Rearing behaviour in the mouse behavioural pattern monitor distinguishes the effects of psychedelics from those of lisuride and TBG

• Published in: Frontiers in pharmacology Vol. 14; p. 1021729
• Main Authors: Chen, Yahong, Liu, Junhong, Yao, Yishan, Yan, Haitao, Su, Ruibin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 16.02.2023
• Subjects: 5-HT2A receptor; exploratory rearing; lisuride; locomotor activity; Pharmacology; psychedelics; TBG; psychedelics; 5-HT2A receptor; exploratory rearing; lisuride; TBG; locomotor activity; jump

Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor...