Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum - Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed (Journal of labelled compounds & radiopharmaceuticals, 2000)
Keywords: Analysis; atorvastatin; atorvastatin lactone; Biochemical Research Methods; Biochemistry & Molecular Biology; Biological and medical sciences; Chemistry; Chemistry, Analytical; Chemistry, Medicinal; deuterium; Exact sciences and technology; General pharmacology; Heterocyclic compounds; Heterocyclic compounds with only one n hetero atom and condensed derivatives; hydroxy metabolites; Life Sciences & Biomedicine; Medical sciences; Organic chemistry; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; Preparations and properties; Science & Technology; atorvastatin lactone; hydroxy metabolites; POTENT; PHARMACOKINETICS; deuterium; HEALTHY-SUBJECTS; HMG-COA REDUCTASE; INHIBITOR; atorvastatin; Deuterium; Biological fluid; Diol; Isotope labelling; Nitrogen heterocycle; Metabolite; Internal standard; Pyran derivatives; Lactone; Liquid chromatography; Hydrogen Isotopes; Blood; Pyrrole derivatives; Hydroxyacid; Mass spectrometry MS/MS; Simultaneous measurement; Atorvastatin; Phenols; Carboxamide; Chemical synthesis; Blood serum; Quantitative analysis