The expression of chemorepulsive guidance receptors and the regenerative abilities of spinal-projecting neurons after spinal cord injury

• Published in: Neuroscience Vol. 341; pp. 95 - 111
• Main Authors: Chen, Jie, Laramore, Cindy, Shifman, Michael I
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 26.01.2017
• Subjects: Animals; axon guidance; Axons - metabolism; Axons - pathology; Blotting, Western; Cell Count; Chemotaxis - physiology; Disease Models, Animal; Down-Regulation; Fish Proteins - antagonists & inhibitors; Fish Proteins - genetics; Fish Proteins - metabolism; identifiable neurons; In Situ Hybridization; In Situ Nick-End Labeling; lamprey; Lampreys; Mauthner cell; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - genetics; Membrane Proteins - metabolism; mRNA expression; Nerve Tissue Proteins - antagonists & inhibitors; Nerve Tissue Proteins - metabolism; Neuroanatomical Tract-Tracing Techniques; Neurology; Oligonucleotides, Antisense; Petromyzontidae; RNA, Messenger - metabolism; Spinal Cord Injuries - metabolism; Spinal Cord Injuries - pathology; spinal cord regeneration; Spinal Cord Regeneration - physiology; spinal cord regeneration; axon guidance; lamprey; identifiable neurons; mRNA expression; Mauthner cell; Mth; RS; TdT; CNS; MOs; ANOVA; SCI; RGM

Highlights • Neogenin is preferentially expressed in the low regeneration capacity neurons. • Downregulation of Neogenin enhances the axonal regeneration after SCI. • Lamprey neurons co-express multiple receptors (Neogenin, UNC5 and PlexinA) • The regeneration depends on co-expression of chemorepuls...