Bone marrow adipocytes

Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow. Little functional significance has been attributed to these cells, a paradigm that still pe...

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Published inAdipocyte Vol. 6; no. 3; pp. 193 - 204
Main Authors Horowitz, Mark C., Berry, Ryan, Holtrup, Brandon, Sebo, Zachary, Nelson, Tracy, Fretz, Jackie A., Lindskog, Dieter, Kaplan, Jennifer L., Ables, Gene, Rodeheffer, Matthew S., Rosen, Clifford J.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 03.07.2017
Subjects
adipocyte progenitors
Adipocytes - metabolism
Adipocytes - physiology
Adipocytes, Brown - metabolism
Adipocytes, White - metabolism
Adipogenesis - physiology
Adipokines - physiology
Adipose Tissue - physiology
Adipose Tissue, Brown - metabolism
Adipose Tissue, White - metabolism
Animals
Bone Marrow - metabolism
Bone Marrow - physiology
Bone Marrow Cells - cytology
Bone Marrow Cells - physiology
Cell Differentiation - physiology
Humans
lineage tracing
marrow adipocyte differentiation
marrow adipose tissue
marrow fat
Mice
Reviews
Thermogenesis
marrow adipose tissue
adipocyte progenitors
marrow adipocyte differentiation
marrow fat
lineage tracing
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Abstract Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow. Little functional significance has been attributed to these cells, a paradigm that still persists today. However, we now know that marrow adipose tissue increases with age and in response to a variety of physiologic induction signals. Bone marrow adipocytes have recently been shown to influence other cell populations within the marrow and can affect whole body metabolism by the secretion of a defined set of adipokines. Recent research shows that marrow adipocytes are distinct from white, brown and beige adipocytes, indicating that the bone marrow is a distinct adipose depot. This review will highlight recent data regarding these areas and the interactions of marrow adipose tissue (MAT) with cells within and outside of the bone marrow.
AbstractList Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or interactions with other cells in the bone marrow. Little functional significance has been attributed to these cells, a paradigm that still persists today. However, we now know that marrow adipose tissue increases with age and in response to a variety of physiologic induction signals. Bone marrow adipocytes have recently been shown to influence other cell populations within the marrow and can affect whole body metabolism by the secretion of a defined set of adipokines. Recent research shows that marrow adipocytes are distinct from white, brown and beige adipocytes, indicating that the bone marrow is a distinct adipose depot. This review will highlight recent data regarding these areas and the interactions of marrow adipose tissue (MAT) with cells within and outside of the bone marrow.
Author Sebo, Zachary
Lindskog, Dieter
Nelson, Tracy
Fretz, Jackie A.
Rodeheffer, Matthew S.
Holtrup, Brandon
Ables, Gene
Rosen, Clifford J.
Berry, Ryan
Kaplan, Jennifer L.
Horowitz, Mark C.
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  givenname: Ryan
  surname: Berry
  fullname: Berry, Ryan
  organization: Department of Orthopaedics and Rehabilitation, Yale University School of Medicine
– sequence: 3
  givenname: Brandon
  surname: Holtrup
  fullname: Holtrup, Brandon
  organization: Department of Molecular, Cell, and Developmental Biology, Yale University
– sequence: 4
  givenname: Zachary
  surname: Sebo
  fullname: Sebo, Zachary
  organization: Department of Molecular, Cell, and Developmental Biology, Yale University
– sequence: 5
  givenname: Tracy
  surname: Nelson
  fullname: Nelson, Tracy
  organization: Department of Orthopaedics and Rehabilitation, Yale University School of Medicine
– sequence: 6
  givenname: Jackie A.
  surname: Fretz
  fullname: Fretz, Jackie A.
  organization: Department of Orthopaedics and Rehabilitation, Yale University School of Medicine
– sequence: 7
  givenname: Dieter
  surname: Lindskog
  fullname: Lindskog, Dieter
  organization: Department of Orthopaedics and Rehabilitation, Yale University School of Medicine
– sequence: 8
  givenname: Jennifer L.
  surname: Kaplan
  fullname: Kaplan, Jennifer L.
  organization: Department of Comparative Medicine and Molecular, Cellular, and Developmental Biology, Yale University School of Medicine
– sequence: 9
  givenname: Gene
  surname: Ables
  fullname: Ables, Gene
  organization: Orentreich Foundation for the Advancement of Science
– sequence: 10
  givenname: Matthew S.
  surname: Rodeheffer
  fullname: Rodeheffer, Matthew S.
  organization: Department of Comparative Medicine and Molecular, Cellular, and Developmental Biology, Yale University School of Medicine
– sequence: 11
  givenname: Clifford J.
  surname: Rosen
  fullname: Rosen, Clifford J.
  organization: The Center for Clinical and Translational Research, Maine Medical Center Research Institute
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adipocyte progenitors
marrow adipocyte differentiation
marrow fat
lineage tracing
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Snippet Adipocytes were identified in human bone marrow more than a century ago, yet until recently little has been known about their origin, development, function or...
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SubjectTerms adipocyte progenitors
Adipocytes - metabolism
Adipocytes - physiology
Adipocytes, Brown - metabolism
Adipocytes, White - metabolism
Adipogenesis - physiology
Adipokines - physiology
Adipose Tissue - physiology
Adipose Tissue, Brown - metabolism
Adipose Tissue, White - metabolism
Animals
Bone Marrow - metabolism
Bone Marrow - physiology
Bone Marrow Cells - cytology
Bone Marrow Cells - physiology
Cell Differentiation - physiology
Humans
lineage tracing
marrow adipocyte differentiation
marrow adipose tissue
marrow fat
Mice
Reviews
Thermogenesis
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Title Bone marrow adipocytes
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