Successive epoxy and carbodiimide cross-linking of dermal sheep collagen

• Published in: Biomaterials Vol. 20; no. 10; pp. 921 - 931
• Main Authors: Zeeman, Raymond, Dijkstra, Pieter J., van Wachem, Pauline B., van Luyn, Marja J.A., Hendriks, Marc, Cahalan, Patrick T., Feijen, Jan
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.05.1999; Elsevier Science
• Subjects: Acylation; Amines; Animals; Biocompatible Materials - chemistry; Biodegradation; Biological and medical sciences; Biomechanical Phenomena; Butylene Glycols; Carbodiimide; Collagen; Collagen - chemistry; Collagenases; Cross-linking; Cross-Linking Reagents; Crosslinking; Drug Stability; Enzyme kinetics; Epoxy compounds; Epoxy resins; Ethyldimethylaminopropyl Carbodiimide; In Vitro Techniques; In-vitro degradation; Materials Testing; Mechanical properties; Medical sciences; Polyimides; Pronase; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Sheep; Technology. Biomaterials. Equipments. Material. Instrumentation; Tensile Strength; Mechanical properties; Cross-linking; Collagen; Carbodiimide; In-vitro degradation; Epoxy compounds; Carboid; Epoxy resin; Crosslinking; In vitro; Imide; Vertebrata; Mammalia; Animal; Enzymatic digestion; Sheep; Biomaterial; Artiodactyla; Derm; Ungulata; Physicochemical properties

Cross-linking of dermal sheep collagen (N-DSC, T s=46°C, number of amine groups =31 (n/1000) ) with 1,4-butanediol diglycidyl ether (BDDGE) at pH 9.0 resulted in a material (BD90) with a high T s (69° C) , a decreased number of amine groups of 15 ( n/1000) and a high resistance towards collagenase a...