The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect

• Published in: Epigenetics Vol. 11; no. 10; pp. 740 - 749
• Main Authors: Hassan, Hazem E., Keita, Jean-Arnaud, Narayan, Lawrence, Brady, Sean M., Frederick, Richard, Carlson, Samuel, C. Glass, Karen, Natesan, Senthil, Buttolph, Thomm, Fandy, Tamer E.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 02.10.2016
• Subjects: decitabine; Dimethoxycurcumin; DNA methylation; DNA pyrosequencing; histone acetylation; histone methylation; leukemia; Research Paper; histone methylation; leukemia; Dimethoxycurcumin; DNA methylation; DNA pyrosequencing; decitabine; histone acetylation

Curcumin and its analogs exhibited antileukemic activity either as single agent or in combination therapy. Dimethoxycurcumin (DMC) is a more metabolically stable curcumin analog that was shown to induce the expression of promoter-methylated genes without reversing DNA methylation. Accordingly, co-tr...