphocytes in efferent lymph from single lymph nodes following immunization with vaccinia virus
  publication-title: Clin. Exp. Immunol.
  contributor:
    fullname: Issekutz T. B.
– ident: e_1_3_2_14_2
  doi: 10.1016/S0264-410X(96)00026-6
– ident: e_1_3_2_19_2
  doi: 10.1006/viro.1994.1463
– ident: e_1_3_2_20_2
– volume: 73
  start-page: 281
  year: 1991
  ident: e_1_3_2_9_2
  article-title: Lymph-borne (veiled) dendritic cells can acquire and present intestinally administered antigens
  publication-title: Immunology
  contributor:
    fullname: Liu L. M.
– ident: e_1_3_2_18_2
  doi: 10.1016/0166-0934(83)90020-4
– ident: e_1_3_2_8_2
  doi: 10.1093/infdis/172.3.870
– ident: e_1_3_2_10_2
  doi: 10.1084/jem.177.5.1299
– ident: e_1_3_2_13_2
  doi: 10.1016/0264-410X(94)90003-5
– ident: e_1_3_2_3_2
– ident: e_1_3_2_12_2
  doi: 10.1016/0042-6822(62)90290-8
– ident: e_1_3_2_17_2
  doi: 10.1128/jvi.65.3.1318-1324.1991
– ident: e_1_3_2_7_2
  doi: 10.1128/cdli.1.6.722-728.1994
– ident: e_1_3_2_11_2
– volume: 27
  start-page: 493
  year: 1938
  ident: e_1_3_2_21_2
  article-title: A simple method of estimating fifty per cent endpoints
  publication-title: Am. J. Hyg.
  contributor:
    fullname: Reed L. J.
– volume: 146
  start-page: 59
  year: 1989
  ident: e_1_3_2_4_2
  article-title: Biodegradable microspheres: vaccine delivery system for oral immunization
  publication-title: Curr. Top. Microbiol. Immunol.
  contributor:
    fullname: Eldridge J. H.
– ident: e_1_3_2_16_2
  doi: 10.1128/JVI.72.2.1108-1114.1998
– ident: e_1_3_2_22_2
  doi: 10.1016/0168-3659(94)90026-4
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We determined the capacity of microcapsules formed by the combination of sodium alginate, an aqueous anionic polymer, and spermine hydrochloride, an aqueous...
ABSTRACT We determined the capacity of microcapsules formed by the combination of sodium alginate, an aqueous anionic polymer, and spermine hydrochloride, an...
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SubjectTerms Alginates
Animal Viruses
Animals
Antibodies, Viral - biosynthesis
Biocompatible Materials
Cell Line
Cercopithecus aethiops
Disease Models, Animal
Drug Compounding
Female
Glucuronic Acid
Hexuronic Acids
Immunoglobulin A - biosynthesis
Intestine, Small - cytology
Intestine, Small - immunology
Lymphocytes - immunology
Mice
Mice, Inbred BALB C
Rotavirus - immunology
Rotavirus Infections - immunology
Rotavirus Infections - prevention & control
Time Factors
Vaccination - methods
Water
Title Effect of Water-Based Microencapsulation on Protection against EDIM Rotavirus Challenge in Mice
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