Cingulum bundle alterations underlie subjective fatigue in multiple sclerosis

• Published in: Multiple sclerosis Vol. 21; no. 4; pp. 442 - 447
• Main Authors: Pardini, Matteo, Bonzano, Laura, Bergamino, Maurizio, Bommarito, Giulia, Feraco, Paola, Murugavel, Abitha, Bove, Marco, Brichetto, Giampaolo, Uccelli, Antonio, Mancardi, Gianluigi, Roccatagliata, Luca
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2015; Sage Publications Ltd
• Subjects: Adult; Diffusion Magnetic Resonance Imaging; Fatigue - etiology; Female; Gyrus Cinguli - pathology; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Multiple Sclerosis, Relapsing-Remitting - complications; Multiple Sclerosis, Relapsing-Remitting - pathology; diffusion tensor imaging; fatigue; cingulum bundle; White matter

Objective: To evaluate the neural basis of subjective fatigue in subjects with multiple sclerosis (MS) using a connectionist framework. Methods: Seventy seven subjects with relapsing–remitting MS were recruited in the study and underwent subjective fatigue evaluations and a diffusion MRI scan. First...