The effects of RNA editing in cancer tissue at different stages in carcinogenesis

RNA editing is one of the most prevalent and abundant forms of post-transcriptional RNA modification observed in normal physiological processes and often aberrant in diseases including cancer. RNA editing changes the sequences of mRNAs, making them different from the source DNA sequence. Edited mRNA...

Full description

Saved in:
Bibliographic Details
Published inRNA biology Vol. 18; no. 11; pp. 1524 - 1539
Main Authors Kurkowiak, Małgorzata, Arcimowicz, Łukasz, Chruściel, Elżbieta, Urban-Wójciuk, Zuzanna, Papak, Ines, Keegan, Liam, O'Connell, Mary, Kowalski, Jacek, Hupp, Ted, Marek-Trzonkowska, Natalia
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 02.11.2021
Subjects
ADARs
Adenosine - genetics
Animals
cancer development
Carcinogenesis - genetics
Carcinogenesis - pathology
Humans
Inosine - genetics
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Review
RNA Editing
RNA editing in cancer
RNA, Double-Stranded - genetics
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
RNA editing
RNA editing in cancer
ADARs
cancer development
Online AccessGet full text

Cover

Abstract RNA editing is one of the most prevalent and abundant forms of post-transcriptional RNA modification observed in normal physiological processes and often aberrant in diseases including cancer. RNA editing changes the sequences of mRNAs, making them different from the source DNA sequence. Edited mRNAs can produce editing-recoded protein isoforms that are functionally different from the corresponding genome-encoded protein isoforms. The major type of RNA editing in mammals occurs by enzymatic deamination of adenosine to inosine (A-to-I) within double-stranded RNAs (dsRNAs) or hairpins in pre-mRNA transcripts. Enzymes that catalyse these processes belong to the adenosine deaminase acting on RNA (ADAR) family. The vast majority of knowledge on the RNA editing landscape relevant to human disease has been acquired using in vitro cancer cell culture models. The limitation of such in vitro models, however, is that the physiological or disease relevance of results obtained is not necessarily obvious. In this review we focus on discussing in vivo occurring RNA editing events that have been identified in human cancer tissue using samples surgically resected or clinically retrieved from patients. We discuss how RNA editing events occurring in tumours in vivo can identify pathological signalling mechanisms relevant to human cancer physiology which is linked to the different stages of cancer progression including initiation, promotion, survival, proliferation, immune escape and metastasis.
AbstractList RNA editing is one of the most prevalent and abundant forms of post-transcriptional RNA modification observed in normal physiological processes and often aberrant in diseases including cancer. RNA editing changes the sequences of mRNAs, making them different from the source DNA sequence. Edited mRNAs can produce editing-recoded protein isoforms that are functionally different from the corresponding genome-encoded protein isoforms. The major type of RNA editing in mammals occurs by enzymatic deamination of adenosine to inosine (A-to-I) within double-stranded RNAs (dsRNAs) or hairpins in pre-mRNA transcripts. Enzymes that catalyse these processes belong to the adenosine deaminase acting on RNA (ADAR) family. The vast majority of knowledge on the RNA editing landscape relevant to human disease has been acquired using in vitro cancer cell culture models. The limitation of such in vitro models, however, is that the physiological or disease relevance of results obtained is not necessarily obvious. In this review we focus on discussing in vivo occurring RNA editing events that have been identified in human cancer tissue using samples surgically resected or clinically retrieved from patients. We discuss how RNA editing events occurring in tumours in vivo can identify pathological signalling mechanisms relevant to human cancer physiology which is linked to the different stages of cancer progression including initiation, promotion, survival, proliferation, immune escape and metastasis.
RNA editing is one of the most prevalent and abundant forms of post-transcriptional RNA modification observed in normal physiological processes and often aberrant in diseases including cancer. RNA editing changes the sequences of mRNAs, making them different from the source DNA sequence. Edited mRNAs can produce editing-recoded protein isoforms that are functionally different from the corresponding genome-encoded protein isoforms. The major type of RNA editing in mammals occurs by enzymatic deamination of adenosine to inosine (A-to-I) within double-stranded RNAs (dsRNAs) or hairpins in pre-mRNA transcripts. Enzymes that catalyse these processes belong to the adenosine deaminase acting on RNA (ADAR) family. The vast majority of knowledge on the RNA editing landscape relevant to human disease has been acquired using cancer cell culture models. The limitation of such models, however, is that the physiological or disease relevance of results obtained is not necessarily obvious. In this review we focus on discussing occurring RNA editing events that have been identified in human cancer tissue using samples surgically resected or clinically retrieved from patients. We discuss how RNA editing events occurring in tumours can identify pathological signalling mechanisms relevant to human cancer physiology which is linked to the different stages of cancer progression including initiation, promotion, survival, proliferation, immune escape and metastasis.
RNA editing is one of the most prevalent and abundant forms of post-transcriptional RNA modification observed in normal physiological processes and often aberrant in diseases including cancer. RNA editing changes the sequences of mRNAs, making them different from the source DNA sequence. Edited mRNAs can produce editing-recoded protein isoforms that are functionally different from the corresponding genome-encoded protein isoforms. The major type of RNA editing in mammals occurs by enzymatic deamination of adenosine to inosine (A-to-I) within double-stranded RNAs (dsRNAs) or hairpins in pre-mRNA transcripts. Enzymes that catalyse these processes belong to the adenosine deaminase acting on RNA (ADAR) family. The vast majority of knowledge on the RNA editing landscape relevant to human disease has been acquired using in vitro cancer cell culture models. The limitation of such in vitro models, however, is that the physiological or disease relevance of results obtained is not necessarily obvious. In this review we focus on discussing in vivo occurring RNA editing events that have been identified in human cancer tissue using samples surgically resected or clinically retrieved from patients. We discuss how RNA editing events occurring in tumours in vivo can identify pathological signalling mechanisms relevant to human cancer physiology which is linked to the different stages of cancer progression including initiation, promotion, survival, proliferation, immune escape and metastasis.
Author O'Connell, Mary
Keegan, Liam
Papak, Ines
Chruściel, Elżbieta
Kurkowiak, Małgorzata
Marek-Trzonkowska, Natalia
Urban-Wójciuk, Zuzanna
Arcimowicz, Łukasz
Kowalski, Jacek
Hupp, Ted
Author_xml – sequence: 1
  givenname: Małgorzata
  orcidid: 0000-0002-4968-7136
  surname: Kurkowiak
  fullname: Kurkowiak, Małgorzata
  email: malgorzata.kurkowiak@ug.edu.pl
  organization: International Centre for Cancer Vaccine Science (ICCVS), University of Gdańsk
– sequence: 2
  givenname: Łukasz
  orcidid: 0000-0003-2073-619X
  surname: Arcimowicz
  fullname: Arcimowicz, Łukasz
  organization: International Centre for Cancer Vaccine Science (ICCVS), University of Gdańsk
– sequence: 3
  givenname: Elżbieta
  orcidid: 0000-0001-9621-2013
  surname: Chruściel
  fullname: Chruściel, Elżbieta
  organization: International Centre for Cancer Vaccine Science (ICCVS), University of Gdańsk
– sequence: 4
  givenname: Zuzanna
  orcidid: 0000-0002-5868-1991
  surname: Urban-Wójciuk
  fullname: Urban-Wójciuk, Zuzanna
  organization: International Centre for Cancer Vaccine Science (ICCVS), University of Gdańsk
– sequence: 5
  givenname: Ines
  orcidid: 0000-0002-0174-8526
  surname: Papak
  fullname: Papak, Ines
  organization: International Centre for Cancer Vaccine Science (ICCVS), University of Gdańsk
– sequence: 6
  givenname: Liam
  orcidid: 0000-0001-7915-5790
  surname: Keegan
  fullname: Keegan, Liam
  organization: CEITEC Masaryk University
– sequence: 7
  givenname: Mary
  orcidid: 0000-0003-3844-6174
  surname: O'Connell
  fullname: O'Connell, Mary
  organization: CEITEC Masaryk University
– sequence: 8
  givenname: Jacek
  orcidid: 0000-0003-0086-0265
  surname: Kowalski
  fullname: Kowalski, Jacek
  organization: Medical University of Gdańsk
– sequence: 9
  givenname: Ted
  orcidid: 0000-0003-0391-0352
  surname: Hupp
  fullname: Hupp, Ted
  organization: University of Edinburgh, Edinburgh Cancer Research Centre
– sequence: 10
  givenname: Natalia
  orcidid: 0000-0003-1201-295X
  surname: Marek-Trzonkowska
  fullname: Marek-Trzonkowska, Natalia
  email: natalia.marek-trzonkowska@ug.edu.pl
  organization: Medical University of Gdańsk
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33593231$$D View this record in MEDLINE/PubMed
BookMark eNp9kNtKAzEURYNU7EU_QckPTM11JvMiFvEGRVHqc8hkMtNIm5RkqvTvTekFffEpgbP2Pskagp7zzgBwidEYI4GuMWdFTkQ-JojgMRZFgQg7AQPMOc8EF6y3vbMi20J9MIzxEyGai5KfgT6lvKSE4gF4m80NNE1jdBehb-D7ywSa2nbWtdA6qJXTJsDOxrg2UHWwtokNxnUwdqo1cQcFbZ1vjTPRxnNw2qhFNBf7cwQ-Hu5nd0_Z9PXx-W4yzTTLRZfxnCFSsYJiRYUpBBGEVrTOS8waQnhdUWYE5hqjktVphpAWiHGeAumHGtMRuNn1rtbV0tQ6vSmohVwFu1RhI72y8u_E2bls_ZdMckhZklTAdwU6-BiDaY5ZjOTWsTw4llvHcu845a5-Lz6mDlITcLsDrGt8WKpvHxa17NRm4UMTklEbJf1_xw-wfIxx
CitedBy_id crossref_primary_10_1038_s41392_022_01270_x
crossref_primary_10_1186_s12864_022_08360_8
crossref_primary_10_1186_s13578_024_01216_6
crossref_primary_10_1038_s41421_022_00460_9
crossref_primary_10_1002_mc_23490
crossref_primary_10_1186_s13059_023_03115_4
crossref_primary_10_3390_cells11071231
crossref_primary_10_3389_fimmu_2022_793234
crossref_primary_10_3390_ijms231911830
crossref_primary_10_1038_s41467_024_48436_5
crossref_primary_10_1186_s12885_022_09773_0
crossref_primary_10_1016_j_pbiomolbio_2022_01_001
crossref_primary_10_3390_ijms25137424
crossref_primary_10_1152_ajpcell_00191_2022
crossref_primary_10_3390_ijms24119305
Cites_doi 10.1128/JVI.01311-08
10.1016/j.ccell.2015.08.013
10.1158/0008-5472.CAN-13-2545
10.1093/oxfordjournals.hmg.a018921
10.1038/s41598-017-10151-1
10.4161/rna.23343
10.1002/bies.201600187
10.1007/978-3-642-32864-0
10.1136/gutjnl-2012-304037
10.1073/pnas.1507882112
10.1093/nar/gkn479
10.1074/jbc.R700002200
10.1038/nsmb.1864
10.1016/j.stem.2016.05.004
10.1038/onc.2015.469
10.1038/ncomms5726
10.1158/0008-5472.CAN-06-3575
10.1016/j.drup.2017.09.001
10.1038/s41467-020-16802-8
10.1093/nar/gkt996
10.1093/nar/gky1163
10.1016/0092-8674(93)90622-W
10.1091/mbc.e02-03-0161
10.1101/gr.2855504
10.1172/jci.insight.99976
10.1038/ng.3279
10.1016/j.celrep.2015.09.032
10.3390/ijms141122796
10.1017/S135583820101007X
10.1038/ncb3110
10.1038/s41586-018-0768-9
10.15252/embr.201439636
10.1038/nchembio.434
10.1038/s41467-018-02851-7
10.1093/nar/gkw767
10.1101/gr.6493107
10.1038/s41467-018-06405-9
10.1146/annurev-biochem-060208-105251
10.1016/0092-8674(95)90328-3
10.1128/MCB.13.6.3350
10.1038/ncomms10715
10.1016/j.celrep.2018.03.118
10.1016/j.celrep.2014.10.041
10.1126/science.3659919
10.1182/blood-2018-02-832576
10.1016/j.celrep.2015.08.080
10.1007/s11010-006-9332-2
10.1261/rna.923308
10.1038/nsmb825
10.1186/1750-1326-5-1
10.1038/ng.2702
10.1186/s13059-014-0575-z
10.1371/journal.pbio.0020391
10.1016/j.tig.2015.10.005
10.1016/j.semcdb.2017.11.018
10.1128/MCB.01519-08
10.1038/s41586-020-2844-1
10.1159/000337106
10.1074/jbc.M117.779868
10.1093/nar/gkx1257
10.1186/gb-2007-8-2-r29
10.1038/s41388-020-1248-x
10.1093/emboj/20.15.4243
10.1038/ng.3378
10.1038/ng.2414
10.1016/j.exphem.2016.06.250
10.1523/JNEUROSCI.2180-07.2007
10.1158/0008-5472.CAN-17-0520
10.1016/j.jhep.2020.07.021
10.1038/s41576-018-0006-1
10.1074/jbc.271.50.31795
10.1146/annurev.nutr.20.1.169
10.1007/s00439-017-1837-0
10.1016/0092-8674(87)90510-1
10.1101/gr.164749.113
10.1172/JCI62925
10.1080/15476286.2016.1203501
10.1128/MCB.15.3.1389
10.1038/s41467-018-07824-4
10.1126/science.1086763
10.1016/j.cell.2018.03.006
10.3389/fmicb.2014.00534
10.1038/ng0693-124
10.1126/science.1138050
10.1186/s40659-018-0185-4
10.1093/nar/gkx1030
10.1038/onc.2012.125
10.1093/bioinformatics/bti411
10.1073/pnas.1703178114
10.1038/s41591-018-0302-5
10.1038/ni.1680
10.1074/jbc.M110.130096
10.1146/annurev-immunol-042718-041257
10.1073/pnas.96.8.4621
10.1038/nm746
10.1038/ncomms3273
10.1084/jem.20132209
10.1038/35017558
10.1073/pnas.251531398
10.1038/emboj.2009.244
10.1086/337952
10.1093/nar/26.24.5699
10.1002/ijc.25022
10.1016/j.str.2005.11.013
10.1007/978-1-0716-0787-9_5
10.1074/jbc.M117.775684
10.1186/s13059-019-1873-2
10.1038/ncomms1324
10.1038/nm.3043
10.1016/j.canlet.2014.12.006
10.1089/107999002760274917
10.1038/srep23226
10.1016/j.ajpath.2015.08.002
10.1080/15476286.2016.1184387
10.18632/oncotarget.17034
10.1038/nature11881
10.1128/MCB.20.6.1982-1992.2000
10.1002/wrna.1226
10.1016/j.jmb.2009.06.009
10.1074/jbc.M311347200
10.1186/s13059-019-1651-1
10.1091/mbc.12.7.1911
10.1016/0092-8674(91)90568-J
10.1093/nar/gkl793
10.1017/S1355838200000170
10.1006/jmbi.1999.2914
10.1101/gr.219741.116
10.1242/jcs.00371
10.1158/2159-8290.CD-15-0344
10.1038/nsmb936
10.1073/pnas.240464097
10.1101/gad.11.3.321
10.1038/s41598-017-02397-6
10.1242/jcs.045112
10.1038/emboj.2008.6
10.1159/000491656
10.1038/nrm.2015.4
10.1093/bioinformatics/btq285
10.1038/s41467-017-01890-w
10.1126/science.1170995
10.1093/nar/24.3.478
10.3892/ijo.2016.3823
10.3390/ijms20225621
10.1038/srep39100
ContentType Journal Article
Copyright 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021
2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021 The Author(s)
Copyright_xml – notice: 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021
– notice: 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2021 The Author(s)
DBID 0YH
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
5PM
DOI 10.1080/15476286.2021.1877024
DatabaseName Taylor & Francis Open Access
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
DatabaseTitleList
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: 0YH
  name: Taylor & Francis Open Access
  url: https://www.tandfonline.com
  sourceTypes: Publisher
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
DocumentTitleAlternate M. KURKOWIAK ET AL
EISSN 1555-8584
EndPage 1539
ExternalDocumentID 10_1080_15476286_2021_1877024
33593231
1877024
Genre Review
Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
0R~
0YH
123
30N
4.4
53G
AAAVI
AAJMT
ABBKH
ABCCY
ABFIM
ABJVF
ABPEM
ABQHQ
ABTAI
ACGFO
ACGFS
ACTIO
ADBBV
ADCVX
AEGYZ
AEISY
AENEX
AEYOC
AFOLD
AHDLD
AIJEM
AIRXU
ALMA_UNASSIGNED_HOLDINGS
ALQZU
AOIJS
AQRUH
AVBZW
BAWUL
BLEHA
C1A
CCCUG
DGEBU
DIK
DKSSO
E3Z
EBS
EMOBN
F5P
FRP
FUNRP
FVPDL
GTTXZ
GX1
HYE
IPNFZ
KYCEM
LJTGL
M4Z
O9-
OK1
P2P
RIG
RPM
SNACF
TEI
TFL
TFT
TFW
TR2
TTHFI
V1K
0VX
AAHBH
ACZPZ
ADOPC
AHDZW
AURDB
BFWEY
BOHLJ
CGR
CUY
CVF
CWRZV
ECM
EIF
EJD
GROUPED_DOAJ
H13
NPM
OVD
PCLFJ
SV3
TDBHL
TEORI
AAYXX
CITATION
5PM
ID FETCH-LOGICAL-c468t-56402b4731a38e782823b3d6914f225db34e815c1094d82300c80455731555c13
IEDL.DBID RPM
ISSN 1547-6286
IngestDate Tue Sep 17 20:36:56 EDT 2024
Fri Dec 06 01:06:38 EST 2024
Sat Sep 28 08:22:29 EDT 2024
Tue Jul 04 18:16:41 EDT 2023
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 11
Keywords RNA editing
RNA editing in cancer
ADARs
cancer development
Language English
License open-access: http://creativecommons.org/licenses/by-nc-nd/4.0/: http://creativecommons.org/licenses/by-nc-nd/4.0/: This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c468t-56402b4731a38e782823b3d6914f225db34e815c1094d82300c80455731555c13
ORCID 0000-0003-0086-0265
0000-0002-5868-1991
0000-0003-3844-6174
0000-0003-1201-295X
0000-0003-2073-619X
0000-0001-7915-5790
0000-0002-0174-8526
0000-0001-9621-2013
0000-0003-0391-0352
0000-0002-4968-7136
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8582992/
PMID 33593231
PageCount 16
ParticipantIDs informaworld_taylorfrancis_310_1080_15476286_2021_1877024
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8582992
pubmed_primary_33593231
crossref_primary_10_1080_15476286_2021_1877024
PublicationCentury 2000
PublicationDate 2021-11-02
PublicationDateYYYYMMDD 2021-11-02
PublicationDate_xml – month: 11
  year: 2021
  text: 2021-11-02
  day: 02
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle RNA biology
PublicationTitleAlternate RNA Biol
PublicationYear 2021
Publisher Taylor & Francis
Publisher_xml – name: Taylor & Francis
References cit0077
cit0078
cit0111
cit0075
Shigeyasu K (cit0117) 2018; 3
cit0076
Sharma S (cit0080) 2019; 20
cit0073
cit0074
cit0071
cit0072
Patnaik SK (cit0070) 2016
Sinigaglia K (cit0024) 1862; 356
Sharma S (cit0068) 2015; 6
cit0119
cit0116
cit0114
cit0115
cit0079
cit0112
cit0113
cit0066
cit0100
cit0064
cit0065
cit0062
cit0063
cit0061
cit0109
cit0107
cit0108
cit0105
cit0106
Lomeli H (cit0034) 1709
cit0103
cit0104
cit0101
cit0069
cit0102
cit0011
cit0099
cit0132
cit0012
cit0133
cit0097
cit0130
cit0010
cit0098
cit0131
cit0095
cit0096
cit0093
cit0094
cit0091
cit0092
cit0090
cit0019
cit0017
cit0138
cit0018
cit0139
cit0015
cit0136
cit0016
cit0137
cit0013
Blow MJ (cit0004) 2006; 7
cit0014
Lee S (cit0036) 2010; 5
cit0135
cit0088
cit0121
cit0001
cit0089
cit0122
cit0086
cit0087
cit0120
cit0084
cit0085
cit0082
cit0083
cit0081
cit0008
cit0009
cit0006
cit0127
cit0007
cit0128
cit0125
cit0005
cit0126
cit0002
cit0123
cit0003
cit0124
cit0033
cit0154
cit0155
cit0031
cit0152
cit0032
cit0153
cit0150
cit0030
cit0151
Eggington JM (cit0060) 2011; 2
Blanc V (cit0067) 2010; 2
Hu X (cit0118) 2017; 39
cit0039
cit0037
cit0038
cit0035
cit0156
cit0022
cit0143
cit0023
cit0020
cit0141
cit0021
Athanasiadis A (cit0048) 2004; 2
cit0142
Chan THM (cit0144) 2016; 151
cit0140
Asaoka M (cit0129) 2019; 20
cit0028
cit0149
cit0029
cit0026
cit0147
cit0027
cit0148
cit0145
cit0025
cit0146
cit0055
cit0056
Chung H (cit0049) 2018; 172
cit0054
cit0051
cit0052
Cappione AJ (cit0110) 1997; 60
cit0050
cit0059
cit0057
cit0058
cit0044
cit0045
cit0042
Amin EM (cit0134) 2017; 10
cit0043
cit0040
cit0041
Lev-Maor G (cit0053) 2007; 8
cit0046
cit0047
References_xml – ident: cit0081
  doi: 10.1128/JVI.01311-08
– ident: cit0091
  doi: 10.1016/j.ccell.2015.08.013
– ident: cit0097
  doi: 10.1158/0008-5472.CAN-13-2545
– ident: cit0090
  doi: 10.1093/oxfordjournals.hmg.a018921
– ident: cit0023
  doi: 10.1038/s41598-017-10151-1
– ident: cit0120
  doi: 10.4161/rna.23343
– year: 1709
  ident: cit0034
  publication-title: Science
  contributor:
    fullname: Lomeli H
– ident: cit0059
  doi: 10.1002/bies.201600187
– volume: 39
  year: 2017
  ident: cit0118
  publication-title: Tumor Biol
  contributor:
    fullname: Hu X
– volume: 60
  start-page: 305
  year: 1997
  ident: cit0110
  publication-title: Am J Hum Genet
  contributor:
    fullname: Cappione AJ
– ident: cit0126
  doi: 10.1007/978-3-642-32864-0
– ident: cit0112
  doi: 10.1136/gutjnl-2012-304037
– volume: 172
  start-page: .e14
  issue: 811
  year: 2018
  ident: cit0049
  publication-title: Cell
  contributor:
    fullname: Chung H
– ident: cit0105
  doi: 10.1073/pnas.1507882112
– ident: cit0063
  doi: 10.1093/nar/gkn479
– ident: cit0050
  doi: 10.1074/jbc.R700002200
– ident: cit0051
  doi: 10.1038/nsmb.1864
– ident: cit0030
  doi: 10.1016/j.stem.2016.05.004
– ident: cit0095
  doi: 10.1038/onc.2015.469
– ident: cit0083
  doi: 10.1038/ncomms5726
– ident: cit0143
  doi: 10.1158/0008-5472.CAN-06-3575
– ident: cit0040
  doi: 10.1016/j.drup.2017.09.001
– ident: cit0085
  doi: 10.1038/s41467-020-16802-8
– ident: cit0087
  doi: 10.1093/nar/gkt996
– ident: cit0046
  doi: 10.1093/nar/gky1163
– ident: cit0031
  doi: 10.1016/0092-8674(93)90622-W
– ident: cit0013
  doi: 10.1091/mbc.e02-03-0161
– ident: cit0047
  doi: 10.1101/gr.2855504
– volume: 3
  year: 2018
  ident: cit0117
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.99976
  contributor:
    fullname: Shigeyasu K
– volume: 2
  start-page: 594
  year: 2010
  ident: cit0067
  publication-title: Rev. Syst. Biol. Med.
  contributor:
    fullname: Blanc V
– volume-title: Proceedings of the RNA 2016, Annual Meeting of RNA Society
  year: 2016
  ident: cit0070
  contributor:
    fullname: Patnaik SK
– ident: cit0146
  doi: 10.1038/ng.3279
– ident: cit0116
  doi: 10.1016/j.celrep.2015.09.032
– ident: cit0042
  doi: 10.3390/ijms141122796
– ident: cit0061
  doi: 10.1017/S135583820101007X
– ident: cit0064
  doi: 10.1038/ncb3110
– ident: cit0151
  doi: 10.1038/s41586-018-0768-9
– ident: cit0125
  doi: 10.15252/embr.201439636
– ident: cit0052
  doi: 10.1038/nchembio.434
– ident: cit0135
  doi: 10.1038/s41467-018-02851-7
– ident: cit0089
  doi: 10.1093/nar/gkw767
– ident: cit0149
  doi: 10.1101/gr.6493107
– ident: cit0128
  doi: 10.1038/s41467-018-06405-9
– ident: cit0006
  doi: 10.1146/annurev-biochem-060208-105251
– ident: cit0066
  doi: 10.1016/0092-8674(95)90328-3
– ident: cit0155
  doi: 10.1128/MCB.13.6.3350
– ident: cit0130
  doi: 10.1038/ncomms10715
– ident: cit0133
  doi: 10.1016/j.celrep.2018.03.118
– ident: cit0008
  doi: 10.1016/j.celrep.2014.10.041
– ident: cit0147
  doi: 10.1126/science.3659919
– ident: cit0096
  doi: 10.1182/blood-2018-02-832576
– volume: 7
  year: 2006
  ident: cit0004
  publication-title: Genome Biol
  contributor:
    fullname: Blow MJ
– ident: cit0094
  doi: 10.1016/j.celrep.2015.08.080
– ident: cit0121
  doi: 10.1007/s11010-006-9332-2
– ident: cit0003
  doi: 10.1261/rna.923308
– ident: cit0039
  doi: 10.1038/nsmb825
– volume: 5
  start-page: 1
  year: 2010
  ident: cit0036
  publication-title: Mol. Neurodegener
  doi: 10.1186/1750-1326-5-1
  contributor:
    fullname: Lee S
– ident: cit0072
  doi: 10.1038/ng.2702
– ident: cit0115
  doi: 10.1186/s13059-014-0575-z
– volume: 2
  year: 2004
  ident: cit0048
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0020391
  contributor:
    fullname: Athanasiadis A
– ident: cit0076
  doi: 10.1016/j.tig.2015.10.005
– ident: cit0100
  doi: 10.1016/j.semcdb.2017.11.018
– ident: cit0012
  doi: 10.1128/MCB.01519-08
– ident: cit0153
  doi: 10.1038/s41586-020-2844-1
– ident: cit0138
  doi: 10.1159/000337106
– ident: cit0010
  doi: 10.1074/jbc.M117.779868
– ident: cit0137
  doi: 10.1093/nar/gkx1257
– volume: 8
  year: 2007
  ident: cit0053
  publication-title: Genome Biol
  doi: 10.1186/gb-2007-8-2-r29
  contributor:
    fullname: Lev-Maor G
– ident: cit0140
  doi: 10.1038/s41388-020-1248-x
– ident: cit0057
  doi: 10.1093/emboj/20.15.4243
– ident: cit0074
  doi: 10.1038/ng.3378
– ident: cit0027
  doi: 10.1038/ng.2414
– ident: cit0029
  doi: 10.1016/j.exphem.2016.06.250
– ident: cit0103
  doi: 10.1523/JNEUROSCI.2180-07.2007
– ident: cit0093
  doi: 10.1158/0008-5472.CAN-17-0520
– ident: cit0145
  doi: 10.1016/j.jhep.2020.07.021
– ident: cit0035
  doi: 10.1038/s41576-018-0006-1
– ident: cit0044
  doi: 10.1074/jbc.271.50.31795
– ident: cit0077
  doi: 10.1146/annurev.nutr.20.1.169
– ident: cit0002
  doi: 10.1007/s00439-017-1837-0
– ident: cit0148
  doi: 10.1016/0092-8674(87)90510-1
– ident: cit0007
  doi: 10.1101/gr.164749.113
– ident: cit0136
  doi: 10.1172/JCI62925
– ident: cit0021
  doi: 10.1080/15476286.2016.1203501
– ident: cit0018
  doi: 10.1128/MCB.15.3.1389
– ident: cit0026
  doi: 10.1038/s41467-018-07824-4
– ident: cit0038
  doi: 10.1126/science.1086763
– ident: cit0062
  doi: 10.1016/j.cell.2018.03.006
– ident: cit0071
  doi: 10.3389/fmicb.2014.00534
– ident: cit0154
  doi: 10.1038/ng0693-124
– ident: cit0065
  doi: 10.1126/science.1138050
– ident: cit0141
  doi: 10.1186/s40659-018-0185-4
– ident: cit0001
  doi: 10.1093/nar/gkx1030
– ident: cit0104
  doi: 10.1038/onc.2012.125
– ident: cit0123
  doi: 10.1093/bioinformatics/bti411
– ident: cit0132
  doi: 10.1073/pnas.1703178114
– ident: cit0152
  doi: 10.1038/s41591-018-0302-5
– ident: cit0025
  doi: 10.1038/ni.1680
– ident: cit0037
  doi: 10.1074/jbc.M110.130096
– ident: cit0028
  doi: 10.1146/annurev-immunol-042718-041257
– ident: cit0017
  doi: 10.1073/pnas.96.8.4621
– ident: cit0101
  doi: 10.1038/nm746
– ident: cit0055
  doi: 10.1038/ncomms3273
– ident: cit0113
  doi: 10.1084/jem.20132209
– ident: cit0032
  doi: 10.1038/35017558
– volume: 356
  year: 1862
  ident: cit0024
  publication-title: Biochim Biophys Acta - Genet Regul Mech
  contributor:
    fullname: Sinigaglia K
– ident: cit0102
  doi: 10.1073/pnas.251531398
– ident: cit0009
  doi: 10.1038/emboj.2009.244
– ident: cit0109
  doi: 10.1086/337952
– volume: 10
  year: 2017
  ident: cit0134
  publication-title: Sci Signal
  contributor:
    fullname: Amin EM
– ident: cit0054
  doi: 10.1093/nar/26.24.5699
– ident: cit0099
  doi: 10.1002/ijc.25022
– ident: cit0041
  doi: 10.1016/j.str.2005.11.013
– ident: cit0084
  doi: 10.1007/978-1-0716-0787-9_5
– ident: cit0131
  doi: 10.1074/jbc.M117.775684
– ident: cit0022
  doi: 10.1186/s13059-019-1873-2
– volume: 2
  start-page: 1
  year: 2011
  ident: cit0060
  publication-title: Nat Commun
  doi: 10.1038/ncomms1324
  contributor:
    fullname: Eggington JM
– ident: cit0005
  doi: 10.1126/science.1138050
– ident: cit0107
  doi: 10.1038/nm.3043
– ident: cit0122
  doi: 10.1016/j.canlet.2014.12.006
– ident: cit0043
  doi: 10.1089/107999002760274917
– ident: cit0092
  doi: 10.1038/srep23226
– ident: cit0020
  doi: 10.1016/j.ajpath.2015.08.002
– ident: cit0079
  doi: 10.1080/15476286.2016.1184387
– ident: cit0098
  doi: 10.18632/oncotarget.17034
– ident: cit0075
  doi: 10.1038/nature11881
– ident: cit0108
  doi: 10.1128/MCB.20.6.1982-1992.2000
– volume: 6
  start-page: 1
  year: 2015
  ident: cit0068
  publication-title: Nat Commun
  contributor:
    fullname: Sharma S
– ident: cit0078
  doi: 10.1002/wrna.1226
– ident: cit0127
  doi: 10.1016/j.jmb.2009.06.009
– ident: cit0019
  doi: 10.1074/jbc.M311347200
– volume: 20
  start-page: 1
  year: 2019
  ident: cit0080
  publication-title: Genome Biol
  doi: 10.1186/s13059-019-1651-1
  contributor:
    fullname: Sharma S
– ident: cit0016
  doi: 10.1091/mbc.12.7.1911
– ident: cit0033
  doi: 10.1016/0092-8674(91)90568-J
– ident: cit0088
  doi: 10.1093/nar/gkl793
– volume: 151
  start-page: e10
  issue: 637
  year: 2016
  ident: cit0144
  publication-title: Gastroenterology
  contributor:
    fullname: Chan THM
– ident: cit0011
  doi: 10.1017/S1355838200000170
– ident: cit0058
  doi: 10.1006/jmbi.1999.2914
– ident: cit0139
  doi: 10.1101/gr.219741.116
– ident: cit0015
  doi: 10.1242/jcs.00371
– ident: cit0073
  doi: 10.1158/2159-8290.CD-15-0344
– ident: cit0056
  doi: 10.1038/nsmb936
– ident: cit0045
  doi: 10.1073/pnas.240464097
– ident: cit0106
  doi: 10.1101/gad.11.3.321
– ident: cit0150
  doi: 10.1038/s41598-017-02397-6
– ident: cit0142
  doi: 10.1242/jcs.045112
– ident: cit0124
  doi: 10.1038/emboj.2008.6
– ident: cit0156
  doi: 10.1159/000491656
– ident: cit0014
  doi: 10.1038/nrm.2015.4
– ident: cit0086
  doi: 10.1093/bioinformatics/btq285
– ident: cit0119
  doi: 10.1038/s41467-017-01890-w
– ident: cit0082
  doi: 10.1126/science.1170995
– ident: cit0111
  doi: 10.1093/nar/24.3.478
– ident: cit0114
  doi: 10.3892/ijo.2016.3823
– volume: 20
  year: 2019
  ident: cit0129
  publication-title: Int J Mol Sci
  doi: 10.3390/ijms20225621
  contributor:
    fullname: Asaoka M
– ident: cit0069
  doi: 10.1038/srep39100
SSID ssj0036895
Score 2.4398348
SecondaryResourceType review_article
Snippet RNA editing is one of the most prevalent and abundant forms of post-transcriptional RNA modification observed in normal physiological processes and often...
SourceID pubmedcentral
crossref
pubmed
informaworld
SourceType Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 1524
SubjectTerms ADARs
Adenosine - genetics
Animals
cancer development
Carcinogenesis - genetics
Carcinogenesis - pathology
Humans
Inosine - genetics
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Review
RNA Editing
RNA editing in cancer
RNA, Double-Stranded - genetics
RNA-Binding Proteins - genetics
RNA-Binding Proteins - metabolism
SummonAdditionalLinks – databaseName: Taylor & Francis Open Access
  dbid: 0YH
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV07T8MwELagLCwIKI_ykgfE5hLHduKOFaKqkKgEohJMUezYJQMpasLAv-fsJFUzIAbGJL7EurP9feec7xC6BspuuVWGwESLCWcmJRJgh6TUWs7DVIV-w-1xFk3n_OFVtNGEZRNW6XxoWyeK8Gu1m9ypKtuIuFtA_didqATvLqRDKuMYgGYb7bhU5a6IQfA2bRdjFklfeMWJECfTHuL57TUdeOokL92AqG745AYeTfbRXkMk8bi2_AHaMsUh6o8LcKI_vvEN9qGdfs-8j55gMOAmcgMvLX6ejTGAlot4xnmBtbP8ClfeBjitcFs1pcLAHRemrButdF4sF25tzMsjNJ_cv9xNSVNLgWgeyYqICBxFxWNGUyYN0AIZMsWyaES5hSmdKcaNpEJTcPcy9_Mt0BLYngABIeA2O0a9YlmYU4S1ZlJyw4AsAP1QXIU8DTQLwM2mmRZqgIatCpPPOmVGQptMpK3OE6fzpNH5AI02FZ1Ufq_C1oVFEvaH7EltjPWnGBPASRkdoLhjpnUDl1C7-6TI331ibSkkoHN49o_-nKNdd-lPK4YXqFetvswl0JZKXfmB-QNHXOBL
  priority: 102
  providerName: Taylor & Francis
Title The effects of RNA editing in cancer tissue at different stages in carcinogenesis
URI https://www.tandfonline.com/doi/abs/10.1080/15476286.2021.1877024
https://www.ncbi.nlm.nih.gov/pubmed/33593231
https://pubmed.ncbi.nlm.nih.gov/PMC8582992
Volume 18
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwED-cgvgifjs_Rh7Et25Nk7TxcahjCIqK4vSlNFk6C64bsz7433tJW1mfBF_Thoa7S-536e_uAM4Qsqc8VcbDjRZ5nJnEk-h2vISmKedBogJ34XZ7Fw6f-c1IjFZA1LkwjrSvVdbNP6bdPHt33Mr5VPdqnljv_vZSComnaNBrQQvdbx2il8cvC6VrtYLQIPJs3mWdtiP9nh2zQxgWBrRLZRShh9qAdcYEwhhGG76pUbl0yT81uZNLzmiwBZsViiT9crXbsGLyHdjt5xhBT7_JOXG8TndhvgsPaAmkom2QWUoe7_oEPZalO5MsJ9qqfUEKpwCSFKRumVIQBI4T81m-tNBZPpvYgzH73IPnwfXT5dCrGil4moey8ESIUaLiEaMJkwYxgQyYYuPwgvIU9_NYMW4kFZpirDe2f958LRHqCZwgBA6zfVjNZ7k5BKI1k5IbhkgBsYfiKuCJr5mPMTYda6Ha0K1FGM_LehkxrcqQ1uKPrfjjSvxtuFgWdFy4i4q07CoSsz_mHpTK-P1Urck2RA01_b5gq2k3n6CRuaralVEd_XvmMWzYxblExeAEVovFlzlFxFKoDrT812EH1vrDq7eXjrPXH0vI5ok
link.rule.ids 230,314,727,780,784,885,27502,27924,27925,53791,53793,59143,59144,59886,60675
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT8MwDLZgHODC-zGeOSBuHUuTtNlxQqABYxJok7hVTZaOCdGhrTvAr8dJW7QiIQ5cm7ptYsf-7Do2wDlC9oQnyni40UKPMxN7Es2OF9Mk4dyPle8Cbg-9oDPgd8_ieeEsjE2rtD50kheKcLrabm4bjC5T4i7R7If2SCW6dz5tUBmGaGmWYUW0pLRSzpq9UhuzQLrOK5bEszTlKZ7fHlOxT5XqpQs2qpo_uWCQbjZAl1PJ81BeG_NMNfTnjyqP_5vrJqwXeJW0cwHbgiWTbsNOO0Vf_e2DXBCXQepC8zvwiDJHigQRMknIU69N0DbaxGoyTom2AjYlmWM1iTNSNmfJCELUkZnlN031OJ2MrAoez3ZhcHPdv-p4RcsGT_NAZp4I0B9VPGQ0ZtIg-pA-U2wYtChPUHMMFeNGUqEpepVD-4-vqSWCSoEEQuBltge1dJKaAyBaMym5YYhJEOUornweNzVrojdPh1qoOjRKRkXveWWOiBYFT8tFi-yiRcWi1aG1yM4ocyGRJO9fErE_aPdzln-_ijGB0JfROoQVYfi-wdbtro6k4xdXv1sKiSDAP_zH95zBaqf_0I26t737I1izQ-6ApH8MtWw6NyeIlDJ16rbCF11SA98
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT-MwEB5BkRAXdnmXZcEHxC2lju3EPVbLVjwrQCBxi2LHLhUiRW04wK_fsZOgBmnFgWucSWLPeOYbZx4AhwjZLbfKBLjR4oAzkwYSzU6QUms5D1MV-gO3q2F0es_PH0QdTTirwiqdD23LQhFeV7vN_ZLZOiLuGK1-7DIq0bsLaYfKOEZDswhLkUO_LoujO6yVMYukb7ziSAJHUyfx_O8xDfPUKF46Z6Ka4ZNz9mjwA1Q9kzIM5anzWqiOfv9U5PFbU_0JqxVaJf1SvNZgweTrsNHP0VN_fiNHxMeP-oP5DbhBiSNVeAiZWHI77BO0jC6smoxzop14TUnhGU3SgtStWQqCAHVkZuVNUz3OJyOngMezTbgf_L37cxpUDRsCzSNZBCJCb1TxmNGUSYPYQ4ZMsSzqUW5Rb2SKcSOp0BR9ysz94etqiZBSIIEQeJltQSuf5GYHiNZMSm4YIhLEOIqrkKddzbroy9NMC9WGTs2n5KWsy5HQqtxpvWiJW7SkWrQ29Oa5mRT-QMSW3UsS9gXtdsnxj1cxJhD4MtqGuCELHze4qt3NkXz86Kt3SyERAoS73_ieA1i-Phkkl2fDi1-w4kZ8dmS4B61i-mp-I0wq1L7fCP8AHS0Cgw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effects+of+RNA+editing+in+cancer+tissue+at+different+stages+in+carcinogenesis&rft.jtitle=RNA+biology&rft.au=Kurkowiak%2C+Ma%C5%82gorzata&rft.au=Arcimowicz%2C+%C5%81ukasz&rft.au=Chru%C5%9Bciel%2C+El%C5%BCbieta&rft.au=Urban-W%C3%B3jciuk%2C+Zuzanna&rft.date=2021-11-02&rft.eissn=1555-8584&rft.volume=18&rft.issue=11&rft.spage=1524&rft_id=info:doi/10.1080%2F15476286.2021.1877024&rft_id=info%3Apmid%2F33593231&rft.externalDocID=33593231
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1547-6286&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1547-6286&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1547-6286&client=summon