Direct β‐ and γ‐C(sp3)−H Alkynylation of Free Carboxylic Acids

• Published in: Angewandte Chemie International Edition Vol. 59; no. 51; pp. 23127 - 23131
• Main Authors: Ghiringhelli, Francesca, Uttry, Alexander, Ghosh, Kiron Kumar, Gemmeren, Manuel
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 14.12.2020; Wiley Subscription Services, Inc; John Wiley and Sons Inc
• Edition: International ed. in English
• Subjects: Alkynylation; Carboxylic acids; Chemistry; Chemistry, Multidisciplinary; Communication; Communications; C−H activation; Enantiomers; Ligand-enabled catalysis; Palladium; Physical Sciences; Science & Technology; Substrates; Alkynylation; C(SP)-H BONDS; ACTIVATION; BETA-C(SP)-H ARYLATION; FUNCTIONALIZATIONS; ALPHA-AMINO-ACIDS; Palladium; Carboxylic acids; C-H BONDS; C-H activation; CATALYZED DIRECT ETHYNYLATION; DERIVATIVES; SP; Ligand-enabled catalysis; C−H activation

In this study we report the identification of a novel class of ligands for palladium‐catalyzed C(sp3)−H activation that enables the direct alkynylation of free carboxylic acid substrates. In contrast to previous synthetic methods, no introduction/removal of an exogenous directing group is required....