Biodistribution and dosimetry in humans of two inverse agonists to image cannabinoid CB1 receptors using positron emission tomography

• Published in: European journal of nuclear medicine and molecular imaging Vol. 37; no. 8; pp. 1499 - 1506
• Main Authors: Terry, Garth E., Hirvonen, Jussi, Liow, Jeih-San, Seneca, Nicholas, Tauscher, Johannes T., Schaus, John M., Phebus, Lee, Felder, Christian C., Morse, Cheryl L., Pike, Victor W., Halldin, Christer, Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.08.2010; Springer Nature B.V
• Subjects: Adult; Binding sites; Biomarkers; Brain - diagnostic imaging; Brain - metabolism; Cardiology; Drug Inverse Agonism; Female; Humans; Imaging; Male; Medicine; Medicine & Public Health; Neurology; Nuclear Medicine; Oncology; Original Article; Orthopedics; Pharmacology; Positron-Emission Tomography - methods; Pyrrolidinones - pharmacokinetics; Pyrrolidinones - pharmacology; Radiology; Radiometry; Receptor, Cannabinoid, CB1 - metabolism; Tomography; F-FMPEP; Dosimetry; C-MePPEP; PET
• ISSN: 1619-7070; 1619-7089; 1619-7089
• DOI: 10.1007/s00259-010-1411-7

Purpose Cannabinoid subtype 1 (CB 1 ) receptors are found in nearly every organ in the body, may be involved in several neuropsychiatric and metabolic disorders, and are therefore an active target for pharmacotherapy and biomarker development. We recently reported brain imaging of CB 1 receptors wit...