Fusogenic Alzheimer'S Peptide Fragment A Beta (29-42) In Interaction With Lipid Bilayers: Secondary Structure, Dynamics, And Specific Interaction With Phosphatidyl Ethanolamine Polar Heads As Revealed By Solid-State Nmr

• Published in: Protein science Vol. 14; no. 5; pp. 1181 - 9
• Main Authors: Ravault, S, Soubias, O, Saurel, O, Thomas, Annick, Brasseur, Robert, Milon, A
• Format: Journal Article Web Resource
• Language: English
• Published: Bristol Cold Spring Harbor Laboratory Press 01.05.2005; Wiley-Blackwell
• Subjects: 2H NMR; 31P NMR relaxation times; Alzheimer; Biochemistry; Biochemistry, biophysics & molecular biology; Biochimie, biophysique & biologie moléculaire; biophysics; Life sciences; lipid dynamics; membrane fusion; molecular biology; POPE; Sciences du vivant

The interaction of the native Alzheimer's peptide C‐terminal fragment Aβ (29–42), and two mutants (G33A and G37A) with neutral lipid bilayers made of POPC and POPE in a 9:1 molar ratio was investigated by solid‐state NMR. This fragment and the lipid composition were selected because they repres...