Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer

• Published in: Cancer science Vol. 114; no. 4; pp. 1256 - 1269
• Main Authors: Minohara, Kiyoshi, Imai, Masaki, Matoba, Takuma, Wing, James Badger, Shime, Hiroaki, Odanaka, Mizuyu, Uraki, Ryuta, Kawakita, Daisuke, Toyama, Tatsuya, Takahashi, Satoru, Morita, Akimichi, Murakami, Shingo, Ohkura, Naganari, Sakaguchi, Shimon, Iwasaki, Shinichi, Yamazaki, Sayuri
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2023; John Wiley and Sons Inc
• Subjects: Algorithms; Apoptosis; Approximation; Breast cancer; CD8 antigen; CD8-Positive T-Lymphocytes; Cell surface; CTLA-4 protein; Cytokines; Datasets; Dendritic Cells; Effector cells; Flow cytometry; Gene expression; Genomes; Head & neck cancer; Head and neck carcinoma; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - metabolism; head and neck squamous cell carcinoma (HNSCC); Helper cells; Human papillomavirus; Humans; IL‐17; Immunoregulation; Interleukin 17; Lymphatic system; Lymphocytes; Lymphocytes T; mature dendritic cells enriched in regulatory molecules (mregDCs); Medical prognosis; Melanoma; Metastasis; Ontology; Original; ORIGINAL ARTICLES; Patients; Phenotypes; Principal components analysis; Prognosis; Quality control; regulatory T (Treg) cells; Skin cancer; Squamous cell carcinoma; Squamous Cell Carcinoma of Head and Neck - metabolism; T-Lymphocytes, Regulatory; Tumor Microenvironment; Tumors; mature dendritic cells enriched in regulatory molecules (mregDCs); regulatory T (Treg) cells; head and neck squamous cell carcinoma (HNSCC); IL-17

We previously reported that regulatory T (Treg) cells expressing CTLA‐4 on the cell surface are abundant in head and neck squamous cell carcinoma (HNSCC). The role of expanded Treg cells in the tumor microenvironment of HNSCC remains unclear. In this study, we reveal that the tumor microenvironment...