Inflammatory Biomarkers Predict Heart Failure Severity and Prognosis in Patients With Heart Failure With Preserved Ejection Fraction: A Holistic Proteomic Approach

• Published in: Circulation. Cardiovascular genetics Vol. 10; no. 1; p. e001633
• Main Authors: Hage, Camilla, Michaëlsson, Erik, Linde, Cecilia, Donal, Erwan, Daubert, Jean-Claude, Gan, Li-Ming, Lund, Lars H.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.01.2017; American Heart Association
• Subjects: acute myocardial-infarction; Aged; Aged, 80 and over; apoptosis; association; Bioengineering; biomarkers; Biomarkers - blood; Cardiology and Cardiovascular Disease; Cardiovascular System & Cardiology; comorbidities; Databases, Protein; diastolic; dysfunction; Echocardiography; endothelial dysfunction; Female; France; Genetics & Heredity; growth-differentiation factor-15; Heart Failure - blood; Heart Failure - diagnosis; Heart Failure - mortality; Heart Failure - physiopathology; Humans; inflammation; Inflammation Mediators - blood; Kardiologi och kardiovaskulära sjukdomar; Least-Squares Analysis; Life Sciences; Male; marker; Multivariate Analysis; osteoprotegerin; population; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; proteomics; Proteomics - methods; resolution; Risk Factors; Severity of Illness Index; Stroke Volume; Sweden; Ventricular Function, Left; apoptosis; proteomics; inflammation; prognosis; biomarkers

BACKGROUND—Underlying mechanisms in heart failure (HF) with preserved ejection fraction remain unknown. We investigated cardiovascular plasma biomarkers in HF with preserved ejection fraction and their correlation to diastolic dysfunction, functional class, pathophysiological processes, and prognosi...