The role of microglia in prion diseases and possible therapeutic targets: a literature review

• Published in: Prion Vol. 15; no. 1; pp. 191 - 206
• Main Authors: de Melo, Ananda Sampaio Lamenha Falcão, Lima, Juliana Louise Dias, Malta, Maria Carolina Silva, Marroquim, Natália França, Moreira, Álvaro Rivelli, de Almeida Ladeia, Isabelle, dos Santos Cardoso, Fabrizio, Gonçalves, Daniel Buzaglo, Dutra, Bruna Guimarães, dos Santos, Júlio César Claudino
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.01.2021
• Subjects: Creutzfeldt-Jakob disease; Creutzfeldt-Jakob Syndrome - metabolism; Cytokines - metabolism; Humans; microglia; Microglia - metabolism; neuroinflammation pathways; Prion Diseases - metabolism; Prion Diseases - therapy; Prions - metabolism; Review; microglia; neuroinflammation pathways; Creutzfeldt-Jakob disease

Creutzfeldt-Jakob disease (CJD) is a rare and fatal condition that leads to progressive neurodegeneration due to gliosis, vacuolation of central nervous system tissue, and loss of neurons. Microglia play a crucial role in maintaining Central Nervous System (CNS) homoeostasis, both in health and dise...