IL-12 and IL-23: master regulators of innate and adaptive immunity
Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine biology have led to an increased understanding of how myeloid cell‐derived factors regulate the immune system to protect the host from infections and...
Saved in:
| Published in | Immunological reviews Vol. 202; no. 1; pp. 96 - 105 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK; Malden, USA
Munksgaard International Publishers
01.12.2004
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine biology have led to an increased understanding of how myeloid cell‐derived factors regulate the immune system to protect the host from infections and prevent tumor development. In this review, we focus on the function of interleukin (IL)‐23, a new member of the IL‐12 family of regulatory cytokines produced by activated macrophages and dendritic cells. We propose that IL‐12 and IL‐23 promote two distinct immunological pathways that have separate but complementary functions. IL‐12 is required for antimicrobial responses to intracellular pathogens, whereas IL‐23 is likely to be important for the recruitment and activation of a range of inflammatory cells that is required for the induction of chronic inflammation and granuloma formation. These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression. |
|---|---|
| AbstractList | Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine biology have led to an increased understanding of how myeloid cell‐derived factors regulate the immune system to protect the host from infections and prevent tumor development. In this review, we focus on the function of interleukin (IL)‐23, a new member of the IL‐12 family of regulatory cytokines produced by activated macrophages and dendritic cells. We propose that IL‐12 and IL‐23 promote two distinct immunological pathways that have separate but complementary functions. IL‐12 is required for antimicrobial responses to intracellular pathogens, whereas IL‐23 is likely to be important for the recruitment and activation of a range of inflammatory cells that is required for the induction of chronic inflammation and granuloma formation. These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression. Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine biology have led to an increased understanding of how myeloid cell-derived factors regulate the immune system to protect the host from infections and prevent tumor development. In this review, we focus on the function of interleukin (IL)-23, a new member of the IL-12 family of regulatory cytokines produced by activated macrophages and dendritic cells. We propose that IL-12 and IL-23 promote two distinct immunological pathways that have separate but complementary functions. IL-12 is required for antimicrobial responses to intracellular pathogens, whereas IL-23 is likely to be important for the recruitment and activation of a range of inflammatory cells that is required for the induction of chronic inflammation and granuloma formation. These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression.Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine biology have led to an increased understanding of how myeloid cell-derived factors regulate the immune system to protect the host from infections and prevent tumor development. In this review, we focus on the function of interleukin (IL)-23, a new member of the IL-12 family of regulatory cytokines produced by activated macrophages and dendritic cells. We propose that IL-12 and IL-23 promote two distinct immunological pathways that have separate but complementary functions. IL-12 is required for antimicrobial responses to intracellular pathogens, whereas IL-23 is likely to be important for the recruitment and activation of a range of inflammatory cells that is required for the induction of chronic inflammation and granuloma formation. These two cytokines work in concert to regulate cellular immune responses critical for host defense and tumor suppression. |
| Author | Langrish, Claire L. Wilson, Nicholas J. McKenzie, Brent S. Kastelein, Robert A. Cua, Daniel J. De Waal Malefyt, Rene |
| Author_xml | – sequence: 1 givenname: Claire L. surname: Langrish fullname: Langrish, Claire L. organization: Discovery Research, DNAX Research Inc., Palo Alto, CA, USA – sequence: 2 givenname: Brent S. surname: McKenzie fullname: McKenzie, Brent S. organization: Discovery Research, DNAX Research Inc., Palo Alto, CA, USA – sequence: 3 givenname: Nicholas J. surname: Wilson fullname: Wilson, Nicholas J. organization: Experimental Pharmacology and Pathology, DNAX Research Inc., Palo Alto, CA, USA – sequence: 4 givenname: Rene surname: De Waal Malefyt fullname: De Waal Malefyt, Rene organization: Experimental Pharmacology and Pathology, DNAX Research Inc., Palo Alto, CA, USA – sequence: 5 givenname: Robert A. surname: Kastelein fullname: Kastelein, Robert A. organization: Discovery Research, DNAX Research Inc., Palo Alto, CA, USA – sequence: 6 givenname: Daniel J. surname: Cua fullname: Cua, Daniel J. email: daniel.cua@dnax.org organization: Discovery Research, DNAX Research Inc., Palo Alto, CA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/15546388$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkU2P0zAQhi20iO0u_AWUE7cEO_6IgxASrGCpVEAgoIjLyHEmyCUfxXag_fe426UHLuCL5_C878y8c0HOxmlEQjJGC5be401BGZV5qWtVlJSKgtKSiWJ3hyyYojSnSn45I4sTdE4uQthQyipeinvknEkpFNd6QV4sVzkrMzO2WapK_iQbTIjoM4_f5t7EyYds6jI3jibiDWZas43uJ2ZuGObRxf19crczfcAHt_8l-fTq5cer1_nq3fXy6vkqt0JpkZcNbyzajrXI0mC2lVrXaTiUylrFKNa6402NtbSqsV1biarhtpJdaihsq_kleXT03frpx4whwuCCxb43I05zAFXRqlZcJfDhLTg3A7aw9W4wfg9_tk7AsyNg_RSCxw6siya6aYzeuB4YhUPMsIFDgnBIEA4xw03MsEsG-i-DU49_S58epb9cj_v_1sHyzYdUJHl-lLt0pd1Jbvz3tD-vJKzfXgMV6_fis_gKa_4bdsyhwA |
| CitedBy_id | crossref_primary_10_1002_hbm_23252 crossref_primary_10_1016_j_diabres_2010_03_014 crossref_primary_10_1097_SHK_0000000000000207 crossref_primary_10_3389_fmicb_2017_01393 crossref_primary_10_1111_jdv_14868 crossref_primary_10_1007_s11926_021_01027_5 crossref_primary_10_1155_2012_715190 crossref_primary_10_1016_j_molimm_2006_09_001 crossref_primary_10_1155_2022_2944156 crossref_primary_10_1177_0218492309338100 crossref_primary_10_1177_1759720X20977777 crossref_primary_10_1007_s40744_015_0010_2 crossref_primary_10_1016_j_micinf_2005_09_007 crossref_primary_10_1002_ibd_20463 crossref_primary_10_1016_j_jaut_2018_11_002 crossref_primary_10_1038_s41598_018_23539_4 crossref_primary_10_2174_1389450121666191218123203 crossref_primary_10_4049_jimmunol_176_11_6802 crossref_primary_10_1016_j_smim_2005_05_010 crossref_primary_10_1097_CJI_0b013e318193d31e crossref_primary_10_1164_rccm_200911_1775OC crossref_primary_10_1002_eji_200636643 crossref_primary_10_1155_2016_3463104 crossref_primary_10_1371_journal_pone_0030434 crossref_primary_10_3389_fimmu_2024_1435054 crossref_primary_10_1016_j_jneuroim_2006_03_020 crossref_primary_10_1586_1744666X_2014_883920 crossref_primary_10_1016_j_bbrc_2010_02_153 crossref_primary_10_3389_fnins_2024_1451060 crossref_primary_10_3389_fphar_2020_00129 crossref_primary_10_1016_j_cellimm_2015_01_015 crossref_primary_10_1080_1744666X_2018_1532291 crossref_primary_10_2527_jas_2008_1187 crossref_primary_10_1371_journal_pone_0074108 crossref_primary_10_1111_j_1365_2249_2006_03215_x crossref_primary_10_1371_journal_pone_0074225 crossref_primary_10_1111_j_1365_2567_2007_02601_x crossref_primary_10_1016_j_lungcan_2012_10_003 crossref_primary_10_1016_j_cmpb_2008_06_002 crossref_primary_10_1111_aji_13055 crossref_primary_10_3390_medicina57111251 crossref_primary_10_1016_j_pharmthera_2006_12_004 crossref_primary_10_1111_j_1600_065X_2011_01037_x crossref_primary_10_1016_j_psychres_2006_08_005 crossref_primary_10_1038_mt_2008_121 crossref_primary_10_1038_mi_2008_7 crossref_primary_10_1371_journal_pone_0132348 crossref_primary_10_1080_02648725_2013_801228 crossref_primary_10_1089_jir_2023_0190 crossref_primary_10_1089_scd_2017_0025 crossref_primary_10_1007_s00535_006_1926_7 crossref_primary_10_1073_pnas_1121231109 crossref_primary_10_1097_BOR_0b013e328303204b crossref_primary_10_1016_j_jaci_2010_12_002 crossref_primary_10_1016_j_clim_2008_01_019 crossref_primary_10_1111_aji_13064 crossref_primary_10_23736_S0026_4806_23_08466_5 crossref_primary_10_1038_s41598_017_17752_w crossref_primary_10_4049_jimmunol_175_12_7905 crossref_primary_10_1111_j_1574_695X_2007_00233_x crossref_primary_10_4049_jimmunol_177_9_6122 crossref_primary_10_1155_2014_590409 crossref_primary_10_2147_IJN_S250960 crossref_primary_10_1007_s00430_015_0440_z crossref_primary_10_1159_000536601 crossref_primary_10_1177_0961203313498799 crossref_primary_10_1016_j_jmb_2008_08_001 crossref_primary_10_1016_j_bbrc_2010_10_114 crossref_primary_10_3390_biologics1020012 crossref_primary_10_1016_j_imbio_2007_11_007 crossref_primary_10_1016_j_bbi_2010_05_003 crossref_primary_10_4049_jimmunol_180_8_5157 crossref_primary_10_1016_S1016_8478_23_13229_8 crossref_primary_10_1186_1472_6807_12_22 crossref_primary_10_3390_ijms19113605 crossref_primary_10_1038_nrrheum_2012_170 crossref_primary_10_1097_MD_0000000000000613 crossref_primary_10_1038_cr_2009_128 crossref_primary_10_1371_journal_pone_0055756 crossref_primary_10_1371_journal_pone_0245169 crossref_primary_10_1111_j_1365_2567_2011_03522_x crossref_primary_10_1016_j_bbrep_2023_101438 crossref_primary_10_1002_art_33494 crossref_primary_10_1177_1753425916669862 crossref_primary_10_1074_jbc_M710013200 crossref_primary_10_1016_j_cmi_2018_02_002 crossref_primary_10_2174_1381612825666190405141410 crossref_primary_10_1017_S003118201400095X crossref_primary_10_1371_journal_pone_0141265 crossref_primary_10_1038_sj_icb_7100027 crossref_primary_10_1111_aji_13016 crossref_primary_10_1155_2008_349185 crossref_primary_10_1155_2013_425915 crossref_primary_10_1038_sj_icb_7100146 crossref_primary_10_1186_1477_7827_7_84 crossref_primary_10_1371_journal_ppat_1000836 crossref_primary_10_1371_journal_pone_0181449 crossref_primary_10_1136_annrheumdis_2016_209351 crossref_primary_10_1128_JVI_00315_09 crossref_primary_10_1371_journal_pone_0071905 crossref_primary_10_1093_infdis_jir336 crossref_primary_10_1128_IAI_00971_07 crossref_primary_10_1182_blood_2006_09_045641 crossref_primary_10_1182_blood_2008_08_175448 crossref_primary_10_1002_ibd_20523 crossref_primary_10_1016_j_livsci_2015_05_007 crossref_primary_10_1021_jm801365a crossref_primary_10_3390_cancers2020436 crossref_primary_10_1038_srep12946 crossref_primary_10_1016_j_cyto_2014_11_003 crossref_primary_10_1038_ni0307_232 crossref_primary_10_3390_molecules21101321 crossref_primary_10_4049_jimmunol_1601549 crossref_primary_10_1128_IAI_73_9_5782_5788_2005 crossref_primary_10_1016_j_vaccine_2011_04_090 crossref_primary_10_1196_annals_1406_032 crossref_primary_10_1038_sj_ki_5002196 crossref_primary_10_1007_s00251_014_0796_z crossref_primary_10_1002_hep_21340 crossref_primary_10_4078_jrd_2023_0041 crossref_primary_10_1146_annurev_immunol_030409_101225 crossref_primary_10_1016_j_micinf_2012_03_005 crossref_primary_10_1084_jem_20061082 crossref_primary_10_1189_jlb_1009652 crossref_primary_10_1371_journal_pntd_0005684 crossref_primary_10_1016_j_micinf_2009_03_005 crossref_primary_10_1097_MD_0000000000003772 crossref_primary_10_1016_j_cyto_2008_07_017 crossref_primary_10_1007_s10753_016_0453_9 crossref_primary_10_1371_journal_pone_0105351 crossref_primary_10_1016_j_crohns_2013_08_002 crossref_primary_10_1084_jem_20050193 crossref_primary_10_1111_1365_2435_12273 crossref_primary_10_4049_jimmunol_1700655 crossref_primary_10_1080_09546630802206686 crossref_primary_10_1093_jmcb_mjp001 crossref_primary_10_1111_j_1365_2249_2009_03961_x crossref_primary_10_1016_j_cellimm_2006_11_002 crossref_primary_10_4049_jimmunol_177_6_4072 crossref_primary_10_3892_mmr_2022_12824 crossref_primary_10_1016_j_freeradbiomed_2015_02_003 crossref_primary_10_3389_fimmu_2017_00044 crossref_primary_10_1177_1535370218824547 crossref_primary_10_1093_bioinformatics_bty556 crossref_primary_10_1016_j_ebiom_2017_08_001 crossref_primary_10_1021_acsmacrolett_2c00742 crossref_primary_10_1038_jid_2011_304 crossref_primary_10_1128_JVI_01877_06 crossref_primary_10_1002_eji_200636484 crossref_primary_10_3389_fimmu_2017_00294 crossref_primary_10_1002_eji_200737395 crossref_primary_10_1002_jcp_26604 crossref_primary_10_1007_s11481_009_9188_9 crossref_primary_10_1111_cei_12441 crossref_primary_10_1038_ni_3347 crossref_primary_10_1111_j_1365_3083_2009_02361_x crossref_primary_10_4049_jimmunol_178_3_1357 crossref_primary_10_1038_gene_2008_31 crossref_primary_10_1097_01_qco_0000224818_42729_67 crossref_primary_10_1128_IAI_00403_09 crossref_primary_10_1158_0008_5472_CAN_05_1682 crossref_primary_10_1016_j_clim_2008_10_011 crossref_primary_10_1016_j_bbi_2013_10_016 crossref_primary_10_1111_1756_185X_12674 crossref_primary_10_4049_jimmunol_178_1_186 crossref_primary_10_1371_journal_pone_0141550 crossref_primary_10_1016_j_fct_2016_07_021 crossref_primary_10_1186_1743_422X_2_59 crossref_primary_10_1038_ni_2366 crossref_primary_10_1111_j_1365_2567_2007_02693_x crossref_primary_10_3858_emm_2008_40_1_130 crossref_primary_10_1016_j_fsi_2015_12_007 crossref_primary_10_1016_j_jaad_2007_04_020 crossref_primary_10_32725_jab_2024_024 crossref_primary_10_1007_s11882_014_0489_6 crossref_primary_10_3347_kjp_2013_51_1_85 crossref_primary_10_3390_vaccines8020250 crossref_primary_10_1016_j_ddstr_2006_08_004 crossref_primary_10_1172_JCI30150 crossref_primary_10_1016_j_jaci_2013_06_049 crossref_primary_10_1155_2016_1693918 crossref_primary_10_3389_fimmu_2023_1234535 crossref_primary_10_1053_j_gastro_2006_11_016 crossref_primary_10_1136_ard_2007_080283 crossref_primary_10_1586_egh_11_107 crossref_primary_10_1016_j_cellimm_2006_04_005 crossref_primary_10_1016_j_fsi_2019_06_028 crossref_primary_10_1186_1743_422X_8_301 crossref_primary_10_4049_jimmunol_1002701 crossref_primary_10_4049_jimmunol_1301759 crossref_primary_10_1155_2022_2249834 crossref_primary_10_1155_2013_164246 crossref_primary_10_1021_ab5001063 crossref_primary_10_1016_j_cyto_2017_10_010 crossref_primary_10_1002_eji_200939325 crossref_primary_10_1038_sj_bmt_1705980 crossref_primary_10_1038_cgt_2008_41 crossref_primary_10_1038_ncomms2113 crossref_primary_10_1080_19768354_2011_630411 crossref_primary_10_1080_13693780802139867 crossref_primary_10_1158_0008_5472_CAN_06_3134 crossref_primary_10_1111_j_1471_4159_2007_04875_x crossref_primary_10_3390_ijms242216095 crossref_primary_10_1080_17474124_2020_1780120 crossref_primary_10_1016_j_abb_2016_03_022 crossref_primary_10_1038_sj_jid_5700167 crossref_primary_10_3168_jds_2009_2392 crossref_primary_10_1128_IAI_05821_11 crossref_primary_10_1155_2008_453120 crossref_primary_10_1038_gene_2008_64 crossref_primary_10_1016_j_cyto_2008_12_019 crossref_primary_10_1158_1535_7163_MCT_15_0706 crossref_primary_10_1097_01_MIB_0000194183_92671_b6 crossref_primary_10_4049_jimmunol_0800471 crossref_primary_10_1016_j_biocel_2008_04_027 crossref_primary_10_1089_jir_2012_0063 crossref_primary_10_1016_j_clim_2020_108641 crossref_primary_10_1111_j_1398_9995_2010_02369_x crossref_primary_10_1186_s12864_015_1733_8 crossref_primary_10_1016_j_cirep_2024_200166 crossref_primary_10_1016_S1016_8478_23_13236_5 crossref_primary_10_1097_MD_0000000000004944 crossref_primary_10_1016_j_ijpara_2013_08_001 crossref_primary_10_1016_j_jep_2025_119415 crossref_primary_10_2165_11595940_000000000_00000 crossref_primary_10_1002_cti2_1304 crossref_primary_10_1007_s00281_011_0257_9 crossref_primary_10_3390_ijms241311096 crossref_primary_10_1016_j_cgh_2007_05_002 crossref_primary_10_1016_j_mce_2016_02_003 crossref_primary_10_1128_JVI_07091_11 crossref_primary_10_18081_ajbm_2333_5106_013_11_4_6 crossref_primary_10_1152_ajpgi_00311_2015 crossref_primary_10_1002_dvdy_21594 crossref_primary_10_1111_cas_14343 crossref_primary_10_1016_j_cytogfr_2011_07_001 crossref_primary_10_1042_CBI20100303 crossref_primary_10_1152_ajpgi_00472_2010 crossref_primary_10_1007_s00011_017_1115_6 crossref_primary_10_1074_jbc_M114_595181 crossref_primary_10_4049_jimmunol_175_6_3920 crossref_primary_10_1016_j_gtc_2017_05_015 crossref_primary_10_1186_s12876_022_02271_4 crossref_primary_10_1038_icb_2013_87 crossref_primary_10_3389_fimmu_2021_637829 crossref_primary_10_1128_IAI_01053_06 crossref_primary_10_1002_ueg2_12305 crossref_primary_10_1002_oby_20642 crossref_primary_10_1038_s41551_022_00888_0 crossref_primary_10_1080_21645515_2015_1026498 crossref_primary_10_1016_j_cyto_2007_11_013 crossref_primary_10_1016_j_jaut_2015_04_006 crossref_primary_10_1371_journal_ppat_1005561 crossref_primary_10_4049_jimmunol_181_12_8576 crossref_primary_10_2165_11538950_000000000_00000 crossref_primary_10_3748_wjg_v21_i43_12283 crossref_primary_10_1007_s10620_016_4047_z crossref_primary_10_1016_j_genrep_2021_101422 crossref_primary_10_1016_j_semcdb_2022_01_006 crossref_primary_10_1111_imr_12180 crossref_primary_10_1128_IAI_00161_13 crossref_primary_10_1371_journal_pone_0034349 crossref_primary_10_1016_j_coi_2006_11_008 crossref_primary_10_1152_ajplung_00312_2006 crossref_primary_10_1158_0008_5472_CAN_05_3448 crossref_primary_10_1097_MOG_0000000000000444 crossref_primary_10_1007_s12016_015_8468_9 crossref_primary_10_1080_14740338_2020_1767585 crossref_primary_10_1111_j_1365_2249_2009_03965_x crossref_primary_10_2147_DDDT_S340459 crossref_primary_10_1002_hep_23132 crossref_primary_10_1002_ijc_29182 crossref_primary_10_3748_wjg_v21_i19_6065 crossref_primary_10_3390_jpm11020066 crossref_primary_10_1093_intimm_dxp025 crossref_primary_10_1002_art_23073 crossref_primary_10_1016_j_bbrc_2011_07_013 crossref_primary_10_1038_ni0407_345 crossref_primary_10_1111_j_1365_2567_2006_02513_x crossref_primary_10_4049_jimmunol_0901706 crossref_primary_10_1038_cmi_2016_49 crossref_primary_10_1002_jso_24505 crossref_primary_10_1016_j_ejmech_2013_03_070 crossref_primary_10_1007_s00432_008_0469_0 crossref_primary_10_1124_mol_106_022327 crossref_primary_10_1016_j_cyto_2013_05_013 crossref_primary_10_1038_nm1710 crossref_primary_10_4049_jimmunol_176_1_265 crossref_primary_10_1111_dth_14835 crossref_primary_10_1038_sj_jid_5700807 crossref_primary_10_1089_aid_2010_0012 crossref_primary_10_1155_2020_2369279 crossref_primary_10_1007_s00011_017_1074_y crossref_primary_10_7717_peerj_9952 crossref_primary_10_2147_BTT_S389021 crossref_primary_10_4049_jimmunol_1302091 crossref_primary_10_1586_17469872_2_1_69 crossref_primary_10_5483_BMBRep_2011_44_2_129 crossref_primary_10_1016_j_vetpar_2017_06_010 crossref_primary_10_1111_j_1365_2567_2011_03454_x crossref_primary_10_1111_j_1365_2567_2006_02394_x crossref_primary_10_1016_j_jneuroim_2007_08_011 crossref_primary_10_3945_jn_113_185165 crossref_primary_10_1016_j_immuni_2006_05_017 crossref_primary_10_1016_j_vetimm_2012_08_004 crossref_primary_10_1111_j_1462_5822_2006_00699_x crossref_primary_10_1038_ni1254 crossref_primary_10_1007_s12016_014_8465_4 crossref_primary_10_1097_01_MIB_0000218764_06959_91 crossref_primary_10_1016_j_ejpain_2008_02_003 crossref_primary_10_1038_ijo_2008_216 crossref_primary_10_1016_j_molbiopara_2021_111433 crossref_primary_10_1152_ajpcell_00515_2020 crossref_primary_10_1111_jgh_14962 crossref_primary_10_1177_12034754211049711 crossref_primary_10_4049_jimmunol_178_6_3566 crossref_primary_10_1016_j_addr_2020_10_002 crossref_primary_10_1016_j_molimm_2009_12_008 crossref_primary_10_1016_j_phymed_2024_155917 crossref_primary_10_2217_imt_10_95 crossref_primary_10_3390_cimb46040183 crossref_primary_10_1097_nen_0b013e3181492a7 crossref_primary_10_3390_ijms24032698 crossref_primary_10_1016_j_jtauto_2021_100098 crossref_primary_10_1016_j_cyto_2014_06_020 crossref_primary_10_1126_scitranslmed_aat9143 crossref_primary_10_1016_j_vetimm_2012_01_005 crossref_primary_10_1007_s00383_007_2037_0 crossref_primary_10_1093_intimm_dxp117 crossref_primary_10_1097_MIB_0000000000000353 crossref_primary_10_1007_s11302_006_9034_y crossref_primary_10_4049_jimmunol_179_12_8274 crossref_primary_10_1038_gene_2009_94 crossref_primary_10_1371_journal_ppat_1001289 crossref_primary_10_1074_jbc_M611522200 crossref_primary_10_18632_oncotarget_20319 crossref_primary_10_1007_s10059_013_0268_6 crossref_primary_10_1038_jid_2015_138 crossref_primary_10_1038_nri1648 crossref_primary_10_1128_IAI_00826_18 crossref_primary_10_1038_sj_ki_5002425 crossref_primary_10_1111_j_1365_2249_2011_04447_x crossref_primary_10_4049_jimmunol_1100535 crossref_primary_10_1016_j_cytogfr_2020_06_001 crossref_primary_10_1111_1751_2980_12218 crossref_primary_10_1158_1535_7163_MCT_23_0336 crossref_primary_10_1038_nature04808 crossref_primary_10_1038_ni1223 crossref_primary_10_1007_s00296_009_0893_8 crossref_primary_10_1016_j_jcyt_2012_12_002 crossref_primary_10_1016_j_ddmec_2006_05_006 crossref_primary_10_4161_pri_3_1_8072 crossref_primary_10_1586_1744666X_4_3_301 crossref_primary_10_1111_j_1365_2567_2008_02879_x crossref_primary_10_1007_s00535_011_0521_8 crossref_primary_10_4049_jimmunol_175_7_4706 crossref_primary_10_4049_jimmunol_181_2_1536 crossref_primary_10_1155_2017_4810258 crossref_primary_10_3390_cells10010111 crossref_primary_10_1016_j_jctube_2019_100123 crossref_primary_10_1016_j_jaut_2017_12_007 crossref_primary_10_2353_ajpath_2006_051330 crossref_primary_10_1111_j_1365_2567_2008_02988_x crossref_primary_10_1074_jbc_M709029200 crossref_primary_10_3109_02713683_2013_877489 crossref_primary_10_3389_fphar_2022_921084 crossref_primary_10_4049_jimmunol_177_5_3218 crossref_primary_10_1155_2011_248317 crossref_primary_10_1016_j_intimp_2011_06_010 crossref_primary_10_1586_14787210_4_1_101 crossref_primary_10_1038_s41598_017_14020_9 crossref_primary_10_1016_j_neuroscience_2015_01_012 crossref_primary_10_1017_S0954422424000234 crossref_primary_10_1038_gt_2008_180 crossref_primary_10_1007_s11010_011_1109_6 crossref_primary_10_1093_humrep_del217 crossref_primary_10_1016_j_it_2012_02_008 crossref_primary_10_1007_s00296_008_0770_x crossref_primary_10_4049_jimmunol_178_12_7571 crossref_primary_10_1186_s12890_023_02546_w crossref_primary_10_33084_bjop_v6i2_4217 crossref_primary_10_1080_08916934_2016_1272598 crossref_primary_10_4049_jimmunol_0802046 crossref_primary_10_1089_jir_2007_0037 crossref_primary_10_1189_jlb_1107794 crossref_primary_10_3390_jcm9041028 crossref_primary_10_1039_C6MB00222F crossref_primary_10_1186_ar2893 crossref_primary_10_3390_molecules26103005 crossref_primary_10_1165_rcmb_2011_0134OC crossref_primary_10_1016_j_vaccine_2009_09_058 crossref_primary_10_1038_s41551_020_0549_2 crossref_primary_10_1164_rccm_200512_1886OC crossref_primary_10_1182_blood_2010_01_263509 crossref_primary_10_1007_s12262_013_0957_6 crossref_primary_10_1016_j_jneuroim_2009_11_001 crossref_primary_10_1111_j_1749_6632_2010_05747_x crossref_primary_10_1128_CVI_00078_15 crossref_primary_10_3390_ijms24044002 crossref_primary_10_1371_journal_pone_0029046 crossref_primary_10_1345_aph_1M151 crossref_primary_10_1089_ther_2016_0041 crossref_primary_10_1093_rap_rkae141 crossref_primary_10_1016_j_febslet_2005_10_062 crossref_primary_10_1016_j_jnutbio_2014_03_004 crossref_primary_10_1111_asj_13439 crossref_primary_10_1902_jop_2007_060458 crossref_primary_10_3109_08820139_2014_930477 crossref_primary_10_1371_journal_pntd_0001401 crossref_primary_10_1016_j_ejphar_2016_03_036 crossref_primary_10_1111_j_1399_0039_2007_00881_x crossref_primary_10_1016_j_intimp_2006_09_024 crossref_primary_10_1016_j_jneuroim_2018_10_007 crossref_primary_10_1016_j_jneuroim_2012_02_003 crossref_primary_10_1007_s12011_017_1073_4 crossref_primary_10_1016_j_arcmed_2010_02_011 crossref_primary_10_1038_s41584_023_00984_8 crossref_primary_10_1007_s40265_019_01141_w crossref_primary_10_1084_jem_20061099 crossref_primary_10_1158_1055_9965_EPI_08_0705 crossref_primary_10_1016_j_intimp_2020_107336 crossref_primary_10_1002_ibd_20180 crossref_primary_10_1016_j_clinre_2016_10_005 crossref_primary_10_1371_journal_ppat_1003410 crossref_primary_10_1007_s00441_021_03538_0 crossref_primary_10_1016_j_cyto_2007_09_014 crossref_primary_10_1093_rheumatology_keab461 crossref_primary_10_1590_S0074_02762006000900052 crossref_primary_10_1038_bmt_2010_211 crossref_primary_10_1111_j_1745_7254_2006_00341_x crossref_primary_10_5653_cerm_2011_38_4_193 crossref_primary_10_4049_jimmunol_176_1_309 crossref_primary_10_1016_j_cca_2018_08_022 crossref_primary_10_1016_j_bbmt_2015_03_016 crossref_primary_10_1016_j_arcmed_2010_02_009 crossref_primary_10_1111_j_1365_2567_2007_02754_x crossref_primary_10_1111_j_1440_1843_2010_01819_x crossref_primary_10_1371_journal_pone_0224276 crossref_primary_10_3347_kjp_2017_55_6_613 crossref_primary_10_1152_ajpregu_00540_2013 crossref_primary_10_1074_jbc_M109_025528 crossref_primary_10_1186_1471_2172_10_9 crossref_primary_10_1089_vim_2009_0054 crossref_primary_10_1111_j_1574_695X_2006_00210_x crossref_primary_10_1128_IAI_01329_06 crossref_primary_10_4049_jimmunol_181_11_7473 crossref_primary_10_1016_j_humimm_2012_03_015 crossref_primary_10_1586_ers_12_12 crossref_primary_10_1111_j_1365_3083_2011_02660_x crossref_primary_10_1016_j_actbio_2024_12_056 crossref_primary_10_1097_SHK_0b013e3181e14c2e crossref_primary_10_58803_fahn_v1i2_10 crossref_primary_10_1093_rheumatology_key070 crossref_primary_10_1016_j_kint_2019_05_012 crossref_primary_10_1016_j_vetimm_2008_10_003 crossref_primary_10_3390_ijms23042314 crossref_primary_10_1016_j_smim_2014_10_004 crossref_primary_10_7759_cureus_55459 crossref_primary_10_3389_fcell_2015_00085 crossref_primary_10_1136_gutjnl_2015_309389 crossref_primary_10_1073_pnas_1905762116 crossref_primary_10_1182_blood_2006_04_019711 crossref_primary_10_1016_j_molimm_2005_06_028 crossref_primary_10_1016_j_cellimm_2006_07_001 crossref_primary_10_1111_bjh_13292 crossref_primary_10_2147_OARRR_S295033 crossref_primary_10_4103_err_err_11_17 crossref_primary_10_1016_j_adcanc_2022_100053 crossref_primary_10_1155_2013_374925 crossref_primary_10_3389_fchem_2022_955995 crossref_primary_10_1002_eji_202048936 crossref_primary_10_1186_1471_2334_14_316 crossref_primary_10_1189_jlb_0307166 crossref_primary_10_1016_j_jaci_2010_11_050 crossref_primary_10_4049_jimmunol_178_9_5859 crossref_primary_10_1016_j_placenta_2013_05_007 crossref_primary_10_1053_j_gastro_2007_03_104 crossref_primary_10_1002_ibd_21247 crossref_primary_10_1016_j_jneuroim_2010_09_030 crossref_primary_10_1002_ijc_27640 crossref_primary_10_1016_j_molimm_2011_04_006 crossref_primary_10_1186_1471_2474_14_190 crossref_primary_10_4049_jimmunol_175_1_404 crossref_primary_10_1016_j_jid_2021_06_036 crossref_primary_10_1111_j_1574_695X_2010_00757_x crossref_primary_10_1165_rcmb_2006_0020OC crossref_primary_10_1517_17460441_3_3_357 crossref_primary_10_1016_j_vetimm_2007_01_018 crossref_primary_10_1093_hmg_ddy284 crossref_primary_10_1128_IAI_05641_11 crossref_primary_10_4049_jimmunol_176_2_1098 crossref_primary_10_1146_annurev_immunol_22_012703_104758 crossref_primary_10_4049_jimmunol_0902796 crossref_primary_10_1038_s41401_021_00825_y crossref_primary_10_1016_j_bbrep_2020_100857 crossref_primary_10_1016_j_ajpath_2015_08_015 crossref_primary_10_1136_annrheumdis_2018_213488 crossref_primary_10_1016_j_neulet_2021_135948 crossref_primary_10_1002_jbm_a_32971 crossref_primary_10_1089_vim_2024_0006 crossref_primary_10_1007_s00251_005_0067_0 crossref_primary_10_12688_f1000research_6116_1 crossref_primary_10_1080_01902148_2017_1412541 crossref_primary_10_1038_ni_1736 crossref_primary_10_1155_2019_1426954 crossref_primary_10_1080_13693780801982762 crossref_primary_10_1155_2018_4765358 crossref_primary_10_1517_13543776_17_4_453 crossref_primary_10_1016_j_imbio_2012_05_014 crossref_primary_10_1101_cshperspect_a028530 crossref_primary_10_1007_s12017_010_8112_z crossref_primary_10_1016_j_intimp_2008_03_022 crossref_primary_10_1016_j_smim_2007_10_012 crossref_primary_10_1007_s00439_020_02180_0 crossref_primary_10_1073_pnas_1816698116 crossref_primary_10_3390_ijms21062069 crossref_primary_10_4049_jimmunol_0901566 crossref_primary_10_4049_jimmunol_1600506 crossref_primary_10_3748_wjg_15_5784 crossref_primary_10_1038_ni_1882 crossref_primary_10_12938_bmfh_2023_027 crossref_primary_10_18632_aging_103101 crossref_primary_10_1080_14653240600845237 crossref_primary_10_1157_13090382 crossref_primary_10_1016_j_pharep_2014_09_007 crossref_primary_10_1038_nrd3794 crossref_primary_10_1089_vim_2019_0178 crossref_primary_10_2147_PTT_S312109 crossref_primary_10_1016_j_cellimm_2019_02_003 crossref_primary_10_1097_01_MIB_0000437616_37000_41 crossref_primary_10_1016_j_chembiol_2013_05_010 crossref_primary_10_1016_j_cyto_2017_08_014 crossref_primary_10_1128_microbiolspec_TBTB2_0018_2016 crossref_primary_10_1155_2012_606459 crossref_primary_10_1007_s00262_006_0171_5 crossref_primary_10_1016_j_taap_2012_11_008 crossref_primary_10_1016_j_cyto_2023_156452 crossref_primary_10_1093_infdis_jiaa766 crossref_primary_10_1128_CVI_00135_12 crossref_primary_10_1111_j_1600_0625_2007_00677_x crossref_primary_10_1126_sciimmunol_aau6571 crossref_primary_10_4049_jimmunol_176_12_7768 crossref_primary_10_1007_s11481_011_9315_2 crossref_primary_10_1016_j_semarthrit_2018_04_004 crossref_primary_10_1084_jem_20070509 crossref_primary_10_3390_ijms23169344 crossref_primary_10_1074_jbc_M117_782284 |
| Cites_doi | 10.1002/eji.1830250133 10.4049/jimmunol.154.10.5071 10.4049/jimmunol.169.10.5673 10.4049/jimmunol.166.12.7563 10.1073/pnas.93.24.14002 10.1046/j.1523-1747.1998.00347.x 10.4049/jimmunol.171.11.6173 10.4049/jimmunol.166.7.4446 10.1046/j.1365-3083.1996.d01-4.x 10.4049/jimmunol.166.9.5448 10.1074/jbc.M207577200 10.4049/jimmunol.146.9.3074 10.1073/pnas.90.13.6115 10.1084/jem.184.2.747 10.1074/jbc.M105927200 10.4049/jimmunol.173.3.1887 10.1016/S0962-8924(00)01856-0 10.1189/jlb.71.1.1 10.1084/jem.187.12.2103 10.1002/eji.200323518 10.4049/jimmunol.154.10.5320 10.1084/jem.183.1.147 10.1002/eji.1830250442 10.1186/1471-2172-3-14 10.1172/JCI0215751 10.4049/jimmunol.168.11.5448 10.4049/jimmunol.170.1.597 10.1038/41131 10.4049/jimmunol.170.4.2153 10.4049/jimmunol.172.5.2827 10.1016/S1074-7613(00)80614-7 10.4049/jimmunol.170.4.2106 10.1016/S0020-7519(03)00032-8 10.4049/jimmunol.167.9.5304 10.1191/135245899678847275 10.4049/jimmunol.157.4.1589 10.4049/jimmunol.149.11.3495 10.4049/jimmunol.167.1.221 10.1002/1529-0131(200110)44:10<2413::AID-ART406>3.0.CO;2-E 10.4049/jimmunol.168.11.5699 10.1016/S1074-7613(00)00070-4 10.1182/blood-2002-12-3854 10.1006/mcne.1998.0725 10.4049/jimmunol.153.1.128 10.4049/jimmunol.163.5.2517 10.1128/IAI.66.10.4994-5000.1998 10.1084/jem.192.1.123 10.4049/jimmunol.154.4.1606 10.1073/pnas.1035999100 10.1002/eji.200324815 10.1007/BF03401888 10.1002/eji.200324343 10.1016/S0140-6736(87)92863-7 10.4049/jimmunol.156.1.5 10.1096/fj.03-1367fje 10.1073/pnas.1332767100 10.1084/jem.189.12.1981 10.1084/jem.20030896 10.1016/0955-2235(92)90016-B 10.1038/nature01355 10.4049/jimmunol.161.5.2223 10.1084/jem.20021769 10.1126/science.8097338 10.1182/blood-2004-02-0584 10.1002/1521-4141(200203)32:3<686::AID-IMMU686>3.0.CO;2-I 10.4049/jimmunol.164.1.64 10.1002/eji.1830260134 10.4049/jimmunol.165.2.628 10.1002/eji.1830260705 10.4049/jimmunol.157.8.3223 10.4049/jimmunol.164.5.2832 10.4049/jimmunol.169.12.7104 10.1038/nri1001 10.1073/pnas.0400983101 10.1038/ni832 10.1128/IAI.70.4.1936-1948.2002 10.1146/annurev.immunol.16.1.495 10.4049/jimmunol.158.8.3593 10.4049/jimmunol.167.2.957 10.1038/378088a0 10.4049/jimmunol.170.9.4432 10.4049/jimmunol.158.11.5507 10.1172/JCI17321 10.4049/jimmunol.165.11.6107 10.1084/jem.170.3.827 10.4049/jimmunol.168.3.1322 |
| ContentType | Journal Article |
| DBID | BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1111/j.0105-2896.2004.00214.x |
| DatabaseName | Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE CrossRef |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1600-065X |
| EndPage | 105 |
| ExternalDocumentID | 15546388 10_1111_j_0105_2896_2004_00214_x IMR214 ark_67375_WNG_04WQ4V4Z_W |
| Genre | reviewArticle Research Support, Non-U.S. Gov't Journal Article Review |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 29I 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8F7 8UM 930 A01 A03 AAESR AAEVG AAHHS AAKAS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACFBH ACGFO ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZCM ADZMN ADZOD AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFRAH AFZJQ AHBTC AHEFC AI. AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOETA ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EAD EAP EAS EBB EBC EBD EBS EBX EJD EMB EMK EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IH2 IHE IX1 J0M K48 KBYEO L7B LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MVM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OBC OBS OEB OIG OVD P2P P2W P2X P2Z P4B P4D PALCI Q.N Q11 QB0 R.K RIWAO RJQFR ROL RWI RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 V8K VH1 W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR X7N XG1 XV2 YFH YOC YUY YYP ZGI ZXP ZZTAW ~IA ~KM ~WT AAHQN AAIPD AAMNL AANHP AAYCA ACRPL ACUHS ACYXJ ADNMO AFWVQ ALVPJ AAYXX AETEA AEYWJ AGHNM AGQPQ AGYGG CITATION CGR CUY CVF ECM EIF NPM PKN 7X8 AAMMB AEFGJ AGXDD AIDQK AIDYY |
| ID | FETCH-LOGICAL-c4684-2b3bcecf1de1010cd5889289e56cc610e98f3b9e95c6bcfd747b3c75fada4cd83 |
| IEDL.DBID | DR2 |
| ISSN | 0105-2896 |
| IngestDate | Fri Jul 11 08:36:26 EDT 2025 Wed Feb 19 01:37:43 EST 2025 Tue Jul 01 03:22:53 EDT 2025 Thu Apr 24 23:04:53 EDT 2025 Wed Jan 22 16:44:18 EST 2025 Wed Oct 30 09:48:49 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4684-2b3bcecf1de1010cd5889289e56cc610e98f3b9e95c6bcfd747b3c75fada4cd83 |
| Notes | istex:584274C0449686A50B7D781C79D345268096DD08 ark:/67375/WNG-04WQ4V4Z-W ArticleID:IMR214 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 15546388 |
| PQID | 67079636 |
| PQPubID | 23479 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_67079636 pubmed_primary_15546388 crossref_citationtrail_10_1111_j_0105_2896_2004_00214_x crossref_primary_10_1111_j_0105_2896_2004_00214_x wiley_primary_10_1111_j_0105_2896_2004_00214_x_IMR214 istex_primary_ark_67375_WNG_04WQ4V4Z_W |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | December 2004 |
| PublicationDateYYYYMMDD | 2004-12-01 |
| PublicationDate_xml | – month: 12 year: 2004 text: December 2004 |
| PublicationDecade | 2000 |
| PublicationPlace | Oxford, UK; Malden, USA |
| PublicationPlace_xml | – name: Oxford, UK; Malden, USA – name: England |
| PublicationTitle | Immunological reviews |
| PublicationTitleAlternate | Immunol Rev |
| PublicationYear | 2004 |
| Publisher | Munksgaard International Publishers |
| Publisher_xml | – name: Munksgaard International Publishers |
| References | Lehmann J, Bellmann S, Werner C, Schroder R, Schutze N, Alber G. IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J Immunol 2001;167: 5304-5315. Yap G, Pesin M, Sher A. Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J Immunol 2000;165: 628-631. Stober D, Schirmbeck R, Reimann J. IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells. J Immunol 2001;167: 957-965. Zhang G, et al. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol 2003;170: 2153-2160. Wiekowski MT, et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J Immunol 2001;166: 7563-7570. Medzhitov R, Preston-Hurlburt P, Janeway CAJ. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388: 394-397.DOI: 10.1038/41131 Fieschi C, et al. Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications. J Exp Med 2003;197: 527-535.DOI: 10.1084/jem.20021769 Aggarwal S, Ghilardi N, Xie MH, De Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003;278: 1910-1914.DOI: 10.1074/jbc.M207577200 Belladonna ML, et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol 2002;168: 5448-5454. Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA 2003;100: 5986-5990.DOI: 10.1073/pnas.1035999100 Panitch HS, Hirsch RL, Haley AS, Johnson KP. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1987;1: 893-895.DOI: 10.1016/S0140-6736(87)92863-7 Dubois B, et al. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. J Immunol 1998;161: 2223-2231. Murphy CA, et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 2003;198: 1951-1957.DOI: 10.1084/jem.20030896 Cleary AM, Tu W, Giffon T, Dewaal-Malefyt R, Gutierrez K, Lewis DB. Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency. J Immunol 2003;170: 597-603. Ma X, et al. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med 1996;183: 147-157.DOI: 10.1084/jem.183.1.147 Wesa A, Galy A. Increased production of pro-inflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL-1 and CD40 ligand. BMC Immunol 2002;3: 14.DOI: 10.1186/1471-2172-3-14 Gazzinelli RT, Hieny S, Wynn TA, Wolf S, Sher A. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci USA 1993;90: 6115-6119. Shu U, et al. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur J Immunol 1995;25: 1125-1128. Gately MK, et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 1998;16: 495-521.DOI: 10.1146/annurev.immunol.16.1.495 Renno T, et al. Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAE. Mol Cell Neurosci 1998;12: 376-389.DOI: 10.1006/mcne.1998.0725 Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003;3: 133-146.DOI: 10.1038/nri1001 Hochrein H, Shortman K, Vremec D, Scott B, Hertzog P, O'Keeffe M. Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J Immunol 2001;166: 5448-5455. Vartanian T, Li Y, Zhao M, Stefansson K. Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol Med 1995;1: 732-743. Willenborg DO, Fordham S, Bernard CC, Cowden WB, Ramshaw IA. IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol 1996;157: 3223-3227. Presky DH, et al. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA 1996;93: 14002-14007.DOI: 10.1073/pnas.93.24.14002 Macatonia SE, et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 1995;154: 5071-5079. Decken K, et al. Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect Immun 1998;66: 4994-5000. Ziolkowska M, et al. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol 2000;164: 2832-2838. Smits HH, et al. Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur J Immunol 2004;34: 1371-1380.DOI: 10.1002/eji.200324815 Perussia B, et al. Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells. J Immunol 1992;149: 3495-3502. Ohteki T, et al. Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J Exp Med 1999;189: 1981-1986.DOI: 10.1084/jem.189.12.1981 Wolf SF, et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 1991;146: 3074-3081. Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O'Garra A, Murphy KM. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260: 547-549. Rodriguez-Sosa M, Satoskar AR, David JR, Terrazas LI. Altered T helper responses in CD40 and interleukin-12 deficient mice reveal a critical role for Th1 responses in eliminating the helminth parasite Taenia crassiceps. Int J Parasitol 2003;33: 703-711.DOI: 10.1016/S0020-7519(03)00032-8 Nurieva RI, Treuting P, Duong J, Flavell RA, Dong C. Inducible costimulator is essential for collagen-induced arthritis. J Clin Invest 2003;111: 701-706. Fieschi C, et al. A novel form of complete IL-12/IL-23 receptor beta1-deficiency with cell surface-expressed non-functional receptors. Blood 2004. Okamura H, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995;378: 88-91.DOI: 10.1038/378088a0 Elkins KL, Cooper A, Colombini SM, Cowley SC, Kieffer TL. In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70. Infect Immun 2002;70: 1936-1948.DOI: 10.1128/IAI.70.4.1936-1948.2002 Lieberman LA, et al. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol 2004;173: 1887-1893. Ghilardi N, Kljavin N, Chen Q, Lucas S, Gurney AL, De Sauvage FJ. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 2004;172: 2827-2833. Aggarwal S, Gurney A. IL-17: prototype member of an emerging cytokine family. J Leukoc Biol 2002;71: 1-8. Wu CY, et al. Distinct lineages of T(H) 1 cells have differential capacities for memory cell generation in vivo. Nat Immunol 2002;3: 852-858.DOI: 10.1038/ni832 Jones BM. Effect of 12 neutralizing anti-cytokine antibodies on in vitro activation of B-cells. Interleukin-12 is required by B1a but not B2 cells. Scand J Immunol 1996;43: 64-72.DOI: 10.1046/j.1365-3083.1996.d01-4.x Ferber I, et al. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 1996;156: 5-7. Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003;171: 6173-6177. Armant M, Armitage R, Boiani N, Delespesse G, Sarfati M. Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement: involvement in interleukin-2-induced interleukin-12 and interferon-gamma production. Eur J Immunol 1996;26: 1430-1434. Happel KI, et al. Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J Immunol 2003;170: 4432-4436. Fukao T, Matsuda S, Koyasu S. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. J Immunol 2000;164: 64-71. Fukao T, Frucht DM, Yap G, Gadina M, O'Shea JJ, Koyasu S. Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J Immunol 2001;166: 4446-4455. Chu CQ, Wittmer S, Dalton DK. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J Exp Med 2000;192: 123-128. Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996;184: 747-752. Matusevicius D, et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 1999;5: 101-104.DOI: 10.1191/135245899678847275 Jelinek D, Braaten J. Role of IL-12 in human B lymphocyte proliferation and differentiation. J 1997; 158 1987; 1 2002; 110 1996; 184 1996; 183 1999; 163 1995; 378 2001; 44 1998; 111 2003; 278 2003; 111 2003; 198 2003; 197 1998; 16 1997; 388 1991; 146 1995; 25 2000; 13 2000; 10 2004; 173 2004; 34 2004; 172 2003; 3 2000; 164 2000; 165 1996; 26 1998; 12 1998; 161 1992; 4 2001; 166 2004; 101 2001; 167 1995; 15 1994; 153 2002; 32 1993; 260 1992; 149 1996; 93 2002; 3 2003; 171 2003; 170 1993; 90 2004 1999; 189 1995; 154 1995; 1 1999; 5 1998; 66 2003; 33 2000; 192 2001; 276 2004; 18 2002; 168 2002; 169 1989; 170 2002; 70 2002; 71 1998; 187 2003; 421 2003; 102 1996; 157 1996; 156 2003; 100 1996; 43 1998; 9 e_1_2_7_3_2 e_1_2_7_9_2 e_1_2_7_7_2 e_1_2_7_19_2 Grohmann U (e_1_2_7_36_2) 1997; 158 e_1_2_7_17_2 e_1_2_7_83_2 e_1_2_7_15_2 e_1_2_7_60_2 e_1_2_7_81_2 e_1_2_7_13_2 e_1_2_7_41_2 e_1_2_7_62_2 e_1_2_7_87_2 e_1_2_7_43_2 e_1_2_7_64_2 e_1_2_7_85_2 e_1_2_7_45_2 e_1_2_7_66_2 e_1_2_7_47_2 e_1_2_7_68_2 e_1_2_7_26_2 e_1_2_7_49_2 e_1_2_7_28_2 Willenborg DO (e_1_2_7_73_2) 1996; 157 Perussia B (e_1_2_7_33_2) 1992; 149 e_1_2_7_71_2 e_1_2_7_50_2 e_1_2_7_75_2 e_1_2_7_23_2 e_1_2_7_31_2 e_1_2_7_54_2 e_1_2_7_21_2 e_1_2_7_56_2 e_1_2_7_79_2 e_1_2_7_35_2 e_1_2_7_58_2 e_1_2_7_77_2 e_1_2_7_37_2 e_1_2_7_39_2 Jelinek D (e_1_2_7_53_2) 1995; 154 e_1_2_7_4_2 e_1_2_7_2_2 Chua AO (e_1_2_7_11_2) 1994; 153 e_1_2_7_8_2 e_1_2_7_6_2 e_1_2_7_18_2 e_1_2_7_82_2 Dubois B (e_1_2_7_52_2) 1998; 161 e_1_2_7_61_2 e_1_2_7_80_2 e_1_2_7_14_2 e_1_2_7_40_2 e_1_2_7_63_2 e_1_2_7_86_2 e_1_2_7_12_2 e_1_2_7_42_2 e_1_2_7_65_2 e_1_2_7_84_2 Bianchi R (e_1_2_7_25_2) 1999; 163 e_1_2_7_10_2 e_1_2_7_44_2 e_1_2_7_67_2 e_1_2_7_46_2 e_1_2_7_69_2 e_1_2_7_88_2 e_1_2_7_48_2 e_1_2_7_27_2 e_1_2_7_29_2 Macatonia SE (e_1_2_7_16_2) 1995; 154 e_1_2_7_72_2 e_1_2_7_70_2 e_1_2_7_24_2 e_1_2_7_30_2 e_1_2_7_51_2 e_1_2_7_76_2 e_1_2_7_22_2 e_1_2_7_32_2 e_1_2_7_74_2 Macatonia SE (e_1_2_7_5_2) 1995; 15 e_1_2_7_20_2 e_1_2_7_34_2 e_1_2_7_55_2 e_1_2_7_57_2 e_1_2_7_78_2 e_1_2_7_38_2 e_1_2_7_59_2 |
| References_xml | – reference: Happel KI, et al. Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J Immunol 2003;170: 4432-4436. – reference: Pirhonen J, Matikainen S, Julkunen I. Regulation of virus-induced IL-12 and IL-23 expression in human macrophages. J Immunol 2002;169: 5673-5678. – reference: Aggarwal S, Ghilardi N, Xie MH, De Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003;278: 1910-1914.DOI: 10.1074/jbc.M207577200 – reference: Gran B, et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J Immunol 2002;169: 7104-7110. – reference: Trinchieri G, et al. Natural killer cell stimulatory factor (NKSF) or interleukin-12 is a key regulator of immune response and inflammation. Prog Growth Factor Res 1992;4: 355-368. – reference: Wolf SF, et al. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol 1991;146: 3074-3081. – reference: Decken K, et al. Interleukin-12 is essential for a protective Th1 response in mice infected with Cryptococcus neoformans. Infect Immun 1998;66: 4994-5000. – reference: Sheibanie AF, Tadmori I, Jing H, Vassiliou E, Ganea D. Prostaglandin E2 induces IL-23 production in bone marrow-derived dendritic cells. FASEB J 2004;18: 1318-1320. – reference: Cua DJ, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003;421: 744-748. – reference: Kobayashi M, et al. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989;170: 827-845.DOI: 10.1084/jem.170.3.827 – reference: Panitch HS, Hirsch RL, Haley AS, Johnson KP. Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 1987;1: 893-895.DOI: 10.1016/S0140-6736(87)92863-7 – reference: Grohmann U, et al. Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma. J Immunol 2001;167: 221-227. – reference: Parham C, et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J Immunol 2002;168: 5699-5708. – reference: Ghilardi N, Kljavin N, Chen Q, Lucas S, Gurney AL, De Sauvage FJ. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol 2004;172: 2827-2833. – reference: Lehmann J, Bellmann S, Werner C, Schroder R, Schutze N, Alber G. IL-12p40-dependent agonistic effects on the development of protective innate and adaptive immunity against Salmonella enteritidis. J Immunol 2001;167: 5304-5315. – reference: Munder M, Mallo M, Eichmann K, Modolell M. Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: a novel pathway of autocrine macrophage activation. J Exp Med 1998;187: 2103-2108.DOI: 10.1084/jem.187.12.2103 – reference: Fieschi C, et al. Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications. J Exp Med 2003;197: 527-535.DOI: 10.1084/jem.20021769 – reference: Fieschi C, et al. A novel form of complete IL-12/IL-23 receptor beta1-deficiency with cell surface-expressed non-functional receptors. Blood 2004. – reference: Zhang G, et al. Induction of experimental autoimmune encephalomyelitis in IL-12 receptor-beta 2-deficient mice: IL-12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system. J Immunol 2003;170: 2153-2160. – reference: Guedez YB, et al.Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain. Arthritis Rheum 2001;44: 2413-2424.DOI: 10.1002/1529-0131(200110)44:10<2413::AID-ART406>3.0.CO;2-E – reference: Bianchi R, Grohmann U, Vacca C, Belladonna ML, Fioretti MC, Puccetti P. Autocrine IL-12 is involved in dendritic cell modulation via CD40 ligation. J Immunol 1999;163: 2517-2521. – reference: Grohmann U, et al. A tumor-associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL-12 can prevent or revert the anergic state. J Immunol 1997;158: 3593-3602. – reference: Jones BM. Effect of 12 neutralizing anti-cytokine antibodies on in vitro activation of B-cells. Interleukin-12 is required by B1a but not B2 cells. Scand J Immunol 1996;43: 64-72.DOI: 10.1046/j.1365-3083.1996.d01-4.x – reference: O'Garra A, Arai N. The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol 2000;10: 542-550.DOI: 10.1016/S0962-8924(00)01856-0 – reference: Gately MK, et al. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 1998;16: 495-521.DOI: 10.1146/annurev.immunol.16.1.495 – reference: Cleary AM, Tu W, Giffon T, Dewaal-Malefyt R, Gutierrez K, Lewis DB. Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency. J Immunol 2003;170: 597-603. – reference: Ferber I, et al. Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol 1996;156: 5-7. – reference: Yap G, Pesin M, Sher A. Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J Immunol 2000;165: 628-631. – reference: Vartanian T, Li Y, Zhao M, Stefansson K. Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis. Mol Med 1995;1: 732-743. – reference: Bianchi R, et al. IL-12 is both required and sufficient for initiating T cell reactivity to a class I-restricted tumor peptide (P815AB) following transfer of P815AB-pulsed dendritic cells. J Immunol 1996;157: 1589-1597. – reference: Becher B, Durell BG, Noelle RJ. Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. J Clin Invest 2002;110: 493-497. – reference: Hoeve M, De Boer T, Langenberg DM, Sanal O, Verreck FA, Ottenhoff TH. IL-12 receptor deficiency revisited: IL-23-mediated signaling is also impaired in human genetic IL-12 receptor beta1 deficiency. Eur J Immunol 2003;33: 3393-3397.DOI: 10.1002/eji.200324343 – reference: Oppmann B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000;13: 715-725.DOI: 10.1016/S1074-7613(00)00070-4 – reference: Vogel LA, Lester TL, Van Cleave VH, Metzger DW. Inhibition of murine B1 lymphocytes by interleukin-12. Eur J Immunol 1996;26: 219-223. – reference: Lieberman LA, et al. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol 2004;173: 1887-1893. – reference: Nakae S, Nambu A, Sudo K, Iwakura Y. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J Immunol 2003;171: 6173-6177. – reference: Lugo-Villarino G, Maldonado-Lopez R, Possemato R, Penaranda C, Glimcher LH. T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci USA 2003;100: 7749-7754.DOI: 10.1073/pnas.1332767100 – reference: Re F, Strominger JL. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 2001;276: 37692-37699.DOI: 10.1074/jbc.M105927200 – reference: Okamura H, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995;378: 88-91.DOI: 10.1038/378088a0 – reference: Gazzinelli RT, Hieny S, Wynn TA, Wolf S, Sher A. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc Natl Acad Sci USA 1993;90: 6115-6119. – reference: Macatonia SE, et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 1995;154: 5071-5079. – reference: Dubois B, et al. Critical role of IL-12 in dendritic cell-induced differentiation of naive B lymphocytes. J Immunol 1998;161: 2223-2231. – reference: Willenborg DO, Fordham S, Bernard CC, Cowden WB, Ramshaw IA. IFN-gamma plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. J Immunol 1996;157: 3223-3227. – reference: Rodriguez-Sosa M, Satoskar AR, David JR, Terrazas LI. Altered T helper responses in CD40 and interleukin-12 deficient mice reveal a critical role for Th1 responses in eliminating the helminth parasite Taenia crassiceps. Int J Parasitol 2003;33: 703-711.DOI: 10.1016/S0020-7519(03)00032-8 – reference: Wu CY, et al. Distinct lineages of T(H) 1 cells have differential capacities for memory cell generation in vivo. Nat Immunol 2002;3: 852-858.DOI: 10.1038/ni832 – reference: Jelinek D, Braaten J. Role of IL-12 in human B lymphocyte proliferation and differentiation. J Immunol 1995;154: 1606-1613. – reference: Nikolic T, Dingjan GM, Leenen PJ, Hendriks RW. A subfraction of B220(+) cells in murine bone marrow and spleen does not belong to the B cell lineage but has dendritic cell characteristics. Eur J Immunol 2002;32: 686-692.DOI: 10.1002/1521-4141(200203)32:3<686::AID-IMMU686>3.0.CO;2-I – reference: Renno T, et al. Interferon-gamma in progression to chronic demyelination and neurological deficit following acute EAE. Mol Cell Neurosci 1998;12: 376-389.DOI: 10.1006/mcne.1998.0725 – reference: Chua AO, et al. Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol 1994;153: 128-136. – reference: Smits HH, et al. Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur J Immunol 2004;34: 1371-1380.DOI: 10.1002/eji.200324815 – reference: Fukao T, Matsuda S, Koyasu S. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. J Immunol 2000;164: 64-71. – reference: Gillessen S, et al. Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. Eur J Immunol 1995;25: 200-206. – reference: Armant M, Armitage R, Boiani N, Delespesse G, Sarfati M. Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement: involvement in interleukin-2-induced interleukin-12 and interferon-gamma production. Eur J Immunol 1996;26: 1430-1434. – reference: Perussia B, et al. Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells. J Immunol 1992;149: 3495-3502. – reference: Scharton-Kersten T, Afonso LC, Wysocka M, Trinchieri G, Scott P. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol 1995;154: 5320-5330. – reference: Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003;3: 133-146.DOI: 10.1038/nri1001 – reference: Infante-Duarte C, Horton HF, Byrne MC, Kamradt T. Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol 2000;165: 6107-6115. – reference: Medzhitov R, Preston-Hurlburt P, Janeway CAJ. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388: 394-397.DOI: 10.1038/41131 – reference: Grohmann U, et al. IL-12 acts directly on DC to promote nuclear localization of NF-kappaB and primes DC for IL-12 production. Immunity 1998;9: 315-323.DOI: 10.1016/S1074-7613(00)80614-7 – reference: Vermeire K, Heremans H, Vandeputte M, Huang S, Billiau A, Matthys P. Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice. J Immunol 1997;158: 5507-5513. – reference: Teunissen MB, Koomen CW, De Waal Malefyt R, Wierenga EA, Bos JD. Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol 1998;111: 645-649.DOI: 10.1046/j.1523-1747.1998.00347.x – reference: Murphy CA, et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 2003;198: 1951-1957.DOI: 10.1084/jem.20030896 – reference: Wesa A, Galy A. Increased production of pro-inflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL-1 and CD40 ligand. BMC Immunol 2002;3: 14.DOI: 10.1186/1471-2172-3-14 – reference: Macatonia SE, et al. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. J Immunol 1995;15: 5071-5079. – reference: Elkins KL, Cooper A, Colombini SM, Cowley SC, Kieffer TL. In vivo clearance of an intracellular bacterium, Francisella tularensis LVS, is dependent on the p40 subunit of interleukin-12 (IL-12) but not on IL-12 p70. Infect Immun 2002;70: 1936-1948.DOI: 10.1128/IAI.70.4.1936-1948.2002 – reference: Ziolkowska M, et al. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J Immunol 2000;164: 2832-2838. – reference: Hochrein H, Shortman K, Vremec D, Scott B, Hertzog P, O'Keeffe M. Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets. J Immunol 2001;166: 5448-5455. – reference: Wiekowski MT, et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J Immunol 2001;166: 7563-7570. – reference: Belladonna ML, et al. IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells. J Immunol 2002;168: 5448-5454. – reference: Krajina T, Leithauser F, Moller P, Trobonjaca Z, Reimann J. Colonic lamina propria dendritic cells in mice with CD4+ T cell-induced colitis. Eur J Immunol 2003;33: 1073-1083.DOI: 10.1002/eji.200323518 – reference: Stober D, Schirmbeck R, Reimann J. IL-12/IL-18-dependent IFN-gamma release by murine dendritic cells. J Immunol 2001;167: 957-965. – reference: Nurieva RI, Treuting P, Duong J, Flavell RA, Dong C. Inducible costimulator is essential for collagen-induced arthritis. J Clin Invest 2003;111: 701-706. – reference: Shu U, et al. Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur J Immunol 1995;25: 1125-1128. – reference: Verreck FA, et al. Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco) bacteria. Proc Natl Acad Sci USA 2004;101: 4560-4565.DOI: 10.1073/pnas.0400983101 – reference: Chu CQ, Wittmer S, Dalton DK. Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma-deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis. J Exp Med 2000;192: 123-128. – reference: Hsieh CS, Macatonia SE, Tripp CS, Wolf SF, O'Garra A, Murphy KM. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260: 547-549. – reference: Jefford M, et al. Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli. Blood 2003;102: 1753-1763. – reference: Ohteki T, et al. Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells. J Exp Med 1999;189: 1981-1986.DOI: 10.1084/jem.189.12.1981 – reference: Aggarwal S, Gurney A. IL-17: prototype member of an emerging cytokine family. J Leukoc Biol 2002;71: 1-8. – reference: Matusevicius D, et al. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult Scler 1999;5: 101-104.DOI: 10.1191/135245899678847275 – reference: Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996;184: 747-752. – reference: Nakae S, Saijo S, Horai R, Sudo K, Mori S, Iwakura Y. IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc Natl Acad Sci USA 2003;100: 5986-5990.DOI: 10.1073/pnas.1035999100 – reference: Ma X, et al. The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells. J Exp Med 1996;183: 147-157.DOI: 10.1084/jem.183.1.147 – reference: Ferretti S, Bonneau O, Dubois GR, Jones CE, Trifilieff A. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger. J Immunol 2003;170: 2106-2112. – reference: Fukao T, Frucht DM, Yap G, Gadina M, O'Shea JJ, Koyasu S. Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses. J Immunol 2001;166: 4446-4455. – reference: Cooper AM, Kipnis A, Turner J, Magram J, Ferrante J, Orme IM. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol 2002;168: 1322-1327. – reference: Presky DH, et al. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci USA 1996;93: 14002-14007.DOI: 10.1073/pnas.93.24.14002 – volume: 26 start-page: 1430 year: 1996 end-page: 1434 article-title: Functional CD40 ligand expression on T lymphocytes in the absence of T cell receptor engagement: involvement in interleukin‐2‐induced interleukin‐12 and interferon‐gamma production publication-title: Eur J Immunol – volume: 93 start-page: 14002 year: 1996 end-page: 14007 article-title: A functional interleukin 12 receptor complex is composed of two beta‐type cytokine receptor subunits publication-title: Proc Natl Acad Sci USA – volume: 154 start-page: 5071 year: 1995 end-page: 5079 article-title: Dendritic cells produce IL‐12 and direct the development of Th1 cells from naive CD4 T cells publication-title: J Immunol – volume: 192 start-page: 123 year: 2000 end-page: 128 article-title: Failure to suppress the expansion of the activated CD4 T cell population in interferon gamma‐deficient mice leads to exacerbation of experimental autoimmune encephalomyelitis publication-title: J Exp Med – volume: 166 start-page: 4446 year: 2001 end-page: 4455 article-title: Inducible expression of Stat4 in dendritic cells and macrophages and its critical role in innate and adaptive immune responses publication-title: J Immunol – volume: 172 start-page: 2827 year: 2004 end-page: 2833 article-title: Compromised humoral and delayed‐type hypersensitivity responses in IL‐23‐deficient mice publication-title: J Immunol – volume: 100 start-page: 7749 year: 2003 end-page: 7754 article-title: T‐bet is required for optimal production of IFN‐gamma and antigen‐specific T cell activation by dendritic cells publication-title: Proc Natl Acad Sci USA – volume: 170 start-page: 4432 year: 2003 end-page: 4436 article-title: Cutting edge: roles of Toll‐like receptor 4 and IL‐23 in IL‐17 expression in response to Klebsiella pneumoniae infection publication-title: J Immunol – volume: 90 start-page: 6115 year: 1993 end-page: 6119 article-title: Interleukin 12 is required for the T‐lymphocyte‐independent induction of interferon gamma by an intracellular parasite and induces resistance in T‐cell‐deficient hosts publication-title: Proc Natl Acad Sci USA – volume: 164 start-page: 2832 year: 2000 end-page: 2838 article-title: High levels of IL‐17 in rheumatoid arthritis patients: IL‐15 triggers in vitro IL‐17 production via cyclosporin A‐sensitive mechanism publication-title: J Immunol – volume: 16 start-page: 495 year: 1998 end-page: 521 article-title: The interleukin‐12/interleukin‐12‐receptor system: role in normal and pathologic immune responses publication-title: Annu Rev Immunol – volume: 170 start-page: 597 year: 2003 end-page: 603 article-title: Impaired accumulation and function of memory CD4 T cells in human IL‐12 receptor beta 1 deficiency publication-title: J Immunol – volume: 153 start-page: 128 year: 1994 end-page: 136 article-title: Expression cloning of a human IL‐12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130 publication-title: J Immunol – volume: 168 start-page: 1322 year: 2002 end-page: 1327 article-title: Mice lacking bioactive IL‐12 can generate protective, antigen‐specific cellular responses to mycobacterial infection only if the IL‐12 p40 subunit is present publication-title: J Immunol – volume: 32 start-page: 686 year: 2002 end-page: 692 article-title: A subfraction of B220(+) cells in murine bone marrow and spleen does not belong to the B cell lineage but has dendritic cell characteristics publication-title: Eur J Immunol – volume: 15 start-page: 5071 year: 1995 end-page: 5079 article-title: Dendritic cells produce IL‐12 and direct the development of Th1 cells from naive CD4 T cells publication-title: J Immunol – volume: 66 start-page: 4994 year: 1998 end-page: 5000 article-title: Interleukin‐12 is essential for a protective Th1 response in mice infected with publication-title: Infect Immun – volume: 187 start-page: 2103 year: 1998 end-page: 2108 article-title: Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)‐12 and IL‐18: a novel pathway of autocrine macrophage activation publication-title: J Exp Med – year: 2004 article-title: A novel form of complete IL‐12/IL‐23 receptor beta1‐deficiency with cell surface‐expressed non‐functional receptors publication-title: Blood – volume: 44 start-page: 2413 year: 2001 end-page: 2424 article-title: Genetic ablation of interferon‐gamma up‐regulates interleukin‐1beta expression and enables the elicitation of collagen‐induced arthritis in a nonsusceptible mouse strain publication-title: Arthritis Rheum – volume: 146 start-page: 3074 year: 1991 end-page: 3081 article-title: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells publication-title: J Immunol – volume: 167 start-page: 957 year: 2001 end-page: 965 article-title: IL‐12/IL‐18‐dependent IFN‐gamma release by murine dendritic cells publication-title: J Immunol – volume: 276 start-page: 37692 year: 2001 end-page: 37699 article-title: Toll‐like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells publication-title: J Biol Chem – volume: 13 start-page: 715 year: 2000 end-page: 725 article-title: Novel p19 protein engages IL‐12p40 to form a cytokine, IL‐23, with biological activities similar as well as distinct from IL‐12 publication-title: Immunity – volume: 33 start-page: 703 year: 2003 end-page: 711 article-title: Altered T helper responses in CD40 and interleukin‐12 deficient mice reveal a critical role for Th1 responses in eliminating the helminth parasite publication-title: Int J Parasitol – volume: 157 start-page: 1589 year: 1996 end-page: 1597 article-title: IL‐12 is both required and sufficient for initiating T cell reactivity to a class I‐restricted tumor peptide (P815AB) following transfer of P815AB‐pulsed dendritic cells publication-title: J Immunol – volume: 102 start-page: 1753 year: 2003 end-page: 1763 article-title: Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli publication-title: Blood – volume: 198 start-page: 1951 year: 2003 end-page: 1957 article-title: Divergent pro‐ and antiinflammatory roles for IL‐23 and IL‐12 in joint autoimmune inflammation publication-title: J Exp Med – volume: 166 start-page: 5448 year: 2001 end-page: 5455 article-title: Differential production of IL‐12, IFN‐alpha, and IFN‐gamma by mouse dendritic cell subsets publication-title: J Immunol – volume: 170 start-page: 2106 year: 2003 end-page: 2112 article-title: IL‐17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide‐induced airway neutrophilia: IL‐15 as a possible trigger publication-title: J Immunol – volume: 3 start-page: 133 year: 2003 end-page: 146 article-title: Interleukin‐12 and the regulation of innate resistance and adaptive immunity publication-title: Nat Rev Immunol – volume: 70 start-page: 1936 year: 2002 end-page: 1948 article-title: In vivo clearance of an intracellular bacterium, LVS, is dependent on the p40 subunit of interleukin‐12 (IL‐12) but not on IL‐12 p70 publication-title: Infect Immun – volume: 183 start-page: 147 year: 1996 end-page: 157 article-title: The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells publication-title: J Exp Med – volume: 169 start-page: 5673 year: 2002 end-page: 5678 article-title: Regulation of virus‐induced IL‐12 and IL‐23 expression in human macrophages publication-title: J Immunol – volume: 171 start-page: 6173 year: 2003 end-page: 6177 article-title: Suppression of immune induction of collagen‐induced arthritis in IL‐17‐deficient mice publication-title: J Immunol – volume: 388 start-page: 394 year: 1997 end-page: 397 article-title: A human homologue of the Toll protein signals activation of adaptive immunity publication-title: Nature – volume: 100 start-page: 5986 year: 2003 end-page: 5990 article-title: IL‐17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL‐1 receptor antagonist publication-title: Proc Natl Acad Sci USA – volume: 71 start-page: 1 year: 2002 end-page: 8 article-title: IL‐17: prototype member of an emerging cytokine family publication-title: J Leukoc Biol – volume: 157 start-page: 3223 year: 1996 end-page: 3227 article-title: IFN‐gamma plays a critical down‐regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein‐induced autoimmune encephalomyelitis publication-title: J Immunol – volume: 170 start-page: 2153 year: 2003 end-page: 2160 article-title: Induction of experimental autoimmune encephalomyelitis in IL‐12 receptor‐beta 2‐deficient mice: IL‐12 responsiveness is not required in the pathogenesis of inflammatory demyelination in the central nervous system publication-title: J Immunol – volume: 184 start-page: 747 year: 1996 end-page: 752 article-title: Ligation of CD40 on dendritic cells triggers production of high levels of interleukin‐12 and enhances T cell stimulatory capacity: T–T help via APC activation publication-title: J Exp Med – volume: 25 start-page: 200 year: 1995 end-page: 206 article-title: Mouse interleukin‐12 (IL‐12) p40 homodimer: a potent IL‐12 antagonist publication-title: Eur J Immunol – volume: 43 start-page: 64 year: 1996 end-page: 72 article-title: Effect of 12 neutralizing anti‐cytokine antibodies on in vitro activation of B‐cells. Interleukin‐12 is required by B1a but not B2 cells publication-title: Scand J Immunol – volume: 3 start-page: 14 year: 2002 article-title: Increased production of pro‐inflammatory cytokines and enhanced T cell responses after activation of human dendritic cells with IL‐1 and CD40 ligand publication-title: BMC Immunol – volume: 165 start-page: 628 year: 2000 end-page: 631 article-title: Cutting edge: IL‐12 is required for the maintenance of IFN‐gamma production in T cells mediating chronic resistance to the intracellular pathogen, publication-title: J Immunol – volume: 26 start-page: 219 year: 1996 end-page: 223 article-title: Inhibition of murine B1 lymphocytes by interleukin‐12 publication-title: Eur J Immunol – volume: 110 start-page: 493 year: 2002 end-page: 497 article-title: Experimental autoimmune encephalitis and inflammation in the absence of interleukin‐12 publication-title: J Clin Invest – volume: 421 start-page: 744 year: 2003 end-page: 748 article-title: Interleukin‐23 rather than interleukin‐12 is the critical cytokine for autoimmune inflammation of the brain publication-title: Nature – volume: 164 start-page: 64 year: 2000 end-page: 71 article-title: Synergistic effects of IL‐4 and IL‐18 on IL‐12‐dependent IFN‐gamma production by dendritic cells publication-title: J Immunol – volume: 10 start-page: 542 year: 2000 end-page: 550 article-title: The molecular basis of T helper 1 and T helper 2 cell differentiation publication-title: Trends Cell Biol – volume: 5 start-page: 101 year: 1999 end-page: 104 article-title: Interleukin‐17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis publication-title: Mult Scler – volume: 111 start-page: 701 year: 2003 end-page: 706 article-title: Inducible costimulator is essential for collagen‐induced arthritis publication-title: J Clin Invest – volume: 111 start-page: 645 year: 1998 end-page: 649 article-title: Interleukin‐17 and interferon‐gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes publication-title: J Invest Dermatol – volume: 167 start-page: 221 year: 2001 end-page: 227 article-title: Positive regulatory role of IL‐12 in macrophages and modulation by IFN‐gamma publication-title: J Immunol – volume: 34 start-page: 1371 year: 2004 end-page: 1380 article-title: Commensal Gram‐negative bacteria prime human dendritic cells for enhanced IL‐23 and IL‐27 expression and enhanced Th1 development publication-title: Eur J Immunol – volume: 154 start-page: 5320 year: 1995 end-page: 5330 article-title: IL‐12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis publication-title: J Immunol – volume: 3 start-page: 852 year: 2002 end-page: 858 article-title: Distinct lineages of T(H) 1 cells have differential capacities for memory cell generation in vivo publication-title: Nat Immunol – volume: 149 start-page: 3495 year: 1992 end-page: 3502 article-title: Natural killer (NK) cell stimulatory factor or IL‐12 has differential effects on the proliferation of TCR‐alpha beta , TCR‐gamma delta T lymphocytes, and NK cells publication-title: J Immunol – volume: 173 start-page: 1887 year: 2004 end-page: 1893 article-title: IL‐23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL‐12 publication-title: J Immunol – volume: 163 start-page: 2517 year: 1999 end-page: 2521 article-title: Autocrine IL‐12 is involved in dendritic cell modulation via CD40 ligation publication-title: J Immunol – volume: 12 start-page: 376 year: 1998 end-page: 389 article-title: Interferon‐gamma in progression to chronic demyelination and neurological deficit following acute EAE publication-title: Mol Cell Neurosci – volume: 168 start-page: 5699 year: 2002 end-page: 5708 article-title: A receptor for the heterodimeric cytokine IL‐23 is composed of IL‐12Rbeta1 and a novel cytokine receptor subunit, IL‐23R publication-title: J Immunol – volume: 158 start-page: 5507 year: 1997 end-page: 5513 article-title: Accelerated collagen‐induced arthritis in IFN‐gamma receptor‐deficient mice publication-title: J Immunol – volume: 1 start-page: 732 year: 1995 end-page: 743 article-title: Interferon‐gamma‐induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis publication-title: Mol Med – volume: 165 start-page: 6107 year: 2000 end-page: 6115 article-title: Microbial lipopeptides induce the production of IL‐17 in Th cells publication-title: J Immunol – volume: 170 start-page: 827 year: 1989 end-page: 845 article-title: Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes publication-title: J Exp Med – volume: 101 start-page: 4560 year: 2004 end-page: 4565 article-title: Human IL‐23‐producing type 1 macrophages promote but IL‐10‐producing type 2 macrophages subvert immunity to (myco) bacteria publication-title: Proc Natl Acad Sci USA – volume: 278 start-page: 1910 year: 2003 end-page: 1914 article-title: Interleukin‐23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin‐17 publication-title: J Biol Chem – volume: 18 start-page: 1318 year: 2004 end-page: 1320 article-title: Prostaglandin E2 induces IL‐23 production in bone marrow‐derived dendritic cells publication-title: FASEB J – volume: 33 start-page: 3393 year: 2003 end-page: 3397 article-title: IL‐12 receptor deficiency revisited: IL‐23‐mediated signaling is also impaired in human genetic IL‐12 receptor beta1 deficiency publication-title: Eur J Immunol – volume: 158 start-page: 3593 year: 1997 end-page: 3602 article-title: A tumor‐associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL‐12 can prevent or revert the anergic state publication-title: J Immunol – volume: 33 start-page: 1073 year: 2003 end-page: 1083 article-title: Colonic lamina propria dendritic cells in mice with CD4 T cell‐induced colitis publication-title: Eur J Immunol – volume: 9 start-page: 315 year: 1998 end-page: 323 article-title: IL‐12 acts directly on DC to promote nuclear localization of NF‐kappaB and primes DC for IL‐12 production publication-title: Immunity – volume: 168 start-page: 5448 year: 2002 end-page: 5454 article-title: IL‐23 and IL‐12 have overlapping, but distinct, effects on murine dendritic cells publication-title: J Immunol – volume: 161 start-page: 2223 year: 1998 end-page: 2231 article-title: Critical role of IL‐12 in dendritic cell‐induced differentiation of naive B lymphocytes publication-title: J Immunol – volume: 154 start-page: 1606 year: 1995 end-page: 1613 article-title: Role of IL‐12 in human B lymphocyte proliferation and differentiation publication-title: J Immunol – volume: 189 start-page: 1981 year: 1999 end-page: 1986 article-title: Interleukin 12‐dependent interferon gamma production by CD8alpha lymphoid dendritic cells publication-title: J Exp Med – volume: 25 start-page: 1125 year: 1995 end-page: 1128 article-title: Activated T cells induce interleukin‐12 production by monocytes via CD40–CD40 ligand interaction publication-title: Eur J Immunol – volume: 260 start-page: 547 year: 1993 end-page: 549 article-title: Development of TH1 CD4 T cells through IL‐12 produced by ‐induced macrophages publication-title: Science – volume: 197 start-page: 527 year: 2003 end-page: 535 article-title: Low penetrance, broad resistance, and favorable outcome of interleukin 12 receptor beta1 deficiency: medical and immunological implications publication-title: J Exp Med – volume: 156 start-page: 5 year: 1996 end-page: 7 article-title: Mice with a disrupted IFN‐gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE) publication-title: J Immunol – volume: 167 start-page: 5304 year: 2001 end-page: 5315 article-title: IL‐12p40‐dependent agonistic effects on the development of protective innate and adaptive immunity against publication-title: J Immunol – volume: 166 start-page: 7563 year: 2001 end-page: 7570 article-title: Ubiquitous transgenic expression of the IL‐23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death publication-title: J Immunol – volume: 169 start-page: 7104 year: 2002 end-page: 7110 article-title: IL‐12p35‐deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL‐12 system in the induction of central nervous system autoimmune demyelination publication-title: J Immunol – volume: 4 start-page: 355 year: 1992 end-page: 368 article-title: Natural killer cell stimulatory factor (NKSF) or interleukin‐12 is a key regulator of immune response and inflammation publication-title: Prog Growth Factor Res – volume: 1 start-page: 893 year: 1987 end-page: 895 article-title: Exacerbations of multiple sclerosis in patients treated with gamma interferon publication-title: Lancet – volume: 378 start-page: 88 year: 1995 end-page: 91 article-title: Cloning of a new cytokine that induces IFN‐gamma production by T cells publication-title: Nature – ident: e_1_2_7_8_2 doi: 10.1002/eji.1830250133 – volume: 154 start-page: 5071 year: 1995 ident: e_1_2_7_16_2 article-title: Dendritic cells produce IL‐12 and direct the development of Th1 cells from naive CD4+ T cells publication-title: J Immunol doi: 10.4049/jimmunol.154.10.5071 – ident: e_1_2_7_21_2 doi: 10.4049/jimmunol.169.10.5673 – ident: e_1_2_7_43_2 doi: 10.4049/jimmunol.166.12.7563 – ident: e_1_2_7_12_2 doi: 10.1073/pnas.93.24.14002 – ident: e_1_2_7_82_2 doi: 10.1046/j.1523-1747.1998.00347.x – ident: e_1_2_7_85_2 doi: 10.4049/jimmunol.171.11.6173 – ident: e_1_2_7_41_2 doi: 10.4049/jimmunol.166.7.4446 – ident: e_1_2_7_54_2 doi: 10.1046/j.1365-3083.1996.d01-4.x – ident: e_1_2_7_17_2 doi: 10.4049/jimmunol.166.9.5448 – ident: e_1_2_7_46_2 doi: 10.1074/jbc.M207577200 – ident: e_1_2_7_7_2 doi: 10.4049/jimmunol.146.9.3074 – ident: e_1_2_7_57_2 doi: 10.1073/pnas.90.13.6115 – ident: e_1_2_7_24_2 doi: 10.1084/jem.184.2.747 – ident: e_1_2_7_31_2 doi: 10.1074/jbc.M105927200 – ident: e_1_2_7_64_2 doi: 10.4049/jimmunol.173.3.1887 – ident: e_1_2_7_45_2 doi: 10.1016/S0962-8924(00)01856-0 – ident: e_1_2_7_84_2 doi: 10.1189/jlb.71.1.1 – ident: e_1_2_7_40_2 doi: 10.1084/jem.187.12.2103 – ident: e_1_2_7_30_2 doi: 10.1002/eji.200323518 – ident: e_1_2_7_58_2 doi: 10.4049/jimmunol.154.10.5320 – ident: e_1_2_7_27_2 doi: 10.1084/jem.183.1.147 – ident: e_1_2_7_22_2 doi: 10.1002/eji.1830250442 – ident: e_1_2_7_26_2 doi: 10.1186/1471-2172-3-14 – ident: e_1_2_7_75_2 doi: 10.1172/JCI0215751 – ident: e_1_2_7_44_2 doi: 10.4049/jimmunol.168.11.5448 – ident: e_1_2_7_68_2 doi: 10.4049/jimmunol.170.1.597 – ident: e_1_2_7_15_2 doi: 10.1038/41131 – ident: e_1_2_7_74_2 doi: 10.4049/jimmunol.170.4.2153 – ident: e_1_2_7_56_2 doi: 10.4049/jimmunol.172.5.2827 – ident: e_1_2_7_34_2 doi: 10.1016/S1074-7613(00)80614-7 – ident: e_1_2_7_88_2 doi: 10.4049/jimmunol.170.4.2106 – ident: e_1_2_7_55_2 doi: 10.1016/S0020-7519(03)00032-8 – ident: e_1_2_7_61_2 doi: 10.4049/jimmunol.167.9.5304 – ident: e_1_2_7_80_2 doi: 10.1191/135245899678847275 – ident: e_1_2_7_35_2 doi: 10.4049/jimmunol.157.4.1589 – volume: 149 start-page: 3495 year: 1992 ident: e_1_2_7_33_2 article-title: Natural killer (NK) cell stimulatory factor or IL‐12 has differential effects on the proliferation of TCR‐alpha beta+, TCR‐gamma delta+ T lymphocytes, and NK cells publication-title: J Immunol doi: 10.4049/jimmunol.149.11.3495 – ident: e_1_2_7_20_2 doi: 10.4049/jimmunol.167.1.221 – ident: e_1_2_7_79_2 doi: 10.1002/1529-0131(200110)44:10<2413::AID-ART406>3.0.CO;2-E – ident: e_1_2_7_13_2 doi: 10.4049/jimmunol.168.11.5699 – ident: e_1_2_7_10_2 doi: 10.1016/S1074-7613(00)00070-4 – ident: e_1_2_7_28_2 doi: 10.1182/blood-2002-12-3854 – ident: e_1_2_7_70_2 doi: 10.1006/mcne.1998.0725 – volume: 153 start-page: 128 year: 1994 ident: e_1_2_7_11_2 article-title: Expression cloning of a human IL‐12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130 publication-title: J Immunol doi: 10.4049/jimmunol.153.1.128 – volume: 163 start-page: 2517 year: 1999 ident: e_1_2_7_25_2 article-title: Autocrine IL‐12 is involved in dendritic cell modulation via CD40 ligation publication-title: J Immunol doi: 10.4049/jimmunol.163.5.2517 – ident: e_1_2_7_59_2 doi: 10.1128/IAI.66.10.4994-5000.1998 – ident: e_1_2_7_77_2 doi: 10.1084/jem.192.1.123 – volume: 154 start-page: 1606 year: 1995 ident: e_1_2_7_53_2 article-title: Role of IL‐12 in human B lymphocyte proliferation and differentiation publication-title: J Immunol doi: 10.4049/jimmunol.154.4.1606 – ident: e_1_2_7_86_2 doi: 10.1073/pnas.1035999100 – ident: e_1_2_7_29_2 doi: 10.1002/eji.200324815 – ident: e_1_2_7_71_2 doi: 10.1007/BF03401888 – ident: e_1_2_7_67_2 doi: 10.1002/eji.200324343 – ident: e_1_2_7_69_2 doi: 10.1016/S0140-6736(87)92863-7 – ident: e_1_2_7_72_2 doi: 10.4049/jimmunol.156.1.5 – ident: e_1_2_7_32_2 doi: 10.1096/fj.03-1367fje – ident: e_1_2_7_42_2 doi: 10.1073/pnas.1332767100 – ident: e_1_2_7_37_2 doi: 10.1084/jem.189.12.1981 – ident: e_1_2_7_47_2 doi: 10.1084/jem.20030896 – volume: 15 start-page: 5071 year: 1995 ident: e_1_2_7_5_2 article-title: Dendritic cells produce IL‐12 and direct the development of Th1 cells from naive CD4+ T cells publication-title: J Immunol doi: 10.4049/jimmunol.154.10.5071 – ident: e_1_2_7_3_2 doi: 10.1016/0955-2235(92)90016-B – ident: e_1_2_7_14_2 doi: 10.1038/nature01355 – volume: 161 start-page: 2223 year: 1998 ident: e_1_2_7_52_2 article-title: Critical role of IL‐12 in dendritic cell‐induced differentiation of naive B lymphocytes publication-title: J Immunol doi: 10.4049/jimmunol.161.5.2223 – ident: e_1_2_7_66_2 doi: 10.1084/jem.20021769 – ident: e_1_2_7_4_2 doi: 10.1126/science.8097338 – ident: e_1_2_7_65_2 doi: 10.1182/blood-2004-02-0584 – ident: e_1_2_7_87_2 doi: 10.1002/1521-4141(200203)32:3<686::AID-IMMU686>3.0.CO;2-I – ident: e_1_2_7_39_2 doi: 10.4049/jimmunol.164.1.64 – ident: e_1_2_7_51_2 doi: 10.1002/eji.1830260134 – ident: e_1_2_7_60_2 doi: 10.4049/jimmunol.165.2.628 – ident: e_1_2_7_23_2 doi: 10.1002/eji.1830260705 – volume: 157 start-page: 3223 year: 1996 ident: e_1_2_7_73_2 article-title: IFN‐gamma plays a critical down‐regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein‐induced autoimmune encephalomyelitis publication-title: J Immunol doi: 10.4049/jimmunol.157.8.3223 – ident: e_1_2_7_81_2 doi: 10.4049/jimmunol.164.5.2832 – ident: e_1_2_7_76_2 doi: 10.4049/jimmunol.169.12.7104 – ident: e_1_2_7_9_2 doi: 10.1038/nri1001 – ident: e_1_2_7_18_2 doi: 10.1073/pnas.0400983101 – ident: e_1_2_7_49_2 doi: 10.1038/ni832 – ident: e_1_2_7_63_2 doi: 10.1128/IAI.70.4.1936-1948.2002 – ident: e_1_2_7_6_2 doi: 10.1146/annurev.immunol.16.1.495 – volume: 158 start-page: 3593 year: 1997 ident: e_1_2_7_36_2 article-title: A tumor‐associated and self antigen peptide presented by dendritic cells may induce T cell anergy in vivo, but IL‐12 can prevent or revert the anergic state publication-title: J Immunol doi: 10.4049/jimmunol.158.8.3593 – ident: e_1_2_7_19_2 doi: 10.4049/jimmunol.167.2.957 – ident: e_1_2_7_38_2 doi: 10.1038/378088a0 – ident: e_1_2_7_48_2 doi: 10.4049/jimmunol.170.9.4432 – ident: e_1_2_7_78_2 doi: 10.4049/jimmunol.158.11.5507 – ident: e_1_2_7_50_2 doi: 10.1172/JCI17321 – ident: e_1_2_7_83_2 doi: 10.4049/jimmunol.165.11.6107 – ident: e_1_2_7_2_2 doi: 10.1084/jem.170.3.827 – ident: e_1_2_7_62_2 doi: 10.4049/jimmunol.168.3.1322 |
| SSID | ssj0017324 |
| Score | 2.391067 |
| SecondaryResourceType | review_article |
| Snippet | Initiation of an effective immune response requires close interactions between innate and adaptive immunity. Recent advances in the field of cytokine biology... |
| SourceID | proquest pubmed crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 96 |
| SubjectTerms | Animals Autoimmunity - immunology Autoimmunity - physiology B-Lymphocytes - immunology B-Lymphocytes - physiology Communicable Diseases - immunology Communicable Diseases - metabolism Humans Immunity, Innate - immunology Immunity, Innate - physiology Interleukin-12 - immunology Interleukin-12 - physiology Interleukin-23 Interleukin-23 Subunit p19 Interleukins - immunology Interleukins - physiology Receptors, Interleukin - immunology Receptors, Interleukin - physiology |
| Title | IL-12 and IL-23: master regulators of innate and adaptive immunity |
| URI | https://api.istex.fr/ark:/67375/WNG-04WQ4V4Z-W/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.0105-2896.2004.00214.x https://www.ncbi.nlm.nih.gov/pubmed/15546388 https://www.proquest.com/docview/67079636 |
| Volume | 202 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LTx0hFCZGY9JNH_bhtFpZNN3NzTxgBrprjLdqqklN7TXdEDhAYm4719xHol35E_ob_SVymLnX3MaFadyx4AADHPhgPr5DyAfgILS0WZrb4G5hx2ep1Mak3kvjJQjrLV7oHx1X-6fs8IyfdfwnfAvT6kMsLtzQM-J6jQ6uzWTJyTG4YxoODJFpgCLYRc56iCeRuoX46GShJJXXZdHKfHcmS6Se-wta2qnWsNMv74Ohy6g2bkv9Z2Q4_6CWjTLszaamB3_-0Xp8nC9-Tp526JV-bqfbC7Limg2y3sazvHpJ-gdfb67_5gXVjaUxXZSf6G-NYgx03Ea9H40ndOTpedMElBszaqsvcNGl5_GtyvTqFTnt733f3U-7QA0psEqwtDClAQc-ty54eAaWCyFDMx2vAAI-c1L40kgnOVQGvA1HGFNCzX2ogIEV5Wuy2owat0koDyUVWeVMJixzVkuNPJ2s5AAFd94lpJ4PioJOxRyDafxSd6cZ7CWFvYQxNpmKvaQuE5IvLC9aJY8H2HyM474w0OMhMuFqrgbHX1TGBt_YD_ZTDRKyM58YKvgn_nTRjRvNJiF3VodFrkrIm3a-3FWOBMFSiITwOOoPbpU6ODoJibf_afeOPJmrVWb5FlmdjmduOyCrqXkffeYWRSsTbA |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxEB6hVgguvCnLqz4gbhvtw961uSEgJJBEompJxcXyU6paNlWaSC0nfgK_kV-Cx7tJFdRDhbj54PFj7LHH9vj7AF4ZZrgSNktzG8wt7Pg0FUrr1HuhvTDceosX-uNJNTignw7ZYUcHhH9hWnyI9YUbWkZcr9HA8UJ6w8qR3TENJ4YYaoAo2EVOe8Gh3EaCbwTSf7-3xpLK67Jogb47mY2wnqtL2tirtlHt51c5opt-bdyY-nfhZNWlNh7luLdc6J758Rfa43_q8z240zmw5G074-7DDdc8gJstpeXFQ-gPR79__soLohpLYroo35DvCvEYyLwlvp_Nz8jMk6OmCY5uzKisOsV1lxzF7yqLi0dw0P-w_26QdlwNqaEVp2mhS22c8bl1wcgzYxnnIjTTscqY4KI5wX2phRPMVNp4G04xujQ186ECaiwvH8NWM2vcEyAslFRkldMZt9RZJRSG6mQlM6ZgzrsE6tWoSNMBmSOfxom8PNCgliRqCWk2qYxakucJ5GvJ0xbM4xoyr-PArwXU_BiD4Womp5OPMqPTL_Qr_SanCeyuZoYMJorvLqpxs-VZyJ3VYZ2rEthpJ8xl5RgjWHKeAIvDfu1WyeF4LySe_qPcLtwa7I9HcjScfH4Gt1fglVn-HLYW86V7ERythX4ZDegPi8UXiA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1LbxMxEB6hViAuvCnLq3tA3Dby7tq7NjfUEhpoI6goqbhYfkpVYBOlidRy4ifwG_tL8Hg3qYJ6qBA3Hzx-jD322P78DcArwwxXwpIst8Hcwo5PM6G0zrwX2gvDrbd4oX8wrPaO6Idjdtzhn_AvTMsPsbpwQ8uI6zUa-NT6NSPH4I5ZODBEpAGSYBc57QV_cpNWRGAYh93DFZVUXpdFy_Pdyayheq4uaW2r2kStn13lh667tXFf6t-F8bJHLRxl3FvMdc_8_Ivs8f90-R7c6dzX9G073-7DDdc8gJttQMvzh9Af7F_8-p0XqWpsGtNF-Sb9oZCNIZ21Ye8ns9N04tOTpglubsyorJriqpuexM8q8_NHcNR_92VnL-siNWSGVpxmhS61ccbn1gUTJ8YyzkVopmOVMcFBc4L7UgsnmKm08TacYXRpauZDBdRYXj6GjWbSuCeQslBSQSqnCbfUWSUUAnVIyYwpmPMugXo5KNJ0NOYYTeO7vDzOoJYkagmDbFIZtSTPEshXktOWyuMaMq_juK8E1GyMULiaydHwvSR09Jl-pd_kKIHt5cSQwUDx1UU1brI4DblJHVa5KoGtdr5cVo4IwZLzBFgc9Wu3Sg4ODkPi6T_KbcOtT7t9uT8YfnwGt5fMlSR_Dhvz2cK9CF7WXL-M5vMHHn0WNw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IL%E2%80%9012+and+IL%E2%80%9023%3A+master+regulators+of+innate+and+adaptive+immunity&rft.jtitle=Immunological+reviews&rft.au=Langrish%2C+Claire+L.&rft.au=McKenzie%2C+Brent+S.&rft.au=Wilson%2C+Nicholas+J.&rft.au=De+Waal+Malefyt%2C+Rene&rft.date=2004-12-01&rft.issn=0105-2896&rft.eissn=1600-065X&rft.volume=202&rft.issue=1&rft.spage=96&rft.epage=105&rft_id=info:doi/10.1111%2Fj.0105-2896.2004.00214.x&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_j_0105_2896_2004_00214_x |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0105-2896&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0105-2896&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0105-2896&client=summon |