A Theranostic Cellulose Nanocrystal‐Based Drug Delivery System with Enhanced Retention in Pulmonary Metastasis of Melanoma

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 17; no. 18; pp. e2007705 - n/a
• Main Authors: Imlimthan, Surachet, Khng, You Cheng, Keinänen, Outi, Zhang, Wenzhong, Airaksinen, Anu J., Kostiainen, Mauri A., Zeglis, Brian M., Santos, Hélder A., Sarparanta, Mirkka
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.05.2021
• Subjects: Animals; Capillaries; Cell Line, Tumor; Cellulose; cellulose nanocrystal; Computed tomography; drug delivery system; Drug Delivery Systems; Humans; Lungs; Lutetium; Lutetium isotopes; Lutetium‐177; Melanoma; Melanoma - drug therapy; Metastasis; metastatic melanoma; Mice; Mutation; Nanocrystals; Nanoparticles; Nanotechnology; Payloads; Photon emission; Precision Medicine; Radiation therapy; Spleen; Survival; theranostic nanosystem; Tissue Distribution; vemurafenib; vemurafenib; theranostic nanosystem; drug delivery system; cellulose nanocrystal; metastatic melanoma; Lutetium-177

Metastatic melanoma can be difficult to detect until at the advanced state that decreases the survival rate of patients. Several FDA‐approved BRAF inhibitors have been used for treatment of metastatic melanoma, but overall therapeutic efficacy has been limited. Lutetium‐177 (177Lu) enables simultane...