Roles of paeoniflorin and senkyunolide I in SiWu decoction on antiplatelet and anticoagulation activities
Traditional Chinese medicine (TCM) is a complex system, which consists of numerous compounds with related mechanisms to maximize therapeutic efficacy with minimal adverse effects. Some new methods disclosing the contribution of these constituents as well as their relationship in the formula are nece...
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| Published in | Journal of separation science Vol. 33; no. 21; pp. 3335 - 3340 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
Wiley‐VCH Verlag
01.11.2010
WILEY-VCH Verlag WILEY‐VCH Verlag Wiley |
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| Abstract | Traditional Chinese medicine (TCM) is a complex system, which consists of numerous compounds with related mechanisms to maximize therapeutic efficacy with minimal adverse effects. Some new methods disclosing the contribution of these constituents as well as their relationship in the formula are necessary for elucidating the bio‐active constituents and the working mechanisms of TCM. In this study, depletion of target components using preparative HPLC followed by antiplatelet and anticoagulation activities evaluation was first applied to investigate the roles of paeoniflorin and senkyunolide I in a well‐known formula, SiWu decoction. The results showed that both paeoniflorin and senkyunolide I not only directly brought about some bio‐activities, but also indirectly made the contribution to the total bio‐activity reflection of SiWu decoction, especially the latter should deserve to be drawn attention to the research of complicated bio‐active constituents of TCM or its formula. So, the significant and effective approach will be very useful for the elucidation of the contribution of each different chemical constituent to the bio‐activity of a TCM formula. Furthermore, this study demonstrated the potential utilization of preparative HPLC in the research of TCM. |
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| AbstractList | Abstract
Traditional Chinese medicine (TCM) is a complex system, which consists of numerous compounds with related mechanisms to maximize therapeutic efficacy with minimal adverse effects. Some new methods disclosing the contribution of these constituents as well as their relationship in the formula are necessary for elucidating the bio‐active constituents and the working mechanisms of TCM. In this study, depletion of target components using preparative HPLC followed by antiplatelet and anticoagulation activities evaluation was first applied to investigate the roles of paeoniflorin and senkyunolide I in a well‐known formula, SiWu decoction. The results showed that both paeoniflorin and senkyunolide I not only directly brought about some bio‐activities, but also indirectly made the contribution to the total bio‐activity reflection of SiWu decoction, especially the latter should deserve to be drawn attention to the research of complicated bio‐active constituents of TCM or its formula. So, the significant and effective approach will be very useful for the elucidation of the contribution of each different chemical constituent to the bio‐activity of a TCM formula. Furthermore, this study demonstrated the potential utilization of preparative HPLC in the research of TCM. Traditional Chinese medicine (TCM) is a complex system, which consists of numerous compounds with related mechanisms to maximize therapeutic efficacy with minimal adverse effects. Some new methods disclosing the contribution of these constituents as well as their relationship in the formula are necessary for elucidating the bio-active constituents and the working mechanisms of TCM. In this study, depletion of target components using preparative HPLC followed by antiplatelet and anticoagulation activities evaluation was first applied to investigate the roles of paeoniflorin and senkyunolide I in a well-known formula, SiWu decoction. The results showed that both paeoniflorin and senkyunolide I not only directly brought about some bio-activities, but also indirectly made the contribution to the total bio-activity reflection of SiWu decoction, especially the latter should deserve to be drawn attention to the research of complicated bio-active constituents of TCM or its formula. So, the significant and effective approach will be very useful for the elucidation of the contribution of each different chemical constituent to the bio-activity of a TCM formula. Furthermore, this study demonstrated the potential utilization of preparative HPLC in the research of TCM. |
| Author | Tang, Yuping Qian, Dawei Shang, Erxin Zhu, Min Guo, Sheng Duan, Jin‐ao Ding, Anwei Su, Shulan Guo, Jianming |
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| Copyright | Copyright © 2010 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim 2015 INIST-CNRS |
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| Keywords | Siwu decoction HPLC chromatography Anticoagulant Medicinal plant Folk medicine Dicotyledones Angiospermae Scrophulariaceae Glycoside Terpenoid Purification Aldose Pharmacognosy Preparative chromatography Glucoside Lactone Decoction Senkyunolide I Preparative HPLC In vitro Biological activity Antiplatelet agent Paeoniflorin Depletion Plant origin Isolation Monoterpene Spermatophyta Umbelliferae Paeoniaceae Target components depletion |
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| SubjectTerms | Animals Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anticoagulants - chemistry Anticoagulants - pharmacology Benzoates - chemistry Benzoates - pharmacology Benzofurans - chemistry Benzofurans - pharmacology Biological and medical sciences Bridged-Ring Compounds - chemistry Bridged-Ring Compounds - pharmacology Chromatography, High Pressure Liquid - methods Complex systems Constituents Depletion Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Effectiveness General pharmacology Glucosides - chemistry Glucosides - pharmacology Humans Male Medical sciences Medicine, Chinese Traditional Molecular Structure Monoterpenes Paeoniflorin Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - pharmacology Preparative HPLC Rabbits Reflection Senkyunolide I Separation Siwu decoction Target components depletion Thrombin Time Traditional chinese medicine Utilization |
| Title | Roles of paeoniflorin and senkyunolide I in SiWu decoction on antiplatelet and anticoagulation activities |
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