Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum

• Published in: Journal of labelled compounds & radiopharmaceuticals Vol. 43; no. 3; pp. 261 - 270
• Main Authors: Chen, Bang-Chi, Sundeen, Joseph E., Guo, Peng, Bednarz, Mark S., Hangeland, Jon J., Ahmed, Syed Z., Jemal, Mohammed
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 15.03.2000; Wiley
• Subjects: Analysis; atorvastatin; atorvastatin lactone; Biochemical Research Methods; Biochemistry & Molecular Biology; Biological and medical sciences; Chemistry; Chemistry, Analytical; Chemistry, Medicinal; deuterium; Exact sciences and technology; General pharmacology; Heterocyclic compounds; Heterocyclic compounds with only one n hetero atom and condensed derivatives; hydroxy metabolites; Life Sciences & Biomedicine; Medical sciences; Organic chemistry; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; Preparations and properties; Science & Technology; atorvastatin lactone; hydroxy metabolites; POTENT; PHARMACOKINETICS; deuterium; HEALTHY-SUBJECTS; HMG-COA REDUCTASE; INHIBITOR; atorvastatin; Deuterium; Biological fluid; Diol; Isotope labelling; Nitrogen heterocycle; Metabolite; Internal standard; Pyran derivatives; Lactone; Liquid chromatography; Hydrogen Isotopes; Blood; Pyrrole derivatives; Hydroxyacid; Mass spectrometry MS/MS; Simultaneous measurement; Atorvastatin; Phenols; Carboxamide; Chemical synthesis; Blood serum; Quantitative analysis

D5‐labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5‐Atorvastatin and d5‐at...