Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population

• Published in: JCI insight Vol. 6; no. 8
• Main Authors: DePianto, Daryle J, Heiden, Jason A Vander, Morshead, Katrina B, Sun, Kai-Hui, Modrusan, Zora, Teng, Grace, Wolters, Paul J, Arron, Joseph R
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 22.04.2021; American Society for Clinical investigation
• Subjects: Aged; Aging; Case-Control Studies; Cellular Senescence - genetics; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Epithelial Cells - metabolism; Female; Humans; Idiopathic Pulmonary Fibrosis - genetics; Idiopathic Pulmonary Fibrosis - metabolism; Idiopathic Pulmonary Fibrosis - pathology; Keratin-17 - metabolism; Keratin-5 - metabolism; Lung; Lung Diseases, Interstitial - etiology; Lung Diseases, Interstitial - genetics; Lung Diseases, Interstitial - metabolism; Lung Diseases, Interstitial - pathology; Male; Middle Aged; Pulmonology; Respiratory Mucosa; RNA-Seq; Scleroderma, Systemic - complications; Scleroderma, Systemic - genetics; Scleroderma, Systemic - metabolism; Scleroderma, Systemic - pathology; Single-Cell Analysis; Transcriptome; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Pulmonology; Aging; Cellular senescence; Fibrosis

Compromised regenerative capacity of lung epithelial cells can lead to cellular senescence, which may precipitate fibrosis. While increased markers of senescence have been reported in idiopathic pulmonary fibrosis (IPF), the origin and identity of these senescent cells remain unclear, and tools to c...