Population pharmacokinetics of prophylactic cefoxitin in patients undergoing colorectal surgery

• Published in: European journal of clinical pharmacology Vol. 68; no. 5; pp. 735 - 745
• Main Authors: Isla, Arantxazu, Trocóniz, Iñaki F., de Tejada, Ignacio López, Vázquez, Silvia, Canut, Andrés, López, Jesús Muriel, Solinís, María Ángeles, Gascón, Alicia Rodríguez
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.05.2012; Springer; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - blood; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - therapeutic use; Antibiotic Prophylaxis; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cefoxitin - blood; Cefoxitin - pharmacokinetics; Cefoxitin - therapeutic use; Colon - surgery; Creatinine - blood; Creatinine - metabolism; Elective Surgical Procedures - adverse effects; Glomerular Filtration Rate; Half-Life; Humans; Male; Medical sciences; Metabolic Clearance Rate; Middle Aged; Models, Biological; Pharmacokinetics and Disposition; Pharmacology. Drug treatments; Pharmacology/Toxicology; Prospective Studies; Rectum - surgery; Surgical Wound Infection - prevention & control; Population pharmacokinetics; Cefoxitin; Surgery; Prophylaxis; Human; Prevention; Cephalosporin derivatives; Antibiotic; β-Lactams; Antibacterial agent

Purpose To elucidate whether a dose of 2 g cefoxitin as a prophylactic agent in patients undergoing elective colorectal surgery is able to maintain free drug concentrations above the minimum inhibitory concentration of the microorganisms involved in surgical site infection. Methods This was a prospe...