Sublingual Immunotherapy for Experimental Allergic Conjunctivitis in a Murine Model Induced by Dermatophagoides farinae Allergen

• Published in: International archives of allergy and immunology Vol. 161; no. 3; pp. 205 - 212
• Main Authors: Liu, Li-lin, Guo, Dan-dan, Liang, Qiao-xia, Ding, Shan, Chen, Jing-ya, Wu, Bing, Li, Qin
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2013
• Subjects: Administration, Sublingual; Allergies; Animals; Anti-Allergic Agents - therapeutic use; Antigens, Dermatophagoides - immunology; Antigens, Dermatophagoides - therapeutic use; Arthropod Proteins - immunology; Arthropod Proteins - therapeutic use; Conjunctiva - pathology; Conjunctivitis, Allergic - immunology; Conjunctivitis, Allergic - therapy; Cysteine Endopeptidases - immunology; Cysteine Endopeptidases - therapeutic use; Cytokines; Dermatophagoides farinae; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin E - blood; Immunoglobulins; Immunotherapy; Immunotherapy, Active; Interleukin-4 - blood; Mice; Mice, Inbred BALB C; Original Paper; Th2 Cells - cytology; Allergic conjunctivitis; Interleukin-4; Interferon-γ; Dermatophagoides farinae; Immunoglobulin G; Immunoglobulin E; Sublingual immunotherapy; Murine model

Background: Sublingual immunotherapy (SLIT) is a clinically effective treatment in allergic conjunctivitis (AC); however, the mechanism of the underlying pharmacodynamics remains unclear. Here, we investigate the efficacy and the mechanism of a sublingually administered Dermatophagoides farinae (Der...