Processing of the FMRFamide precursor protein in the snail Lymnaea stagnalis: characterization and neuronal localization of a novel peptide, 'SEEPLY'

• Published in: The European journal of neuroscience Vol. 5; no. 8; p. 1003
• Main Authors: Santama, N, Li, K W, Bright, K E, Yeoman, M, Geraerts, W P, Benjamin, P R, Burke, J F
• Format: Journal Article
• Language: English
• Published: France 01.08.1993
• Subjects: Amino Acid Sequence; Animals; Central Nervous System - metabolism; FMRFamide; Immunohistochemistry; In Situ Hybridization; Lymnaea - metabolism; Mass Spectrometry; Molecular Sequence Data; Neurons - metabolism; Neuropeptides - chemistry; Neuropeptides - isolation & purification; Neuropeptides - metabolism; Neurotransmitter Agents - metabolism; Protein Precursors - metabolism; Tissue Distribution

In the pulmonate snail Lymnaea stagnalis, FMRFamide-like neuropeptides are encoded by a multi-exon genomic locus which is subject to regulation at the level of mRNA splicing. We aim to understand the post-translational processing of one resulting protein precursor encoding the tetrapeptide FMRFamide...