Oxidised fish oil does not influence established markers of oxidative stress in healthy human subjects: a randomised controlled trial

• Published in: British journal of nutrition Vol. 108; no. 2; pp. 315 - 326
• Main Authors: Ottestad, Inger, Vogt, Gjermund, Retterstøl, Kjetil, Myhrstad, Mari C., Haugen, John-Erik, Nilsson, Astrid, Ravn-Haren, Gitte, Nordvi, Berit, Brønner, Kirsti W., Andersen, Lene F., Holven, Kirsten B., Ulven, Stine M.
• Format: Journal Article
• Language: English
• Published: Cambridge Cambridge University Press 28.07.2012
• Subjects: Adult; Aldehydes - blood; alpha-tocopherol; alpha-Tocopherol - blood; Biological and medical sciences; Biomarkers - blood; Biomarkers - urine; blood serum; C-reactive protein; C-Reactive Protein - analysis; Cardiovascular disease; Clinical outcomes; Cod Liver Oil - adverse effects; Cod Liver Oil - chemistry; Dietary Supplements - adverse effects; Dietary Supplements - analysis; Dinoprost - analogs & derivatives; Dinoprost - urine; Double-Blind Method; enzyme activity; erythrocytes; Erythrocytes - enzymology; fasting; Fatty Acids, Omega-3 - administration & dosage; Fatty Acids, Omega-3 - blood; Feeding. Feeding behavior; Female; Fish; fish consumption; Fish oils; Fundamental and applied biological sciences. Psychology; Helianthus; Humans; inflammation; Lipid Peroxidation; Male; Norway; Nutrition research; omega-3 fatty acids; oxidation; Oxidation-Reduction; Oxidative Stress; Oxidoreductases - blood; Patient Dropouts; Peroxidation; randomized clinical trials; Risk reduction; Sunflower oil; urine; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Young Adult; Human; Oxidative stress; Vertebrata; Mammalia; Healthy subject; n-3; Lipid peroxidation; Lipids; Marker; Oxidised oil; Fish oil; Peroxidation

Intake of fish oil reduces the risk of CHD and CHD deaths. Marine n -3 fatty acids (FA) are susceptible to oxidation, but to our knowledge, the health effects of intake of oxidised fish oil have not previously been investigated in human subjects. The aim of the present study was to investigate marke...