Randomized Phase II Trials: A Long-term Investment With Promising Returns - Sharma, Manish R.; Stadler, Walter M.; Ratain, Mark J. (JNCI : Journal of the National Cancer Institute, 2011)
Keywords: Antineoplastic Agents - therapeutic use; Biological and medical sciences; Chemotherapy, Adjuvant; Clinical trials; Clinical Trials, Phase II as Topic - methods; Clinical Trials, Phase II as Topic - standards; Clinical Trials, Phase III as Topic; Confounding Factors (Epidemiology); Drugs; Endpoint Determination; Evidence-Based Medicine; Health Resources - utilization; Humans; Life Expectancy; Medical sciences; Molecular Targeted Therapy - methods; Molecular Targeted Therapy - standards; Molecular Targeted Therapy - trends; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Oncology; Patient Selection; Patients; R&D; Randomized Controlled Trials as Topic - methods; Randomized Controlled Trials as Topic - statistics & numerical data; Reproducibility of Results; Research & development; Research Design - standards; Research Design - trends; Review; Sample Size; Selection Bias; Time Factors; Treatment Failure; Tumors; Antineoplastic agent; Human; Randomization; Cancerology; Treatment; Phase II trial; Malignant tumor; Long term; Cancer