Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy

• Published in: Circulation (New York, N.Y.) Vol. 142; no. 12; pp. 1176 - 1189
• Main Authors: Nicolai, Leo, Leunig, Alexander, Brambs, Sophia, Kaiser, Rainer, Weinberger, Tobias, Weigand, Michael, Muenchhoff, Maximilian, Hellmuth, Johannes C., Ledderose, Stephan, Schulz, Heiko, Scherer, Clemens, Rudelius, Martina, Zoller, Michael, Höchter, Dominik, Keppler, Oliver, Teupser, Daniel, Zwißler, Bernhard, von Bergwelt-Baildon, Michael, Kääb, Stefan, Massberg, Steffen, Pekayvaz, Kami, Stark, Konstantin
• Format: Journal Article
• Language: English
• Published: United States by the American College of Cardiology Foundation and the American Heart Association, Inc 22.09.2020; Lippincott Williams & Wilkins
• Subjects: Betacoronavirus - genetics; Betacoronavirus - isolation & purification; Blood Coagulation Disorders - diagnosis; Blood Coagulation Disorders - etiology; Blood Platelets - cytology; Blood Platelets - metabolism; Blood Platelets - pathology; Case-Control Studies; Coronavirus Infections - complications; Coronavirus Infections - diagnosis; Coronavirus Infections - pathology; Coronavirus Infections - virology; COVID-19; Extracellular Traps - metabolism; Humans; Kidney - pathology; Lung - pathology; Neutrophils - cytology; Neutrophils - metabolism; Neutrophils - pathology; Original s; Pandemics; Phenotype; Platelet Activation; Pneumonia, Viral - complications; Pneumonia, Viral - diagnosis; Pneumonia, Viral - pathology; Pneumonia, Viral - virology; Respiratory Insufficiency - diagnosis; Respiratory Insufficiency - etiology; SARS-CoV-2; Severity of Illness Index; Thrombosis - complications; Thrombosis - diagnosis; COVID-19; blood platelets; thrombosis; severe acute respiratory syndrome coronavirus 2; disseminated intravascular coagulation; neutrophils; respiratory insufficiency

Severe acute respiratory syndrome corona virus 2 infection causes severe pneumonia (coronavirus disease 2019 [COVID-19]), but the mechanisms of subsequent respiratory failure and complicating renal and myocardial involvement are poorly understood. In addition, a systemic prothrombotic phenotype has...