Morphological Characteristics of the Central Compartment of the Erythron in Aggressive and Indolent Non-Hodgkin’s Lymphomas

• Published in: Bulletin of experimental biology and medicine Vol. 151; no. 2; pp. 259 - 263
• Main Authors: Dolgikh, T. Yu, Domnikova, N. P., Petrusenko, E. E., Mal’tseva, N. A., Kachesov, I. V.
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.06.2011; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomedical and Life Sciences; Biomedicine; Bone Marrow - drug effects; Bone Marrow - pathology; Cancer; Cell Biology; Cell Count; Chemotherapy; Erythroid Cells - drug effects; Erythroid Cells - pathology; Female; Hematopoiesis - drug effects; Humans; Internal Medicine; Laboratory Medicine; Lymphoma, Non-Hodgkin - drug therapy; Lymphoma, Non-Hodgkin - pathology; Male; Middle Aged; Non-Hodgkin's lymphomas; Pathology; Young Adult; aggressive lymphomas; erythron; bone marrow; trepanobiopsy; indolent lymphomas
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-011-1303-2

Structural changes in cells of the central compartment of the erythron depended on tumor infiltration of the bone marrow. Cytostatic therapy was shown to improve quantitative indexes, but had no effect on morphological characteristics of the erythron. Examination of trepanobiopsy specimens from the iliac crest during chemotherapy revealed the existence of specific relationships between the erythron, other cells and tissues of the bone marrow, and tumor. Significant changes in the erythron were found during diffuse tumor infiltration and treatment with anthracycline antibiotics.