A polymorphism at the microRNA binding site in the 3' untranslated region of RYR3 is associated with outcome in hepatocellular carcinoma

• Published in: OncoTargets and therapy Vol. 8; pp. 2075 - 2079
• Main Authors: Zhang, Xiaolan, Guo, Zhanjun, Wu, Xiaoyan, Peng, Chenxing
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2015; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Binding sites; Breast cancer; Deoxyribonucleic acid; DNA; DNA-ligand interactions; Gastroenterology; Genes; Genetic aspects; Genomics; Health aspects; Hepatitis; Hepatology; Hepatoma; Identification and classification; Liver cancer; Lung cancer; Medical prognosis; MicroRNAs; Original Research; Polymorphism; Prognosis; Single nucleotide polymorphisms; Survival analysis; United States > US; China; SNP; RYR3; hepatocellular carcinoma; outcome; rs1044129

MicroRNAs can bind to the 3' untranslated regions (UTRs) of messenger RNAs, where they interfere with the translation of targeting genes, thereby regulating cell differentiation, apoptosis, and tumorigenesis. In this study, three microRNA binding site single nucleotide polymorphisms (SNPs) loca...