Negative Regulation of BOK Expression by Recruitment of TRIM28 to Regulatory Elements in Its 3′ Untranslated Region

• Published in: iScience Vol. 9; pp. 461 - 474
• Main Authors: Fernandez-Marrero, Yuniel, Bachmann, Daniel, Lauber, Emanuel, Kaufmann, Thomas
• Format: Journal Article
• Language: English
• Published: United States Elsevier 30.11.2018
• Subjects: Molecular Mechanism of Gene Regulation; Cancer

BCL-2-related ovarian killer (BOK) is a pro-apoptotic BAX-like member of the BCL-2 family with suggested tumor suppressor activity. The molecular mechanisms regulating BOK expression are poorly understood and fail to explain a frequent lack of concordance between protein and transcript levels. Here,...