Growing E. coli to high cell density—A historical perspective on method development
E. coli is the major bacterial platform for expressing simple heterologous proteins. Growing E. coli to high densities has been the subject of numerous studies since the early 1970s, exploring the limits of bacterial culture density in order to achieve maximum productivity. Research strategies were...
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| Published in | Biotechnology advances Vol. 23; no. 5; pp. 345 - 357 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier Inc
01.07.2005
New York, NY Elsevier |
| Subjects | |
| Online Access | Get full text |
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| Abstract | E. coli is the major bacterial platform for expressing simple heterologous proteins. Growing
E. coli to high densities has been the subject of numerous studies since the early 1970s, exploring the limits of bacterial culture density in order to achieve maximum productivity. Research strategies were focused on improving the cultivation techniques, manipulating the bacteria's physiology or both. As a result, batch, fed batch and dialysis fermentation techniques had been developed. These growth strategies, together with optimization of media composition and the application of molecular biology methods, made it possible to grow
E. coli to cell densities of up to 190 g/l (dry weight), while avoiding media precipitation and preventing acetate accumulation. Additional research on the effects of heterologous protein biosynthesis on signal transduction, proteolysis and post transcription events in
E. coli may improve its productivity. |
|---|---|
| AbstractList | E. coli is the major bacterial platform for expressing simple heterologous proteins. Growing E. coli to high densities has been the subject of numerous studies since the early 1970s, exploring the limits of bacterial culture density in order to achieve maximum productivity. Research strategies were focused on improving the cultivation techniques, manipulating the bacteria's physiology or both. As a result, batch, fed batch and dialysis fermentation techniques had been developed. These growth strategies, together with optimization of media composition and the application of molecular biology methods, made it possible to grow E. coli to cell densities of up to 190 g/l (dry weight), while avoiding media precipitation and preventing acetate accumulation. Additional research on the effects of heterologous protein biosynthesis on signal transduction, proteolysis and post transcription events in E. coli may improve its productivity. E. coli is the major bacterial platform for expressing simple heterologous proteins. Growing E. coli to high densities has been the subject of numerous studies since the early 1970s, exploring the limits of bacterial culture density in order to achieve maximum productivity. Research strategies were focused on improving the cultivation techniques, manipulating the bacteria's physiology or both. As a result, batch, fed batch and dialysis fermentation techniques had been developed. These growth strategies, together with optimization of media composition and the application of molecular biology methods, made it possible to grow E. coli to cell densities of up to 190 g/l (dry weight), while avoiding media precipitation and preventing acetate accumulation. Additional research on the effects of heterologous protein biosynthesis on signal transduction, proteolysis and post transcription events in E. coli may improve its productivity.E. coli is the major bacterial platform for expressing simple heterologous proteins. Growing E. coli to high densities has been the subject of numerous studies since the early 1970s, exploring the limits of bacterial culture density in order to achieve maximum productivity. Research strategies were focused on improving the cultivation techniques, manipulating the bacteria's physiology or both. As a result, batch, fed batch and dialysis fermentation techniques had been developed. These growth strategies, together with optimization of media composition and the application of molecular biology methods, made it possible to grow E. coli to cell densities of up to 190 g/l (dry weight), while avoiding media precipitation and preventing acetate accumulation. Additional research on the effects of heterologous protein biosynthesis on signal transduction, proteolysis and post transcription events in E. coli may improve its productivity. E. coli is the major bacterial platform for expressing simple heterologous proteins. Growing E. coli to high densities has been the subject of numerous studies since the early 1970s, exploring the limits of bacterial culture density in order to achieve maximum productivity. Research strategies were focused on improving the cultivation techniques, manipulating the bacteria's physiology or both. As a result, batch, fed batch and dialysis fermentation techniques had been developed. These growth strategies, together with optimization of media composition and the application of molecular biology methods, made it possible to grow E. coli to cell densities of up to 190 g/l (dry weight), while avoiding media precipitation and preventing acetate accumulation. Additional research on the effects of heterologous protein biosynthesis on signal transduction, proteolysis and post transcription events in E. coli may improve its productivity. |
| Author | Shiloach, Joseph Fass, Rephael |
| Author_xml | – sequence: 1 givenname: Joseph surname: Shiloach fullname: Shiloach, Joseph email: yossi@nih.gov organization: Biotechnology Unit, Bldg. 14A Rm. 173, NIDDK, NIH Bethesda, MD 20892-5522, USA – sequence: 2 givenname: Rephael surname: Fass fullname: Fass, Rephael organization: Department of Biotechnology, IIBR, Ness-Ziona 74100, Israel |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16837065$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15899573$$D View this record in MEDLINE/PubMed |
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| Keywords | Growth strategies Acetate excretion High density E. coli Excretion Growth Acetate Method Cell density |
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| Snippet | E. coli is the major bacterial platform for expressing simple heterologous proteins. Growing
E. coli to high densities has been the subject of numerous studies... E. coli is the major bacterial platform for expressing simple heterologous proteins. Growing E. coli to high densities has been the subject of numerous studies... |
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| SubjectTerms | Acetate excretion Biological and medical sciences Bioreactors - microbiology Biotechnology Cell Count Cell Culture Techniques - methods Cell Proliferation E. coli Escherichia coli - growth & development Escherichia coli - metabolism Escherichia coli Proteins - biosynthesis Fundamental and applied biological sciences. Psychology Growth strategies High density Models, Biological Protein Engineering - methods Recombinant Proteins - biosynthesis |
| Title | Growing E. coli to high cell density—A historical perspective on method development |
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