Cholesterol and Hematopoietic Stem Cells: Inflammatory Mediators of Atherosclerosis

• Published in: Stem cells translational medicine Vol. 3; no. 5; pp. 549 - 552
• Main Authors: Lang, Jennifer K., Cimato, Thomas R.
• Format: Journal Article
• Language: English
• Published: Durham, NC, USA AlphaMed Press 01.05.2014; Oxford University Press
• Subjects: Acute coronary syndromes; Animals; Antagonism; Arteriosclerosis; Atherosclerosis; Atherosclerosis - blood; Atherosclerosis - pathology; Bone marrow; Cardiovascular disease; Cholesterol; Cholesterol - blood; Coronary vessels; Cytokines - blood; Heart attacks; Hematopoietic stem cells; Hematopoietic Stem Cells - metabolism; Hematopoietic Stem Cells - pathology; Human subjects; Humans; Inflammation; Inflammation Mediators - blood; Investigations; Low density lipoprotein; Mice; Monocytes - metabolism; Monocytes - pathology; Neutrophils; Neutrophils - metabolism; Neutrophils - pathology; Prevention; Spleen; Stem cell transplantation; Stem cells; Stroke

Recent findings have provided new insight into the interaction among hematopoietic stem cells (HSPCs), cholesterol, and atherosclerosis. The authors review studies in mice and consider the connection in humans between cholesterol and HSPCs. Recent studies represent an important avenue to determine w...