Selective Vulnerability of the Locus Coeruleus Noradrenergic System and its Role in Modulation of Neuroinflammation, Cognition, and Neurodegeneration

• Published in: Frontiers in pharmacology Vol. 13; p. 1030609
• Main Authors: Evans, Andrew K., Defensor, Erwin, Shamloo, Mehrdad
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.11.2022
• Subjects: beta-adrenergic; locus coeruleus; neurodegeneration; neuroinflammation; noradrenaline; oxidative stress; Pharmacology; Alzheimer’s disease; neuroinflammation; neurodegeneration; noradrenaline; beta-adrenergic; locus coeruleus; oxidative stress

Locus coeruleus (LC) noradrenergic (NE) neurons supply the main adrenergic input to the forebrain. NE is a dual modulator of cognition and neuroinflammation. NE neurons of the LC are particularly vulnerable to degeneration both with normal aging and in neurodegenerative disorders. Consequences of th...