Rearing behaviour in the mouse behavioural pattern monitor distinguishes the effects of psychedelics from those of lisuride and TBG
Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor...
Saved in:
| Published in | Frontiers in pharmacology Vol. 14; p. 1021729 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
16.02.2023
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor activity and exploratory behaviour using the mouse Behavioural Pattern Monitor (BPM). DOM, mescaline, and psilocin reduced locomotor activity at high doses and influenced rearings, an exploratory behaviour, in a characteristic inverted U-shaped dose-response function. Pretreatment with the selective 5-HT
2A
antagonist M100907 reversed the drug-induced alterations in locomotor activity, rearings, and jumps after systemic administration of DOM at low doses. However, holepoking at the full range of doses tested was not blocked by M100907. Administration of the hallucinogenic 5-HT
2A
agonist 25CN-NBOH induced striking similarities in response to that to psychedelics; these alterations were significantly diminished by M100907, whereas the putatively non-hallucinogenic 5-HT
2A
agonist TBG did not affect locomotor activity, rearings, or jumps at the most effective doses. The nonhallucinogenic 5-HT
2A
agonist lisuride failed to increase rearing. The results of these experiments provide strong evidence that DOM-elicited increases in rearing are due to mediation by the 5-HT
2A
receptor. Finally, discriminant analysis was able to distinguish all four psychedelics from lisuride and TBG based on behavioural performance alone. Thus, increased rearing in mice could provide additional evidence of behavioural differences between hallucinogenic and nonhallucinogenic 5-HT
2A
agonists. |
|---|---|
| AbstractList | Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor activity and exploratory behaviour using the mouse Behavioural Pattern Monitor (BPM). DOM, mescaline, and psilocin reduced locomotor activity at high doses and influenced rearings, an exploratory behaviour, in a characteristic inverted U-shaped dose-response function. Pretreatment with the selective 5-HT
2A
antagonist M100907 reversed the drug-induced alterations in locomotor activity, rearings, and jumps after systemic administration of DOM at low doses. However, holepoking at the full range of doses tested was not blocked by M100907. Administration of the hallucinogenic 5-HT
2A
agonist 25CN-NBOH induced striking similarities in response to that to psychedelics; these alterations were significantly diminished by M100907, whereas the putatively non-hallucinogenic 5-HT
2A
agonist TBG did not affect locomotor activity, rearings, or jumps at the most effective doses. The nonhallucinogenic 5-HT
2A
agonist lisuride failed to increase rearing. The results of these experiments provide strong evidence that DOM-elicited increases in rearing are due to mediation by the 5-HT
2A
receptor. Finally, discriminant analysis was able to distinguish all four psychedelics from lisuride and TBG based on behavioural performance alone. Thus, increased rearing in mice could provide additional evidence of behavioural differences between hallucinogenic and nonhallucinogenic 5-HT
2A
agonists. Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor activity and exploratory behaviour using the mouse Behavioural Pattern Monitor (BPM). DOM, mescaline, and psilocin reduced locomotor activity at high doses and influenced rearings, an exploratory behaviour, in a characteristic inverted U-shaped dose-response function. Pretreatment with the selective 5-HT2A antagonist M100907 reversed the drug-induced alterations in locomotor activity, rearings, and jumps after systemic administration of DOM at low doses. However, holepoking at the full range of doses tested was not blocked by M100907. Administration of the hallucinogenic 5-HT2A agonist 25CN-NBOH induced striking similarities in response to that to psychedelics; these alterations were significantly diminished by M100907, whereas the putatively non-hallucinogenic 5-HT2A agonist TBG did not affect locomotor activity, rearings, or jumps at the most effective doses. The nonhallucinogenic 5-HT2A agonist lisuride failed to increase rearing. The results of these experiments provide strong evidence that DOM-elicited increases in rearing are due to mediation by the 5-HT2A receptor. Finally, discriminant analysis was able to distinguish all four psychedelics from lisuride and TBG based on behavioural performance alone. Thus, increased rearing in mice could provide additional evidence of behavioural differences between hallucinogenic and nonhallucinogenic 5-HT2A agonists.Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor activity and exploratory behaviour using the mouse Behavioural Pattern Monitor (BPM). DOM, mescaline, and psilocin reduced locomotor activity at high doses and influenced rearings, an exploratory behaviour, in a characteristic inverted U-shaped dose-response function. Pretreatment with the selective 5-HT2A antagonist M100907 reversed the drug-induced alterations in locomotor activity, rearings, and jumps after systemic administration of DOM at low doses. However, holepoking at the full range of doses tested was not blocked by M100907. Administration of the hallucinogenic 5-HT2A agonist 25CN-NBOH induced striking similarities in response to that to psychedelics; these alterations were significantly diminished by M100907, whereas the putatively non-hallucinogenic 5-HT2A agonist TBG did not affect locomotor activity, rearings, or jumps at the most effective doses. The nonhallucinogenic 5-HT2A agonist lisuride failed to increase rearing. The results of these experiments provide strong evidence that DOM-elicited increases in rearing are due to mediation by the 5-HT2A receptor. Finally, discriminant analysis was able to distinguish all four psychedelics from lisuride and TBG based on behavioural performance alone. Thus, increased rearing in mice could provide additional evidence of behavioural differences between hallucinogenic and nonhallucinogenic 5-HT2A agonists. Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor activity and exploratory behaviour using the mouse Behavioural Pattern Monitor (BPM). DOM, mescaline, and psilocin reduced locomotor activity at high doses and influenced rearings, an exploratory behaviour, in a characteristic inverted U-shaped dose-response function. Pretreatment with the selective 5-HT2A antagonist M100907 reversed the drug-induced alterations in locomotor activity, rearings, and jumps after systemic administration of DOM at low doses. However, holepoking at the full range of doses tested was not blocked by M100907. Administration of the hallucinogenic 5-HT2A agonist 25CN-NBOH induced striking similarities in response to that to psychedelics; these alterations were significantly diminished by M100907, whereas the putatively non-hallucinogenic 5-HT2A agonist TBG did not affect locomotor activity, rearings, or jumps at the most effective doses. The nonhallucinogenic 5-HT2A agonist lisuride failed to increase rearing. The results of these experiments provide strong evidence that DOM-elicited increases in rearing are due to mediation by the 5-HT2A receptor. Finally, discriminant analysis was able to distinguish all four psychedelics from lisuride and TBG based on behavioural performance alone. Thus, increased rearing in mice could provide additional evidence of behavioural differences between hallucinogenic and nonhallucinogenic 5-HT2A agonists. Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their effects and mechanisms using preclinical models. Here, we examined the effects of phenylalkylamine and indoleamine psychedelics on locomotor activity and exploratory behaviour using the mouse Behavioural Pattern Monitor (BPM). DOM, mescaline, and psilocin reduced locomotor activity at high doses and influenced rearings, an exploratory behaviour, in a characteristic inverted U-shaped dose-response function. Pretreatment with the selective 5-HT antagonist M100907 reversed the drug-induced alterations in locomotor activity, rearings, and jumps after systemic administration of DOM at low doses. However, holepoking at the full range of doses tested was not blocked by M100907. Administration of the hallucinogenic 5-HT agonist 25CN-NBOH induced striking similarities in response to that to psychedelics; these alterations were significantly diminished by M100907, whereas the putatively non-hallucinogenic 5-HT agonist TBG did not affect locomotor activity, rearings, or jumps at the most effective doses. The nonhallucinogenic 5-HT agonist lisuride failed to increase rearing. The results of these experiments provide strong evidence that DOM-elicited increases in rearing are due to mediation by the 5-HT receptor. Finally, discriminant analysis was able to distinguish all four psychedelics from lisuride and TBG based on behavioural performance alone. Thus, increased rearing in mice could provide additional evidence of behavioural differences between hallucinogenic and nonhallucinogenic 5-HT agonists. |
| Author | Chen, Yahong Liu, Junhong Yan, Haitao Yao, Yishan Su, Ruibin |
| AuthorAffiliation | State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Key Laboratory of Neuropsychopharmacology , Beijing Institute of Pharmacology and Toxicology , Beijing , China |
| AuthorAffiliation_xml | – name: State Key Laboratory of Toxicology and Medical Countermeasures , Beijing Key Laboratory of Neuropsychopharmacology , Beijing Institute of Pharmacology and Toxicology , Beijing , China |
| Author_xml | – sequence: 1 givenname: Yahong surname: Chen fullname: Chen, Yahong – sequence: 2 givenname: Junhong surname: Liu fullname: Liu, Junhong – sequence: 3 givenname: Yishan surname: Yao fullname: Yao, Yishan – sequence: 4 givenname: Haitao surname: Yan fullname: Yan, Haitao – sequence: 5 givenname: Ruibin surname: Su fullname: Su, Ruibin |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36874002$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kstuFDEQRS0URMKQH2CBvGQzgx_dfmyQIIIQKRISCmvL7S5PO-ppD7Y7Utb5cTyPQMICb2xV3XtKKt_X6GSKEyD0lpIV50p_8NvBphUjjK8oYVQy_QKdUSH4UivKTp68T9F5zrekHq41F80rdMqFkg0h7Aw9_ACbwrTGHQz2LsQ54TDhMgDexDnD37Id8daWAmmqnSmUmHAfcqnWOeQB8t4D3oMrGUePt_neDdDDGFzGPsVNFcQKrK0x5DmFHrCdenzz-fINeuntmOH8eC_Qz69fbi6-La-_X15dfLpeukaoshRSdNoLD6zvnG-ZJp3jTdNT4a3rFBBhpRTcc61I1woCnrGeaaE87ZQnki_Q1YHbR3trtilsbLo30QazL8S0NjaV4EYwRErqqFWiJ6wRjHSaUsJbJoVSLa1rXKCPB9Z27jbQO5hKXdEz6PPOFAazjndGa6l421bA-yMgxV8z5GI2ITsYRztB3bxhVSY1bXlTpe-ezvoz5PEXq0AdBC7FnBN440KxJcTd6DAaSswuM2afGbPLjDlmplrZP9ZH-n9MvwEIeMeE |
| CitedBy_id | crossref_primary_10_1016_j_fgb_2023_103812 crossref_primary_10_3389_fnins_2024_1404009 crossref_primary_10_1007_s10571_023_01381_1 crossref_primary_10_1038_s41598_024_64410_z crossref_primary_10_3390_ijms25010241 crossref_primary_10_1523_JNEUROSCI_0015_24_2024 crossref_primary_10_1007_s00213_024_06635_4 crossref_primary_10_1021_acsptsci_3c00192 crossref_primary_10_3389_fmolb_2023_1233743 |
| Cites_doi | 10.1007/s00213-002-1141-z 10.1177/0269881110388326 10.1016/0163-1047(92)90192-7 10.7554/eLife.35082 10.1016/0031-9384(87)90231-9 10.1038/sj.npp.1300819 10.1093/cercor/bhx257 10.1016/s0028-3908(98)00078-1 10.1159/000119303 10.1523/JNEUROSCI.3007-12.2013 10.1016/0278-5846(85)90074-0 10.1021/jm000339w 10.1016/s0006-8993(96)00945-6 10.1515/revneuro.2006.17.1-2.111 10.1016/0006-8993(84)90585-7 10.1038/s41380-021-01159-1 10.1177/26331055211033847 10.1007/s00213-009-1718-x 10.1097/00001756-199812010-00024 10.1146/annurev.ps.39.020188.000355 10.1017/S1461145712001198 10.1111/j.1526-4610.1983.hed2303117.x 10.1016/0165-0270(90)90051-g 10.1037/0033-295x.108.3.483 10.1037//0735-7044.110.1.60 10.1016/j.neuropharm.2013.01.014 10.1016/j.neubiorev.2005.04.018 10.1016/j.cell.2020.03.020 10.1007/s00702-005-0386-1 10.1159/000118996 10.1074/mcp.M113.036558 10.1080/10253890.2018.1438405 10.1016/0166-4328(90)90104-m 10.1146/annurev.me.15.020164.001223 10.1007/7854_2016_466 10.1001/archgenpsychiatry.2009.58 10.1007/s00213-017-4771-x 10.1017/S0007114513000238 10.1016/s0896-6273(02)00653-0 10.1523/JNEUROSCI.18-13-05095.1998 10.1523/JNEUROSCI.23-26-08836.2003 10.1037/h0043788 10.1038/272278a0 10.1016/0091-3057(85)90096-6 10.1007/BF02246076 10.1016/j.neuron.2007.01.008 10.1124/jpet.102.039883 10.1186/s12974-022-02400-6 10.1016/j.neuropharm.2019.107933 10.1016/j.bbrc.2020.08.022 10.1126/science.7071600 10.1007/s00213-013-3006-z 10.1016/0165-0173(84)90018-3 10.1007/BF02244617 10.1016/s0028-3908(98)00188-9 10.1016/j.jns.2020.116715 10.1007/BF03349379 10.1038/nature06612 10.1038/npp.2009.29 10.1016/j.neuropharm.2011.01.017 10.1126/science.6612338 10.1016/S0893-133X(97)00164-4 10.1016/j.bbr.2003.11.004 10.1016/0014-2999(75)90278-2 10.1111/j.1526-4610.1977.hed1702054.x 10.1038/s41586-020-3008-z 10.1016/j.ejphar.2010.10.094 10.1007/s002130050585 10.1177/0269881116675512 10.1007/BF02246075 10.1038/sj.npp.1301161 10.1016/0014-2999(82)90349-1 10.1016/j.pharmthera.2003.11.002 |
| ContentType | Journal Article |
| Copyright | Copyright © 2023 Chen, Liu, Yao, Yan and Su. Copyright © 2023 Chen, Liu, Yao, Yan and Su. 2023 Chen, Liu, Yao, Yan and Su |
| Copyright_xml | – notice: Copyright © 2023 Chen, Liu, Yao, Yan and Su. – notice: Copyright © 2023 Chen, Liu, Yao, Yan and Su. 2023 Chen, Liu, Yao, Yan and Su |
| DBID | AAYXX CITATION NPM 7X8 5PM DOA |
| DOI | 10.3389/fphar.2023.1021729 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic CrossRef PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| DocumentTitleAlternate | Chen et al |
| EISSN | 1663-9812 |
| ExternalDocumentID | oai_doaj_org_article_0771c1a86d024620b911035276885199 PMC9978355 36874002 10_3389_fphar_2023_1021729 |
| Genre | Journal Article |
| GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E O5R O5S OK1 P2P PGMZT RNS RPM IAO IEA IHR IHW IPNFZ NPM RIG 7X8 5PM |
| ID | FETCH-LOGICAL-c468t-676b9f6fe2dbcf5290bc344d16facb8e06a7763f3980b560ef22d2968f1b8f073 |
| IEDL.DBID | M48 |
| ISSN | 1663-9812 |
| IngestDate | Wed Aug 27 01:28:59 EDT 2025 Thu Aug 21 18:38:28 EDT 2025 Fri Jul 11 06:47:57 EDT 2025 Thu Jan 02 22:52:29 EST 2025 Tue Jul 01 02:33:56 EDT 2025 Thu Apr 24 23:00:48 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | psychedelics 5-HT2A receptor exploratory rearing lisuride TBG locomotor activity jump |
| Language | English |
| License | Copyright © 2023 Chen, Liu, Yao, Yan and Su. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c468t-676b9f6fe2dbcf5290bc344d16facb8e06a7763f3980b560ef22d2968f1b8f073 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Adam Halberstadt, University of California, San Diego, United States Esa R. Korpi, University of Helsinki, Finland This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Reviewed by: Chenning Zhang, Beijing University of Chinese Medicine, China |
| OpenAccessLink | https://doaj.org/article/0771c1a86d024620b911035276885199 |
| PMID | 36874002 |
| PQID | 2783791534 |
| PQPubID | 23479 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_0771c1a86d024620b911035276885199 pubmedcentral_primary_oai_pubmedcentral_nih_gov_9978355 proquest_miscellaneous_2783791534 pubmed_primary_36874002 crossref_citationtrail_10_3389_fphar_2023_1021729 crossref_primary_10_3389_fphar_2023_1021729 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2023-02-16 |
| PublicationDateYYYYMMDD | 2023-02-16 |
| PublicationDate_xml | – month: 02 year: 2023 text: 2023-02-16 day: 16 |
| PublicationDecade | 2020 |
| PublicationPlace | Switzerland |
| PublicationPlace_xml | – name: Switzerland |
| PublicationTitle | Frontiers in pharmacology |
| PublicationTitleAlternate | Front Pharmacol |
| PublicationYear | 2023 |
| Publisher | Frontiers Media S.A |
| Publisher_xml | – name: Frontiers Media S.A |
| References | Dang (B13) 2022; 19 González-Maeso (B26) 2003; 23 White (B70) 1982; 216 Feenstra (B17) 1996; 742 Raffaelli (B59) 1983; 23 Egan (B15) 1998; 136 Perry (B55) 2009; 66 Gironi Carnevale (B21) 1990; 39 Montgomery (B47) 1955; 48 Ekman (B16) 1983; 221 van Enkhuizen (B66) 2013; 16 Halberstadt (B30) 2011; 61 Gonzalez-Maeso (B25) 2007; 53 Chi (B12) 2020; 411 Ohman (B53) 2001; 108 Fiorella (B19); 121 Ross (B61) 2016; 30 Halberstadt (B31) 2011; 25 Nutt (B52) 2020; 181 Halberstadt (B27) 2013; 227 Halberstadt (B28) 2018; 36 Zuckerman (B73) 1993; 28 Sturman (B65) 2018; 21 Huang (B37) 2011; 652 Lever (B43) 2006; 17 Pieri (B57) 1978; 272 Karaki (B38) 2014; 13 Preller (B58) 2018; 7 Sandner (B62) 1987; 39 Adams (B2) 1985; 9 Barrett (B4) 2018; 28 Banerjee (B3) 2020; 531 Leighty (B42) 2004; 153 Newman-Tancredi (B50) 2002; 303 Wing (B71) 1990; 100 Halberstadt (B32) 2013; 70 Di Scala (B14) 1984; 309 Pehek (B54) 2006; 31 Holohean (B36) 1982; 81 Benes (B5) 2006; 113 Fendt (B18) 2005; 29 González-Maeso (B24) 2008; 452 Mulder (B48) 1998; 18 Zuckerman (B74) 1996; 34 Glennon (B22) 1985; 23 Herrmann (B34) 1977; 17 Hollister (B35) 1964; 15 Millan (B46) 1998; 37 Silveira (B64) 1992; 57 Verde (B68) 1980; 3 Lu (B44) 2021; 26 Adam (B1) 2020; 167 Silveira (B63) 1988; 21 Vollenweider (B69) 1998; 9 Bertolucci-D'Angio (B6) 1990; 34 Cameron (B10) 2021; 589 Kolb (B39) 1984; 320 Marona-Lewicka (B45) 2002; 164 Risbrough (B60) 2006; 31 Halberstadt (B29) 2010; 208 Nestler (B49) 2002; 34 Blair (B7) 2000; 43 Blanchard (B8) 1988; 39 Halberstadt (B33) 2009; 34 Kometer (B40) 2013; 33 Krebs-Thomson (B41) 1998; 18 Nichols (B51) 2004; 101 Burns (B9) 1996; 110 Vekovischeva (B67) 2013; 110 Fiorella (B20); 121 Gobert (B23) 1999; 38 Yamamoto (B72) 1975; 32 Carhart-Harris (B11) 2018; 235 Peters (B56) 2021; 16 |
| References_xml | – volume: 164 start-page: 93 year: 2002 ident: B45 article-title: Re-Evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats publication-title: Psychopharmacology doi: 10.1007/s00213-002-1141-z – volume: 25 start-page: 1548 year: 2011 ident: B31 article-title: Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice publication-title: J. Psychopharmacol. doi: 10.1177/0269881110388326 – volume: 57 start-page: 226 year: 1992 ident: B64 article-title: Defense reaction elicited by microinjection of kainic acid into the medial hypothalamus of the rat: Antagonism by a GABAA receptor agonist publication-title: Behav. Neural. Biol. doi: 10.1016/0163-1047(92)90192-7 – volume: 7 start-page: e35082 year: 2018 ident: B58 article-title: Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor publication-title: ELife doi: 10.7554/eLife.35082 – volume: 39 start-page: 333 year: 1987 ident: B62 article-title: Mapping of jumping, rearing, squealing and switch-off behaviors elicited by periaqueductal gray stimulation in the rat publication-title: Physiol. Behav. doi: 10.1016/0031-9384(87)90231-9 – volume: 31 start-page: 265 year: 2006 ident: B54 article-title: Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300819 – volume: 28 start-page: 3939 year: 2018 ident: B4 article-title: Serotonin 2A receptor signaling underlies LSD-induced alteration of the neural response to dynamic changes in music publication-title: Cereb. cortex doi: 10.1093/cercor/bhx257 – volume: 37 start-page: 953 year: 1998 ident: B46 article-title: Serotonin (5-HT)2C receptors tonically inhibit dopamine (DA) and noradrenaline (NA), but not 5-HT, release in the frontal cortex in vivo publication-title: Neuropharmacology doi: 10.1016/s0028-3908(98)00078-1 – volume: 34 start-page: 125 year: 1996 ident: B74 article-title: The psychobiological model for impulsive unsocialized sensation seeking: A comparative approach publication-title: Neuropsychobiology doi: 10.1159/000119303 – volume: 33 start-page: 10544 year: 2013 ident: B40 article-title: Activation of serotonin 2A receptors underlies the psilocybin-induced effects on α oscillations, N170 visual-evoked potentials, and visual hallucinations publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.3007-12.2013 – volume: 9 start-page: 121 year: 1985 ident: B2 article-title: Effects of DOM and DMT in a proposed animal model of hallucinogenic activity publication-title: Prog. Neuro-psychopharmacology. Biol. Psychiatry. doi: 10.1016/0278-5846(85)90074-0 – volume: 43 start-page: 4701 year: 2000 ident: B7 article-title: Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines publication-title: J. Med. Chem. doi: 10.1021/jm000339w – volume: 21 start-page: 569 year: 1988 ident: B63 article-title: Defense reaction elicited by microinjection of kainic acid in the medial hypothalamus of the rat publication-title: Braz. J. Med. Biol. Res. – volume: 742 start-page: 17 year: 1996 ident: B17 article-title: Rapid sampling of extracellular dopamine in the rat prefrontal cortex during food consumption, handling and exposure to novelty publication-title: Brain Res. doi: 10.1016/s0006-8993(96)00945-6 – volume: 17 start-page: 111 year: 2006 ident: B43 article-title: Rearing on hind legs, environmental novelty, and the hippocampal formation publication-title: Rev. Neurosci. doi: 10.1515/revneuro.2006.17.1-2.111 – volume: 309 start-page: 205 year: 1984 ident: B14 article-title: Flight induced by infusion of bicuculline methiodide into periventricular structures publication-title: Brain Res. doi: 10.1016/0006-8993(84)90585-7 – volume: 26 start-page: 6237 year: 2021 ident: B44 article-title: An analog of psychedelics restores functional neural circuits disrupted by unpredictable stress publication-title: Mol. Psychiatry. doi: 10.1038/s41380-021-01159-1 – volume: 16 start-page: 26331055211033847 year: 2021 ident: B56 article-title: Engineering safer psychedelics for treating addiction publication-title: Neurosci. Insights. doi: 10.1177/26331055211033847 – volume: 208 start-page: 179 year: 2010 ident: B29 article-title: LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor publication-title: Psychopharmacology doi: 10.1007/s00213-009-1718-x – volume: 9 start-page: 3897 year: 1998 ident: B69 article-title: Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action publication-title: Neuroreport doi: 10.1097/00001756-199812010-00024 – volume: 39 start-page: 43 year: 1988 ident: B8 article-title: Ethoexperimental approaches to the biology of emotion publication-title: Annu. Rev. Psychol. doi: 10.1146/annurev.ps.39.020188.000355 – volume: 16 start-page: 1021 year: 2013 ident: B66 article-title: Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice publication-title: Int. J. Neuropsychopharmacol. doi: 10.1017/S1461145712001198 – volume: 23 start-page: 117 year: 1983 ident: B59 article-title: Lisuride in cluster headache publication-title: Headache doi: 10.1111/j.1526-4610.1983.hed2303117.x – volume: 34 start-page: 135 year: 1990 ident: B6 article-title: Mesocorticolimbic dopaminergic systems and emotional states publication-title: J. Neurosci. Methods. doi: 10.1016/0165-0270(90)90051-g – volume: 108 start-page: 483 year: 2001 ident: B53 article-title: Fears, phobias, and preparedness: Toward an evolved module of fear and fear learning publication-title: Psychol. Rev. doi: 10.1037/0033-295x.108.3.483 – volume: 110 start-page: 60 year: 1996 ident: B9 article-title: Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: Implication for limbic-striatal interactions publication-title: Behav. Neurosci. doi: 10.1037//0735-7044.110.1.60 – volume: 70 start-page: 218 year: 2013 ident: B32 article-title: Role of the 5-HT₂A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2013.01.014 – volume: 29 start-page: 1145 year: 2005 ident: B18 article-title: TMT-induced autonomic and behavioral changes and the neural basis of its processing publication-title: Neurosci. Biobehav. Rev. doi: 10.1016/j.neubiorev.2005.04.018 – volume: 181 start-page: 24 year: 2020 ident: B52 article-title: Psychedelic psychiatry's brave new world publication-title: Cell doi: 10.1016/j.cell.2020.03.020 – volume: 113 start-page: 87 year: 2006 ident: B5 article-title: Lisuride treatment of restless legs syndrome: First studies with monotherapy in de novo patients and in combination with levodopa in advanced disease publication-title: J. Neural Transm. doi: 10.1007/s00702-005-0386-1 – volume: 28 start-page: 30 year: 1993 ident: B73 article-title: P-impulsive sensation seeking and its behavioral, psychophysiological and biochemical correlates publication-title: Neuropsychobiology doi: 10.1159/000118996 – volume: 13 start-page: 1273 year: 2014 ident: B38 article-title: Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists publication-title: Mol. Cell Proteomics. doi: 10.1074/mcp.M113.036558 – volume: 21 start-page: 443 year: 2018 ident: B65 article-title: Exploratory rearing: A context- and stress-sensitive behavior recorded in the open-field test publication-title: Stress doi: 10.1080/10253890.2018.1438405 – volume: 39 start-page: 187 year: 1990 ident: B21 article-title: Post-trial NMDA receptor allosteric blockade differentially influences habituation of behavioral responses to novelty in the rat publication-title: Behav. Brain Res. doi: 10.1016/0166-4328(90)90104-m – volume: 15 start-page: 203 year: 1964 ident: B35 article-title: Chemical psychoses publication-title: Annu. Rev. Med. doi: 10.1146/annurev.me.15.020164.001223 – volume: 36 start-page: 159 year: 2018 ident: B28 article-title: Effect of hallucinogens on unconditioned behavior publication-title: Curr. Top. Behav. Neurosci. doi: 10.1007/7854_2016_466 – volume: 66 start-page: 1072 year: 2009 ident: B55 article-title: A reverse-translational study of dysfunctional exploration in psychiatric disorders: From mice to men publication-title: Arch. Gen. Psychiatry. doi: 10.1001/archgenpsychiatry.2009.58 – volume: 235 start-page: 399 year: 2018 ident: B11 article-title: Psilocybin with psychological support for treatment-resistant depression: Six-month follow-up publication-title: Psychopharmacology doi: 10.1007/s00213-017-4771-x – volume: 110 start-page: 1336 year: 2013 ident: B67 article-title: The effects of native whey and alpha-lactalbumin on the social and individual behaviour of C57BL/6J mice publication-title: Br. J. Nutr. doi: 10.1017/S0007114513000238 – volume: 34 start-page: 13 year: 2002 ident: B49 article-title: Neurobiology of depression publication-title: Neuron doi: 10.1016/s0896-6273(02)00653-0 – volume: 18 start-page: 5095 year: 1998 ident: B48 article-title: Electrophysiology of the hippocampal and amygdaloid projections to the nucleus accumbens of the rat: Convergence, segregation, and interaction of inputs publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.18-13-05095.1998 – volume: 23 start-page: 8836 year: 2003 ident: B26 article-title: Transcriptome fingerprints distinguish hallucinogenic and nonhallucinogenic 5-hydroxytryptamine 2A receptor agonist effects in mouse somatosensory cortex publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.23-26-08836.2003 – volume: 48 start-page: 254 year: 1955 ident: B47 article-title: The relation between fear induced by novel stimulation and exploratory behavior publication-title: J. Comp. Physiol. Psychol. doi: 10.1037/h0043788 – volume: 272 start-page: 278 year: 1978 ident: B57 article-title: Effects of lisuride and LSD on cerebral monoamine systems and hallucinosis publication-title: Nature doi: 10.1038/272278a0 – volume: 23 start-page: 937 year: 1985 ident: B22 article-title: Mechanistic studies on DOM as a discriminative stimulus publication-title: Pharmacol. Biochem. Behav. doi: 10.1016/0091-3057(85)90096-6 – volume: 121 start-page: 364 ident: B19 article-title: The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion publication-title: Psychopharmacology doi: 10.1007/BF02246076 – volume: 53 start-page: 439 year: 2007 ident: B25 article-title: Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior publication-title: Neuron doi: 10.1016/j.neuron.2007.01.008 – volume: 303 start-page: 815 year: 2002 ident: B50 article-title: Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT(1) and 5-HT(2), receptor subtypes publication-title: J. Pharmacol. Exp. Ther. doi: 10.1124/jpet.102.039883 – volume: 19 start-page: 41 year: 2022 ident: B13 article-title: Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway publication-title: J. Neuroinflammation. doi: 10.1186/s12974-022-02400-6 – volume: 167 start-page: 107933 year: 2020 ident: B1 article-title: Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2019.107933 – volume: 531 start-page: 609 year: 2020 ident: B3 article-title: Differential signaling signatures evoked by DOI versus lisuride stimulation of the 5-HT(2A) receptor publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2020.08.022 – volume: 216 start-page: 535 year: 1982 ident: B70 article-title: Lysergic acid diethylamide (LSD) and lisuride: Differentiation of their neuropharmacological actions publication-title: Science doi: 10.1126/science.7071600 – volume: 227 start-page: 727 year: 2013 ident: B27 article-title: Characterization of the head-twitch response induced by hallucinogens in mice: Detection of the behavior based on the dynamics of head movement publication-title: Psychopharmacology doi: 10.1007/s00213-013-3006-z – volume: 320 start-page: 65 year: 1984 ident: B39 article-title: Functions of the frontal cortex of the rat: A comparative review publication-title: Brain Res. doi: 10.1016/0165-0173(84)90018-3 – volume: 100 start-page: 417 year: 1990 ident: B71 article-title: 5HT-2 mediation of acute behavioral effects of hallucinogens in rats publication-title: Psychopharmacology doi: 10.1007/BF02244617 – volume: 38 start-page: 315 year: 1999 ident: B23 article-title: Serotonin (5-HT)2A receptor activation enhances dialysate levels of dopamine and noradrenaline, but not 5-HT, in the frontal cortex of freely-moving rats publication-title: Neuropharmacology doi: 10.1016/s0028-3908(98)00188-9 – volume: 411 start-page: 116715 year: 2020 ident: B12 article-title: A review of emerging therapeutic potential of psychedelic drugs in the treatment of psychiatric illnesses publication-title: J. Neurol. Sci. doi: 10.1016/j.jns.2020.116715 – volume: 3 start-page: 405 year: 1980 ident: B68 article-title: Effectiveness of the dopamine agonist lisuride in the treatment of acromegaly and pathological hyperprolactinemic states publication-title: J. Endocrinol. Invest. doi: 10.1007/BF03349379 – volume: 452 start-page: 93 year: 2008 ident: B24 article-title: Identification of a serotonin/glutamate receptor complex implicated in psychosis publication-title: Nature doi: 10.1038/nature06612 – volume: 34 start-page: 1958 year: 2009 ident: B33 article-title: 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice publication-title: Neuropsychopharmacology doi: 10.1038/npp.2009.29 – volume: 61 start-page: 364 year: 2011 ident: B30 article-title: Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2011.01.017 – volume: 221 start-page: 1208 year: 1983 ident: B16 article-title: Autonomic nervous system activity distinguishes among emotions publication-title: Science doi: 10.1126/science.6612338 – volume: 18 start-page: 339 year: 1998 ident: B41 article-title: Effects of hallucinogens on locomotor and investigatory activity and patterns: Influence of 5-ht2a and 5-HT2C receptors publication-title: Neuropsychopharmacology doi: 10.1016/S0893-133X(97)00164-4 – volume: 153 start-page: 107 year: 2004 ident: B42 article-title: Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition publication-title: Behav. Brain Res. doi: 10.1016/j.bbr.2003.11.004 – volume: 32 start-page: 156 year: 1975 ident: B72 article-title: Behavioral effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rats and mice publication-title: Eur. J. Pharmacol. doi: 10.1016/0014-2999(75)90278-2 – volume: 17 start-page: 54 year: 1977 ident: B34 article-title: Clinical effectiveness of lisuride hydrogen maleate: A double-blind trial versus methysergide publication-title: Headache doi: 10.1111/j.1526-4610.1977.hed1702054.x – volume: 589 start-page: 474 year: 2021 ident: B10 article-title: A non-hallucinogenic psychedelic analogue with therapeutic potential publication-title: Nature doi: 10.1038/s41586-020-3008-z – volume: 652 start-page: 40 year: 2011 ident: B37 article-title: 5-HT(2A) and 5-HT(2C) receptor stimulation are differentially involved in the cortical dopamine efflux-Studied in 5-HT(2A) and 5-HT(2C) genetic mutant mice publication-title: Eur. J. Pharmacol. doi: 10.1016/j.ejphar.2010.10.094 – volume: 136 start-page: 409 year: 1998 ident: B15 article-title: Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors publication-title: Psychopharmacology doi: 10.1007/s002130050585 – volume: 30 start-page: 1165 year: 2016 ident: B61 article-title: Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: A randomized controlled trial publication-title: J. Psychopharmacol. doi: 10.1177/0269881116675512 – volume: 121 start-page: 357 ident: B20 article-title: Role of 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. II: Reassessment of LSD false positives publication-title: Psychopharmacology doi: 10.1007/BF02246075 – volume: 31 start-page: 2349 year: 2006 ident: B60 article-title: Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in mice publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1301161 – volume: 81 start-page: 595 year: 1982 ident: B36 article-title: Dopaminergic and serotonergic mediation of the discriminable effects of ergot alkaloids publication-title: Eur. J. Pharmacol. doi: 10.1016/0014-2999(82)90349-1 – volume: 101 start-page: 131 year: 2004 ident: B51 article-title: Hallucinogens publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2003.11.002 |
| SSID | ssj0000399364 |
| Score | 2.3657253 |
| Snippet | Psychedelics alter consciousness and may have potential for drug development. As psychedelics are likely therapeutically active, it is important to study their... |
| SourceID | doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 1021729 |
| SubjectTerms | 5-HT2A receptor exploratory rearing lisuride locomotor activity Pharmacology psychedelics TBG |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQT1wQUB6htDIS6oVGdRzHsY8taqmQQBXaSr1Z8YuutPKu9nHomT_OjJPuA1Vw4RrbseWZ8XxOZr4h5CNSRFnLYsnriCXMOlZqq1XZ2Cq0XRWUy6UTvn2XVzfi621zu1XqC2PCenrgfuNOWdtWruqU9OBNJGcWrBM5PAEmA1jQOXUPfN7WZSqfweh3peizZOAWpk_j7K5D_k9eI1tB1WPKjSfKhP2Pocw_gyW3vM_lc_JsgI30rF_uC_IkpJfk-Lrnnb4_oaNNGtXihB7T6w0j9f0--fUD9Bl8FB2S8ldzOk4UoB_Fi3_YPIYpZplwM0ELGvucejwE0s8Vxs4v8pghBIROI82x0sGHCUxLMVMFOkzhhdA0GS9W87EPtEuejs6_vCI3lxejz1flUH2hdEKqZSlbaXWUMXBvXWy4ZtbVQvhKxs5ZFZjsWjicYq0Vs4CbQuTccy1VrKyKcHK8JntpmsJbQpVshBBOK-essLzWAUAjQD_QEe8l8wWpHiRh3EBNjhUyJgauKCg9k6VnUHpmkF5BPq3HzHpijr_2PkcBr3siqXZ-AKpmBlUz_1K1gnx4UA8DRoh_VroUQE4Gy5W0GpyHKMibXl3WU9USqx4yXpB2R5F21rLbksZ3mehb5-9yzbv_sfgD8hQ3BAPOK_me7C3nq3AIeGppj7Lp_AaFHx1B priority: 102 providerName: Directory of Open Access Journals |
| Title | Rearing behaviour in the mouse behavioural pattern monitor distinguishes the effects of psychedelics from those of lisuride and TBG |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/36874002 https://www.proquest.com/docview/2783791534 https://pubmed.ncbi.nlm.nih.gov/PMC9978355 https://doaj.org/article/0771c1a86d024620b911035276885199 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1NbxMxELVKuXBBfJMClZFQL3Rh1-v12geEKKJUSEUVSqTerPVXGynahE0ikTN_nBmvkxBUENe1104yM37PzvgNIa9QIsqYPGSsDFjCrMkzZZTMKlP4uim8tLF0wvlXcTbiXy6ryz2yLneUfsD5jVs7rCc16iZvfnxfvYeAf4c7TsDbt2F23aC0JytRiAAQWd0itwGZagzU80T348qMaBwVpQoA2kwBuPX3aP4yzA5WRUn_m3jon-mUv-HT6T1yNxFL-qH3hPtkz7cPyNFFr0y9OqbD7UWr-TE9ohdbzerVQ_LzG3g8oBhN1_aXHR23FMghxaMBv30MU8yiJGcLLbgcdNThMtFeLTG7fh7fSUkidBpozKb2zk9gWop3WaDDFAaEpsl4vuzGztOmdXR48vkRGZ1-Gn48y1J9hsxyIReZqIVRQQTPnLGhYio3tuTcFSI01kifi6aG5SuUSuYGmJUPjDmmhAyFkQHWlsdkv522_imhUlScc6uktYYbVioPtBLIIXiRcyJ3A1KsLaFtEi_HGhoTDZsYtJ6O1tNoPZ2sNyCvN-_MeumOf_Y-QQNveqLsdnww7a50imKd13Vhi0YKB9RGsNwAVKCgLOzZgLkqGOTl2j00hCn-99K0HuyksaBJrQBe-IA86d1lM1UpsC5izgak3nGknc-y29KOr6MUuIond9XBf8z7jNzB74sZ54V4TvYX3dK_AEK1MIfxIOIwxsovwKggmA |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Rearing+behaviour+in+the+mouse+behavioural+pattern+monitor+distinguishes+the+effects+of+psychedelics+from+those+of+lisuride+and+TBG&rft.jtitle=Frontiers+in+pharmacology&rft.au=Chen%2C+Yahong&rft.au=Liu%2C+Junhong&rft.au=Yao%2C+Yishan&rft.au=Yan%2C+Haitao&rft.date=2023-02-16&rft.issn=1663-9812&rft.eissn=1663-9812&rft.volume=14&rft.spage=1021729&rft_id=info:doi/10.3389%2Ffphar.2023.1021729&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1663-9812&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1663-9812&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1663-9812&client=summon |