Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff
Synopsis Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti‐dandruff shampoo not only has to provide superior anti‐dandruff relief to ensure patient compliance. It also needs to offer excellent cosmetic and hair conditioning benefits at the same time. In thi...
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| Published in | International journal of cosmetic science Vol. 33; no. 3; pp. 276 - 282 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.06.2011
Wiley |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Synopsis
Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti‐dandruff shampoo not only has to provide superior anti‐dandruff relief to ensure patient compliance. It also needs to offer excellent cosmetic and hair conditioning benefits at the same time. In this study, the efficacy of a shampoo containing 0.5% piroctone olamine and 0.45% climbazole (shampoo 1) was compared with a widely available commercial shampoo containing 1% zinc pyrithione (shampoo 2). In vitro studies investigating the anti‐mycotic efficacy of a combination of 0.5% piroctone olamine and 0.45% climbazole as well as 1% zinc pyrithione were performed. To study substantivity, pig skin punches were used as a model system and a test of wet combability was performed to characterize combing ease. In vivo home‐in‐use studies were carried out to determine the efficacy of both shampoos to improve scalp condition and reduce itching in subjects suffering from moderate to severe dandruff. Results demonstrated a comparable anti‐fungal effectiveness for 0.5% piroctone olamine plus 0.45% climbazole and 1% zinc pyrithione, respectively. Shampoo 1 showed a significantly higher anti‐mycotics substantivity compared to shampoo 2. After treatment with shampoo 1, the wet combing force was significantly reduced compared with shampoo 2, suggesting a better combability following the use of shampoo 1. In an in vivo split head design study, shampoo 1 was shown to be equally effective in reducing the amount of dandruff on the scalp compared with shampoo 2. The approval rate of volunteers regarding the question ‘The use of this shampoo decreases the itching of my scalp?’ after a 4‐week treatment with shampoo 1 equaled 90%. Overall, the shampoo formulation with 0.5% piroctone olamine and 0.45% climbazole effectively reduces the amount of dandruff and, at the same time, provides hair conditioning advantages.
Résumé
Les pellicules sont une affection chronique du cuir chevelu qui se caractérise par une desquamation et des démangeaisons de l’épiderme. Aujourd’hui, un shampooing antipelliculaire performant doit non seulement apporter un soulagement notoire en vue de garantir la fidélisation du patient mais également, prendre soin du cheveu et lui apporter de la cosmeticité. Dans la présente étude, on a comparé l’efficacité d’un shampooing contenant 0.5% de piroctone olamine et 0.45% de climbazole (shampooing 1) à celle d’un shampooing largement répandu dans le commerce contenant 1% de zinc pyrithione (shampooing 2). Des études in vitro destinées à examiner l’efficacité antifongique d’une formulation contenant 0.5% de piroctone olamine et 0.45% de climbazole ainsi que d’une formulation contenant 1% de zinc pyrithione ont été réalisées. D’une part, afin d’étudier la substantivité de ces agents actifs, des biopsies de peau de porc ont été utilisées comme système modèle et d’autre part un test de peignage sur mèche de cheveux humides a été réalisé pour évaluer la facilité du passage du peigne. De plus avec ces deux shampoings des tests à domicile ont été effectués sur des sujets souffrant de problèmes pelliculaires modérés à graves afin de déterminer l’ efficacité d’amélioration de la condition du cuir chevelu et de la réduction des démangeaisons. Les résultats ont démontré une efficacité antifongique de la formulation 0.5% de piroctone olamine plus 0.45% de climbazole comparable à celle de 1% de zinc pyrithione. Le shampooing 1 a montré une substantivité antifongique significativement plus élevée que celle du shampooing 2. Après le traitement effectué avec le shampooing 1, la force de peignage humide avait significativement diminué en comparaison avec celle du shampooing 2, indiquant un meilleur passage de peigne après l’utilisation du shampooing 1. Dans un test de comparaison en demi‐tête, le shampooing 1 s’est montré tout aussi efficace quant à la réduction de la quantité de pellicules sur le cuir chevelu, comparé au shampooing 2. Après 4 semaines de traitement avec le shampooing 1, le taux d’acceptation des volontaires concernant la question de savoir si ‘L’utilisation de ce shampooing diminue les démangeaisons de mon cuir chevelu?’était de 90%. L’ensemble des études réalisées permet de conclure que la formulation du shampooing contenant 0.5% de piroctone olamine plus 0.45% de climbazole réduit efficacement la quantité de pellicules tout en prenant soin du cheveu, grâce à sa performance cosmétique. |
|---|---|
| AbstractList | Synopsis
Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti‐dandruff shampoo not only has to provide superior anti‐dandruff relief to ensure patient compliance. It also needs to offer excellent cosmetic and hair conditioning benefits at the same time. In this study, the efficacy of a shampoo containing 0.5% piroctone olamine and 0.45% climbazole (shampoo 1) was compared with a widely available commercial shampoo containing 1% zinc pyrithione (shampoo 2). In vitro studies investigating the anti‐mycotic efficacy of a combination of 0.5% piroctone olamine and 0.45% climbazole as well as 1% zinc pyrithione were performed. To study substantivity, pig skin punches were used as a model system and a test of wet combability was performed to characterize combing ease. In vivo home‐in‐use studies were carried out to determine the efficacy of both shampoos to improve scalp condition and reduce itching in subjects suffering from moderate to severe dandruff. Results demonstrated a comparable anti‐fungal effectiveness for 0.5% piroctone olamine plus 0.45% climbazole and 1% zinc pyrithione, respectively. Shampoo 1 showed a significantly higher anti‐mycotics substantivity compared to shampoo 2. After treatment with shampoo 1, the wet combing force was significantly reduced compared with shampoo 2, suggesting a better combability following the use of shampoo 1. In an in vivo split head design study, shampoo 1 was shown to be equally effective in reducing the amount of dandruff on the scalp compared with shampoo 2. The approval rate of volunteers regarding the question ‘The use of this shampoo decreases the itching of my scalp?’ after a 4‐week treatment with shampoo 1 equaled 90%. Overall, the shampoo formulation with 0.5% piroctone olamine and 0.45% climbazole effectively reduces the amount of dandruff and, at the same time, provides hair conditioning advantages.
Résumé
Les pellicules sont une affection chronique du cuir chevelu qui se caractérise par une desquamation et des démangeaisons de l’épiderme. Aujourd’hui, un shampooing antipelliculaire performant doit non seulement apporter un soulagement notoire en vue de garantir la fidélisation du patient mais également, prendre soin du cheveu et lui apporter de la cosmeticité. Dans la présente étude, on a comparé l’efficacité d’un shampooing contenant 0.5% de piroctone olamine et 0.45% de climbazole (shampooing 1) à celle d’un shampooing largement répandu dans le commerce contenant 1% de zinc pyrithione (shampooing 2). Des études in vitro destinées à examiner l’efficacité antifongique d’une formulation contenant 0.5% de piroctone olamine et 0.45% de climbazole ainsi que d’une formulation contenant 1% de zinc pyrithione ont été réalisées. D’une part, afin d’étudier la substantivité de ces agents actifs, des biopsies de peau de porc ont été utilisées comme système modèle et d’autre part un test de peignage sur mèche de cheveux humides a été réalisé pour évaluer la facilité du passage du peigne. De plus avec ces deux shampoings des tests à domicile ont été effectués sur des sujets souffrant de problèmes pelliculaires modérés à graves afin de déterminer l’ efficacité d’amélioration de la condition du cuir chevelu et de la réduction des démangeaisons. Les résultats ont démontré une efficacité antifongique de la formulation 0.5% de piroctone olamine plus 0.45% de climbazole comparable à celle de 1% de zinc pyrithione. Le shampooing 1 a montré une substantivité antifongique significativement plus élevée que celle du shampooing 2. Après le traitement effectué avec le shampooing 1, la force de peignage humide avait significativement diminué en comparaison avec celle du shampooing 2, indiquant un meilleur passage de peigne après l’utilisation du shampooing 1. Dans un test de comparaison en demi‐tête, le shampooing 1 s’est montré tout aussi efficace quant à la réduction de la quantité de pellicules sur le cuir chevelu, comparé au shampooing 2. Après 4 semaines de traitement avec le shampooing 1, le taux d’acceptation des volontaires concernant la question de savoir si ‘L’utilisation de ce shampooing diminue les démangeaisons de mon cuir chevelu?’était de 90%. L’ensemble des études réalisées permet de conclure que la formulation du shampooing contenant 0.5% de piroctone olamine plus 0.45% de climbazole réduit efficacement la quantité de pellicules tout en prenant soin du cheveu, grâce à sa performance cosmétique. Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti-dandruff shampoo not only has to provide superior anti-dandruff relief to ensure patient compliance. It also needs to offer excellent cosmetic and hair conditioning benefits at the same time. In this study, the efficacy of a shampoo containing 0.5% piroctone olamine and 0.45% climbazole (shampoo 1) was compared with a widely available commercial shampoo containing 1% zinc pyrithione (shampoo 2). In vitro studies investigating the anti-mycotic efficacy of a combination of 0.5% piroctone olamine and 0.45% climbazole as well as 1% zinc pyrithione were performed. To study substantivity, pig skin punches were used as a model system and a test of wet combability was performed to characterize combing ease. In vivo home-in-use studies were carried out to determine the efficacy of both shampoos to improve scalp condition and reduce itching in subjects suffering from moderate to severe dandruff. Results demonstrated a comparable anti-fungal effectiveness for 0.5% piroctone olamine plus 0.45% climbazole and 1% zinc pyrithione, respectively. Shampoo 1 showed a significantly higher anti-mycotics substantivity compared to shampoo 2. After treatment with shampoo 1, the wet combing force was significantly reduced compared with shampoo 2, suggesting a better combability following the use of shampoo 1. In an in vivo split head design study, shampoo 1 was shown to be equally effective in reducing the amount of dandruff on the scalp compared with shampoo 2. The approval rate of volunteers regarding the question 'The use of this shampoo decreases the itching of my scalp?' after a 4-week treatment with shampoo 1 equaled 90%. Overall, the shampoo formulation with 0.5% piroctone olamine and 0.45% climbazole effectively reduces the amount of dandruff and, at the same time, provides hair conditioning advantages. Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti‐dandruff shampoo not only has to provide superior anti‐dandruff relief to ensure patient compliance. It also needs to offer excellent cosmetic and hair conditioning benefits at the same time. In this study, the efficacy of a shampoo containing 0.5% piroctone olamine and 0.45% climbazole (shampoo 1) was compared with a widely available commercial shampoo containing 1% zinc pyrithione (shampoo 2). In vitro studies investigating the anti‐mycotic efficacy of a combination of 0.5% piroctone olamine and 0.45% climbazole as well as 1% zinc pyrithione were performed. To study substantivity, pig skin punches were used as a model system and a test of wet combability was performed to characterize combing ease. In vivo home‐in‐use studies were carried out to determine the efficacy of both shampoos to improve scalp condition and reduce itching in subjects suffering from moderate to severe dandruff. Results demonstrated a comparable anti‐fungal effectiveness for 0.5% piroctone olamine plus 0.45% climbazole and 1% zinc pyrithione, respectively. Shampoo 1 showed a significantly higher anti‐mycotics substantivity compared to shampoo 2. After treatment with shampoo 1, the wet combing force was significantly reduced compared with shampoo 2, suggesting a better combability following the use of shampoo 1. In an in vivo split head design study, shampoo 1 was shown to be equally effective in reducing the amount of dandruff on the scalp compared with shampoo 2. The approval rate of volunteers regarding the question ‘The use of this shampoo decreases the itching of my scalp?’ after a 4‐week treatment with shampoo 1 equaled 90%. Overall, the shampoo formulation with 0.5% piroctone olamine and 0.45% climbazole effectively reduces the amount of dandruff and, at the same time, provides hair conditioning advantages. Les pellicules sont une affection chronique du cuir chevelu qui se caractérise par une desquamation et des démangeaisons de l’épiderme. Aujourd’hui, un shampooing antipelliculaire performant doit non seulement apporter un soulagement notoire en vue de garantir la fidélisation du patient mais également, prendre soin du cheveu et lui apporter de la cosmeticité. Dans la présente étude, on a comparé l’efficacité d’un shampooing contenant 0.5% de piroctone olamine et 0.45% de climbazole (shampooing 1) à celle d’un shampooing largement répandu dans le commerce contenant 1% de zinc pyrithione (shampooing 2). Des études in vitro destinées à examiner l’efficacité antifongique d’une formulation contenant 0.5% de piroctone olamine et 0.45% de climbazole ainsi que d’une formulation contenant 1% de zinc pyrithione ont été réalisées. D’une part, afin d’étudier la substantivité de ces agents actifs, des biopsies de peau de porc ont été utilisées comme système modèle et d’autre part un test de peignage sur mèche de cheveux humides a été réalisé pour évaluer la facilité du passage du peigne. De plus avec ces deux shampoings des tests à domicile ont été effectués sur des sujets souffrant de problèmes pelliculaires modérés à graves afin de déterminer l’ efficacité d’amélioration de la condition du cuir chevelu et de la réduction des démangeaisons. Les résultats ont démontré une efficacité antifongique de la formulation 0.5% de piroctone olamine plus 0.45% de climbazole comparable à celle de 1% de zinc pyrithione. Le shampooing 1 a montré une substantivité antifongique significativement plus élevée que celle du shampooing 2. Après le traitement effectué avec le shampooing 1, la force de peignage humide avait significativement diminué en comparaison avec celle du shampooing 2, indiquant un meilleur passage de peigne après l’utilisation du shampooing 1. Dans un test de comparaison en demi‐tête, le shampooing 1 s’est montré tout aussi efficace quant à la réduction de la quantité de pellicules sur le cuir chevelu, comparé au shampooing 2. Après 4 semaines de traitement avec le shampooing 1, le taux d’acceptation des volontaires concernant la question de savoir si ‘L’utilisation de ce shampooing diminue les démangeaisons de mon cuir chevelu?’était de 90%. L’ensemble des études réalisées permet de conclure que la formulation du shampooing contenant 0.5% de piroctone olamine plus 0.45% de climbazole réduit efficacement la quantité de pellicules tout en prenant soin du cheveu, grâce à sa performance cosmétique. Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti-dandruff shampoo not only has to provide superior anti-dandruff relief to ensure patient compliance. It also needs to offer excellent cosmetic and hair conditioning benefits at the same time. In this study, the efficacy of a shampoo containing 0.5% piroctone olamine and 0.45% climbazole (shampoo 1) was compared with a widely available commercial shampoo containing 1% zinc pyrithione (shampoo 2). In vitro studies investigating the anti-mycotic efficacy of a combination of 0.5% piroctone olamine and 0.45% climbazole as well as 1% zinc pyrithione were performed. To study substantivity, pig skin punches were used as a model system and a test of wet combability was performed to characterize combing ease. In vivo home-in-use studies were carried out to determine the efficacy of both shampoos to improve scalp condition and reduce itching in subjects suffering from moderate to severe dandruff. Results demonstrated a comparable anti-fungal effectiveness for 0.5% piroctone olamine plus 0.45% climbazole and 1% zinc pyrithione, respectively. Shampoo 1 showed a significantly higher anti-mycotics substantivity compared to shampoo 2. After treatment with shampoo 1, the wet combing force was significantly reduced compared with shampoo 2, suggesting a better combability following the use of shampoo 1. In an in vivo split head design study, shampoo 1 was shown to be equally effective in reducing the amount of dandruff on the scalp compared with shampoo 2. The approval rate of volunteers regarding the question 'The use of this shampoo decreases the itching of my scalp?' after a 4-week treatment with shampoo 1 equaled 90%. Overall, the shampoo formulation with 0.5% piroctone olamine and 0.45% climbazole effectively reduces the amount of dandruff and, at the same time, provides hair conditioning advantages.Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti-dandruff shampoo not only has to provide superior anti-dandruff relief to ensure patient compliance. It also needs to offer excellent cosmetic and hair conditioning benefits at the same time. In this study, the efficacy of a shampoo containing 0.5% piroctone olamine and 0.45% climbazole (shampoo 1) was compared with a widely available commercial shampoo containing 1% zinc pyrithione (shampoo 2). In vitro studies investigating the anti-mycotic efficacy of a combination of 0.5% piroctone olamine and 0.45% climbazole as well as 1% zinc pyrithione were performed. To study substantivity, pig skin punches were used as a model system and a test of wet combability was performed to characterize combing ease. In vivo home-in-use studies were carried out to determine the efficacy of both shampoos to improve scalp condition and reduce itching in subjects suffering from moderate to severe dandruff. Results demonstrated a comparable anti-fungal effectiveness for 0.5% piroctone olamine plus 0.45% climbazole and 1% zinc pyrithione, respectively. Shampoo 1 showed a significantly higher anti-mycotics substantivity compared to shampoo 2. After treatment with shampoo 1, the wet combing force was significantly reduced compared with shampoo 2, suggesting a better combability following the use of shampoo 1. In an in vivo split head design study, shampoo 1 was shown to be equally effective in reducing the amount of dandruff on the scalp compared with shampoo 2. The approval rate of volunteers regarding the question 'The use of this shampoo decreases the itching of my scalp?' after a 4-week treatment with shampoo 1 equaled 90%. Overall, the shampoo formulation with 0.5% piroctone olamine and 0.45% climbazole effectively reduces the amount of dandruff and, at the same time, provides hair conditioning advantages. Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti-dandruff shampoo not only has to provide superior anti-dandruff relief to ensure patient compliance. It also needs to offer excellent cosmetic and hair conditioning benefits at the same time. In this study, the efficacy of a shampoo containing 0.5% piroctone olamine and 0.45% climbazole (shampoo 1) was compared with a widely available commercial shampoo containing 1% zinc pyrithione (shampoo 2). In vitro studies investigating the anti-mycotic efficacy of a combination of 0.5% piroctone olamine and 0.45% climbazole as well as 1% zinc pyrithione were performed. To study substantivity, pig skin punches were used as a model system and a test of wet combability was performed to characterize combing ease. In vivo home-in-use studies were carried out to determine the efficacy of both shampoos to improve scalp condition and reduce itching in subjects suffering from moderate to severe dandruff. Results demonstrated a comparable anti-fungal effectiveness for 0.5% piroctone olamine plus 0.45% climbazole and 1% zinc pyrithione, respectively. Shampoo 1 showed a significantly higher anti-mycotics substantivity compared to shampoo 2. After treatment with shampoo 1, the wet combing force was significantly reduced compared with shampoo 2, suggesting a better combability following the use of shampoo 1. In an in vivo split head design study, shampoo 1 was shown to be equally effective in reducing the amount of dandruff on the scalp compared with shampoo 2. The approval rate of volunteers regarding the question 'The use of this shampoo decreases the itching of my scalp?' after a 4-week treatment with shampoo 1 equaled 90%. Overall, the shampoo formulation with 0.5% piroctone olamine and 0.45% climbazole effectively reduces the amount of dandruff and, at the same time, provides hair conditioning advantages.Original Abstract: Les pellicules sont une affection chronique du cuir chevelu qui se caracterise par une desquamation et des demangeaisons de l'epiderme. Aujourd'hui, un shampooing antipelliculaire performant doit non seulement apporter un soulagement notoire en vue de garantir la fidelisation du patient mais egalement, prendre soin du cheveu et lui apporter de la cosmeticite. Dans la presente etude, on a compare l'efficacite d'un shampooing contenant 0.5% de piroctone olamine et 0.45% de climbazole (shampooing 1) a celle d'un shampooing largement repandu dans le commerce contenant 1% de zinc pyrithione (shampooing 2). Des etudes in vitro destinees a examiner l'efficacite antifongique d'une formulation contenant 0.5% de piroctone olamine et 0.45% de climbazole ainsi que d'une formulation contenant 1% de zinc pyrithione ont ete realisees. D'une part, afin d'etudier la substantivite de ces agents actifs, des biopsies de peau de porc ont ete utilisees comme systeme modele et d'autre part un test de peignage sur meche de cheveux humides a ete realise pour evaluer la facilite du passage du peigne. De plus avec ces deux shampoings des tests a domicile ont ete effectues sur des sujets souffrant de problemes pelliculaires moderes a graves afin de determiner l' efficacite d'amelioration de la condition du cuir chevelu et de la reduction des demangeaisons. Les resultats ont demontre une efficacite antifongique de la formulation 0.5% de piroctone olamine plus 0.45% de climbazole comparable a celle de 1% de zinc pyrithione. Le shampooing 1 a montre une substantivite antifongique significativement plus elevee que celle du shampooing 2. Apres le traitement effectue avec le shampooing 1, la force de peignage humide avait significativement diminue en comparaison avec celle du shampooing 2, indiquant un meilleur passage de peigne apres l'utilisation du shampooing 1. Dans un test de comparaison en demi-tete, le shampooing 1 s'est montre tout aussi efficace quant a la reduction de la quantite de pellicules sur le cuir chevelu, compare au shampooing 2. Apres 4 semaines de traitement avec le shampooing 1, le taux d'acceptation des volontaires concernant la question de savoir si 'L'utilisation de ce shampooing diminue les demangeaisons de mon cuir chevelu?'etait de 90%. L'ensemble des etudes realisees permet de conclure que la formulation du shampooing contenant 0.5% de piroctone olamine plus 0.45% de climbazole reduit efficacement la quantite de pellicules tout en prenant soin du cheveu, grace a sa performance cosmetique. |
| Author | Fey, S. Braren, S. Hillemann, T. Oltrogge, B. Weets, G. Schmidt-Rose, T. Philipp, P. Fölster, H. |
| Author_xml | – sequence: 1 givenname: T. surname: Schmidt-Rose fullname: Schmidt-Rose, T. organization: Research & Development, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany – sequence: 2 givenname: S. surname: Braren fullname: Braren, S. organization: Research & Development, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany – sequence: 3 givenname: H. surname: Fölster fullname: Fölster, H. organization: Research & Development, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany – sequence: 4 givenname: T. surname: Hillemann fullname: Hillemann, T. organization: Research & Development, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany – sequence: 5 givenname: B. surname: Oltrogge fullname: Oltrogge, B. organization: Research & Development, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany – sequence: 6 givenname: P. surname: Philipp fullname: Philipp, P. organization: Research & Development, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany – sequence: 7 givenname: G. surname: Weets fullname: Weets, G. organization: Research & Development, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany – sequence: 8 givenname: S. surname: Fey fullname: Fey, S. organization: Research & Development, Beiersdorf AG, Unnastrasse 48, 20245 Hamburg, Germany |
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| Keywords | Cosmetic shampoo Skin disease piroctone olamine Volunteer Pyridine derivatives Antifungal agent Ungulata Climbazole Human zinc pyrithione Transition metal In vitro Antidandruff shampoo Biological activity Dandruff Pig In vivo Vertebrata Mammalia Penetration Treatment Scalp Animal Skin Pyrithione zinc Artiodactyla Hair product Comparative study |
| Language | English |
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| References | Elewski, B.E. Clinical diagnosis of common scalp disorders. J. Investig. Dermatol. Symp. Proc. 10(3), 190-193 (2005). Trüeb, R.M. Dermocosmetic aspects of hair and scalp. J. Investig. Dermatol. Symp. Proc. 10(3), 289-292 (2005). Draelos, Z.D., Kenneally, D.C., Hodges, L.T., Billhimer, W., Copas, M. and Margraf, C. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos. J. Investig. Dermatol. Symp. Proc. 10(3), 201-204 (2005). Mayser, P., Argembeaux, H. and Rippke, F. The hair strand test - a new method for testing anti-fungal effects of anti-dandruff preparations. J. Cosmet. Sci. 54(3), 263-270 (2003). Rasband, W.S. ImageJ, U.S. National Institutes of Health, Bethesda, Maryland, USA (19972008), http://rsb.info.nih.gov/ij/ . Trüeb, R.M. The value of hair cosmetics and pharmaceuticals. Dermatology 202(4), 275-282 (2001). Schwartz, J.R. Product pharmacology and medical actives in achieving therapeutic benefits. J. Investig. Dermatol. Symp. Proc. 10(3), 198-200 (2005). Kaneko, T., Makimura, K., Abe, M. et al. Revised culture-based system for identification of Malassezia species. J. Clin. Microbiol. 45(11), 3737-3742 (2007). Westlake, W.J. Use of confidence intervals in analysis of comparative bioavailability trials. J. Pharm. Sci. 61(8), 1340-1341 (1972). Bailey, P., Arrowsmith, C., Darling, K. et al. A double-blind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity. Int J Cosmet Sci. 25(4), 183-188 (2003). Wigger-Alberti, W., Kluge, K. and Elsner, P. Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema. Praxis (Bern 1994) 90(33), 1346-1349 (2001). Gupta, A.K., Batra, R., Bluhm, R., Boekhout, T. and Dawson Jr, T.L. Skin diseases associated with Malassezia species. J. Am. Acad. Dermatol. 51(5), 785-798 (2004). Wellek, S. Testing Statistical Hypotheses of Equivalence. Chapman & Hall/CRC Press, Boca Raton, Fl. (2003). Nakajima, K., Yasuda, T. and Nakazawa, H. High-performance liquid chromatographic determination of zinc pyrithione in antidandruff preparations based on copper chelate formation. J. Chromatogr. 502(2), 379-384 (1990). Shuster, S. The aetiology of dandruff and the mode of action of therapeutic agents. Br. J. Dermatol. 111(2), 235-242 (1984). Lodén, M. and Wessman, C. The anti-dandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo. Int J Cosmet Sci. 22(4), 285-289 (2000). Pérez-Rivera, A.A., Hu, T., Aardema, M.J. and Nash, J.F. Evaluation of the genotoxicity of the imidazole anti-fungal climbazole: comparison to published results for other azole compounds. Mutat. Res. 672(1), 27-39 (2009). Futterer, E. Evaluation of efficacy of anti-dandruff agents. J. Soc Cosmet. Chem. 32, 327-338 (1981). 2004; 51 1990; 502 2001; 90 1990 1984; 111 2000; 22 1972; 61 2009; 672 2003; 25 2005; 10 19972008 2004 2003 2007; 45 1981; 32 2003; 54 2001; 202 e_1_2_7_5_2 e_1_2_7_4_2 e_1_2_7_3_2 Wigger‐Alberti W. (e_1_2_7_21_2) 2001; 90 e_1_2_7_9_2 e_1_2_7_8_2 Schwartz J.R. (e_1_2_7_2_2) 2004 e_1_2_7_7_2 e_1_2_7_6_2 e_1_2_7_19_2 e_1_2_7_18_2 Futterer E. (e_1_2_7_20_2) 1981; 32 e_1_2_7_16_2 Wellek S. (e_1_2_7_14_2) 2003 e_1_2_7_15_2 e_1_2_7_13_2 e_1_2_7_12_2 e_1_2_7_10_2 Mayser P. (e_1_2_7_17_2) 2003; 54 Rasband W.S. (e_1_2_7_11_2) 1997 |
| References_xml | – reference: Draelos, Z.D., Kenneally, D.C., Hodges, L.T., Billhimer, W., Copas, M. and Margraf, C. A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos. J. Investig. Dermatol. Symp. Proc. 10(3), 201-204 (2005). – reference: Bailey, P., Arrowsmith, C., Darling, K. et al. A double-blind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity. Int J Cosmet Sci. 25(4), 183-188 (2003). – reference: Trüeb, R.M. The value of hair cosmetics and pharmaceuticals. Dermatology 202(4), 275-282 (2001). – reference: Wigger-Alberti, W., Kluge, K. and Elsner, P. Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema. Praxis (Bern 1994) 90(33), 1346-1349 (2001). – reference: Shuster, S. The aetiology of dandruff and the mode of action of therapeutic agents. Br. J. Dermatol. 111(2), 235-242 (1984). – reference: Pérez-Rivera, A.A., Hu, T., Aardema, M.J. and Nash, J.F. Evaluation of the genotoxicity of the imidazole anti-fungal climbazole: comparison to published results for other azole compounds. Mutat. Res. 672(1), 27-39 (2009). – reference: Lodén, M. and Wessman, C. The anti-dandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo. Int J Cosmet Sci. 22(4), 285-289 (2000). – reference: Kaneko, T., Makimura, K., Abe, M. et al. Revised culture-based system for identification of Malassezia species. J. Clin. Microbiol. 45(11), 3737-3742 (2007). – reference: Schwartz, J.R. Product pharmacology and medical actives in achieving therapeutic benefits. J. Investig. Dermatol. Symp. Proc. 10(3), 198-200 (2005). – reference: Futterer, E. Evaluation of efficacy of anti-dandruff agents. J. Soc Cosmet. Chem. 32, 327-338 (1981). – reference: Nakajima, K., Yasuda, T. and Nakazawa, H. High-performance liquid chromatographic determination of zinc pyrithione in antidandruff preparations based on copper chelate formation. J. Chromatogr. 502(2), 379-384 (1990). – reference: Mayser, P., Argembeaux, H. and Rippke, F. The hair strand test - a new method for testing anti-fungal effects of anti-dandruff preparations. J. Cosmet. Sci. 54(3), 263-270 (2003). – reference: Trüeb, R.M. Dermocosmetic aspects of hair and scalp. J. Investig. Dermatol. Symp. Proc. 10(3), 289-292 (2005). – reference: Rasband, W.S. ImageJ, U.S. National Institutes of Health, Bethesda, Maryland, USA (19972008), http://rsb.info.nih.gov/ij/ . – reference: Gupta, A.K., Batra, R., Bluhm, R., Boekhout, T. and Dawson Jr, T.L. Skin diseases associated with Malassezia species. J. Am. Acad. Dermatol. 51(5), 785-798 (2004). – reference: Westlake, W.J. Use of confidence intervals in analysis of comparative bioavailability trials. J. Pharm. Sci. 61(8), 1340-1341 (1972). – reference: Wellek, S. Testing Statistical Hypotheses of Equivalence. Chapman & Hall/CRC Press, Boca Raton, Fl. (2003). – reference: Elewski, B.E. Clinical diagnosis of common scalp disorders. J. Investig. Dermatol. Symp. Proc. 10(3), 190-193 (2005). – start-page: 641 year: 1990 end-page: 662 – volume: 32 start-page: 327 year: 1981 end-page: 338 article-title: Evaluation of efficacy of anti‐dandruff agents publication-title: J. Soc Cosmet. Chem. – volume: 111 start-page: 235 issue: 2 year: 1984 end-page: 242 article-title: The aetiology of dandruff and the mode of action of therapeutic agents publication-title: Br. J. Dermatol. – volume: 672 start-page: 27 issue: 1 year: 2009 end-page: 39 article-title: Evaluation of the genotoxicity of the imidazole anti‐fungal climbazole: comparison to published results for other azole compounds publication-title: Mutat. Res. – volume: 10 start-page: 190 issue: 3 year: 2005 end-page: 193 article-title: Clinical diagnosis of common scalp disorders publication-title: J. Investig. Dermatol. Symp. Proc. – volume: 202 start-page: 275 issue: 4 year: 2001 end-page: 282 article-title: The value of hair cosmetics and pharmaceuticals publication-title: Dermatology – volume: 502 start-page: 379 issue: 2 year: 1990 end-page: 384 article-title: High‐performance liquid chromatographic determination of zinc pyrithione in antidandruff preparations based on copper chelate formation publication-title: J. Chromatogr. – volume: 90 start-page: 1346 issue: 33 year: 2001 end-page: 1349 article-title: Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema publication-title: Praxis (Bern 1994) – year: 19972008 – volume: 61 start-page: 1340 issue: 8 year: 1972 end-page: 1341 article-title: Use of confidence intervals in analysis of comparative bioavailability trials publication-title: J. Pharm. Sci. – volume: 22 start-page: 285 issue: 4 year: 2000 end-page: 289 article-title: The anti‐dandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo publication-title: Int J Cosmet Sci. – volume: 10 start-page: 198 issue: 3 year: 2005 end-page: 200 article-title: Product pharmacology and medical actives in achieving therapeutic benefits publication-title: J. Investig. Dermatol. Symp. Proc. – start-page: 259 year: 2004 end-page: 272 – volume: 10 start-page: 289 issue: 3 year: 2005 end-page: 292 article-title: Dermocosmetic aspects of hair and scalp publication-title: J. Investig. Dermatol. Symp. Proc. – year: 2003 – volume: 10 start-page: 201 issue: 3 year: 2005 end-page: 204 article-title: A comparison of hair quality and cosmetic acceptance following the use of two anti‐dandruff shampoos publication-title: J. Investig. Dermatol. Symp. Proc. – volume: 25 start-page: 183 issue: 4 year: 2003 end-page: 188 article-title: A double‐blind randomized vehicle‐controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity publication-title: Int J Cosmet Sci. – volume: 54 start-page: 263 issue: 3 year: 2003 end-page: 270 article-title: The hair strand test ‐ a new method for testing anti‐fungal effects of anti‐dandruff preparations publication-title: J. Cosmet. Sci. – volume: 51 start-page: 785 issue: 5 year: 2004 end-page: 798 article-title: Skin diseases associated with Malassezia species publication-title: J. Am. Acad. Dermatol. – volume: 45 start-page: 3737 issue: 11 year: 2007 end-page: 3742 article-title: Revised culture‐based system for identification of Malassezia species publication-title: J. Clin. Microbiol. – volume-title: Testing Statistical Hypotheses of Equivalence year: 2003 ident: e_1_2_7_14_2 – ident: e_1_2_7_12_2 doi: 10.1016/S0021-9673(01)89602-3 – volume: 90 start-page: 1346 issue: 33 year: 2001 ident: e_1_2_7_21_2 article-title: Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema publication-title: Praxis (Bern 1994) – ident: e_1_2_7_7_2 doi: 10.1111/j.1087-0024.2005.10118.x – volume: 32 start-page: 327 year: 1981 ident: e_1_2_7_20_2 article-title: Evaluation of efficacy of anti‐dandruff agents publication-title: J. Soc Cosmet. Chem. – ident: e_1_2_7_8_2 doi: 10.1016/j.mrgentox.2008.09.011 – ident: e_1_2_7_15_2 doi: 10.1111/j.1087-0024.2005.10127.x – ident: e_1_2_7_19_2 doi: 10.1046/j.1467-2494.2000.00024.x – ident: e_1_2_7_5_2 doi: 10.1111/j.1365-2133.1984.tb04050.x – start-page: 259 volume-title: Textbook of Cosmetic Dermatology year: 2004 ident: e_1_2_7_2_2 – ident: e_1_2_7_9_2 doi: 10.1111/j.1087-0024.2005.10105.x – volume: 54 start-page: 263 issue: 3 year: 2003 ident: e_1_2_7_17_2 article-title: The hair strand test ‐ a new method for testing anti‐fungal effects of anti‐dandruff preparations publication-title: J. Cosmet. Sci. – ident: e_1_2_7_16_2 doi: 10.1046/j.1467-2494.2003.00183.x – ident: e_1_2_7_6_2 doi: 10.1111/j.1087-0024.2005.10103.x – ident: e_1_2_7_13_2 doi: 10.1002/jps.2600610845 – volume-title: ImageJ year: 1997 ident: e_1_2_7_11_2 – ident: e_1_2_7_3_2 doi: 10.1007/978-3-642-74612-3_25 – ident: e_1_2_7_10_2 doi: 10.1128/JCM.01243-07 – ident: e_1_2_7_18_2 doi: 10.1159/000051658 – ident: e_1_2_7_4_2 doi: 10.1016/j.jaad.2003.12.034 |
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Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti‐dandruff shampoo not only has to provide superior... Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti‐dandruff shampoo not only has to provide superior anti‐dandruff... Dandruff is a chronic scalp disorder characterized by scaling and itching. A successful anti-dandruff shampoo not only has to provide superior anti-dandruff... |
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| SubjectTerms | Adolescent Adult Aged Animals Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Applied sciences Chemical industry and chemicals climbazole Cosmetics, toiletries dandruff Dermatitis, Seborrheic - drug therapy Double-Blind Method Drug Combinations Ethanolamines - pharmacology Ethanolamines - therapeutic use Exact sciences and technology Female Hair Preparations - pharmacology Hair Preparations - therapeutic use Humans Imidazoles - pharmacology Imidazoles - therapeutic use Malassezia - growth & development Male Microbial Sensitivity Tests Middle Aged Organometallic Compounds - pharmacology Organometallic Compounds - therapeutic use piroctone olamine Pruritus - drug therapy Pyridines - pharmacology Pyridines - therapeutic use Pyridones - pharmacology Pyridones - therapeutic use shampoo Swine Washing products. Cosmetics and toiletries. Perfumes Young Adult zinc pyrithione |
| Title | Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff |
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