Changes in the transcriptional profile in response to overexpression of the osteopontin-c splice isoform in ovarian (OvCar-3) and prostate (PC-3) cancer cell lines

• Published in: BMC cancer Vol. 14; no. 1; p. 433
• Main Authors: Tilli, Tatiana M, Bellahcène, Akeila, Castronovo, Vincent, Gimba, Etel R P
• Format: Journal Article Web Resource
• Language: English
• Published: England BioMed Central 13.06.2014
• Subjects: Alternative Splicing; angiogenesis; Biochemistry, biophysics & molecular biology; Biochimie, biophysique & biologie moléculaire; Cell Adhesion; Cell culture; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cloning; Endothelial Cells - metabolism; Female; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Human health sciences; Humans; Kinases; Life sciences; Male; Medical prognosis; Metastasis; Oncologie; Oncology; osteopontin; Osteopontin - genetics; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; PCR array; Plasmids; Prostate cancer; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Proteins; RNA Isoforms; Sciences de la santé humaine; Sciences du vivant; splicing isoform; Transcriptome; Tumors

Especially in human tumor cells, the osteopontin (OPN) primary transcript is subject to alternative splicing, generating three isoforms termed OPNa, OPNb and OPNc. We previously demonstrated that the OPNc splice variant activates several aspects of the progression of ovarian and prostate cancers. Th...