Combination of PLGA nanoparticles with mucoadhesive guar-gum films for buccal delivery of antihypertensive peptide

• Published in: International journal of pharmaceutics Vol. 547; no. 1-2; pp. 593 - 601
• Main Authors: Castro, Pedro M., Baptista, Patrícia, Madureira, Ana Raquel, Sarmento, Bruno, Pintado, Manuela E.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 25.08.2018; Elsevier
• Subjects: Antihypertensive peptide; Buccal delivery; Guar-gum films; PLGA nanoparticles; Whey protein; Guar-gum films; Antihypertensive peptide; Whey protein; Buccal delivery; PLGA nanoparticles

[Display omitted] Oral administration of proteins and peptides still is a challenging task to overcome due to low permeability through absorptive epithelia, degradation and metabolism that lead to poor bioavailability. Attempting to overcome such limitations, an antihypertensive peptide derived from...