Sulforaphane-induced autophagy flux prevents prion protein-mediated neurotoxicity through AMPK pathway
Highlights • Sulforaphane protected neuron cells against PrP (106–126)-mediated neurotoxicity. • The protection effect of sulforaphane is induced through autophagy flux pathway. • The protection effect mediated by autophagy is regulated by AMPK signals.
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Published in | Neuroscience Vol. 278; pp. 31 - 39 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Ltd
10.10.2014
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Sulforaphane protected neuron cells against PrP (106–126)-mediated neurotoxicity. • The protection effect of sulforaphane is induced through autophagy flux pathway. • The protection effect mediated by autophagy is regulated by AMPK signals. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0306-4522 1873-7544 |
DOI: | 10.1016/j.neuroscience.2014.07.072 |