Cyclophilin A causes severe fever with thrombocytopenia syndrome virus-induced cytokine storm by regulating mitogen-activated protein kinase pathway

• Published in: Frontiers in microbiology Vol. 13; p. 1046176
• Main Authors: Huang, Huaying, Jin, Ke, Ouyang, Ke, Jiang, Zhengyi, Yang, Zhan, Hu, Nannan, Dai, Yan, Zhang, Yaqin, Zhang, Qian, Han, Ying, Zhao, Jie, Lin, Hong, Wang, Chunhui, Wang, Chunyan, Sun, Xuewei, Lu, Dafeng, Zhu, Jin, Li, Jun
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.12.2022
• Subjects: Cyclophilin A; Cyclosporine A; infection; Microbiology; mitogen-activated protein kinase; severe fever with thrombocytopenia syndrome; mitogen-activated protein kinase; Cyclosporine A; severe fever with thrombocytopenia syndrome; infection; Cyclophilin A

Severe fever with thrombocytopenia syndrome (SFTS) has become a global threat to public health since its first report in China in 2009. However, the pathogenesis of SFTS virus (SFTSV) in humans remains unclear. Also, there are no effective therapeutics for SFTS. Cyclophilin A (CyPA) regulates protei...