Tricepyridinium‐inspired QACs yield potent antimicrobials and provide insight into QAC resistance

• Published in: ChemMedChem Vol. 16; no. 3; pp. 463 - 466
• Main Authors: Garrison, Michelle A., Mahoney, Andrew R., Wuest, William M.
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 04.02.2021; Wiley Subscription Services, Inc
• Subjects: Alkyl compounds; Ammonium; ammonium compound; Ammonium compounds; Analogs; Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial; Antimicrobial agents; antiseptic; Benzalkonium chloride; Biological analysis; Cetylpyridinium chloride; Chemistry, Medicinal; Chlorides; Consumer products; Disinfectants; Dose-Response Relationship, Drug; Drug resistance; Escherichia coli - drug effects; Indoles - chemistry; Indoles - pharmacology; Liability; Life Sciences & Biomedicine; Microbial Sensitivity Tests; Models, Molecular; Molecular modelling; Molecular Structure; MRSA; natural product; Natural products; Pharmacology & Pharmacy; Pseudomonas aeruginosa - drug effects; Pyridinium Compounds - chemistry; Pyridinium Compounds - pharmacology; Quaternary ammonium compounds; Quaternary Ammonium Compounds - chemistry; Quaternary Ammonium Compounds - pharmacology; Quaternary ammonium salts; Science & Technology; Selectivity; Staphylococcus - drug effects; Structure-Activity Relationship; antiseptic; ammonium compound; INFECTIONS; DISINFECTANTS; natural product; MRSA; Antibacterial

Quaternary ammonium compounds (QACs) comprise a large class of surfactants, consumer products, and disinfectants. The recently‐isolated QAC natural product tricepyridinium bromide displays potent inhibitory activity against S. aureus but due to its unique structure, its mechanism of action remains u...