Programming Fluorogenic DNA Probes for Rapid Detection of Steroids

• Published in: Angewandte Chemie International Edition Vol. 60; no. 28; pp. 15260 - 15265
• Main Authors: Ebrahimi, Sasha B., Samanta, Devleena, Partridge, Benjamin E., Kusmierz, Caroline D., Cheng, Ho Fung, Grigorescu, Arabela A., Chávez, Jorge L., Mirau, Peter A., Mirkin, Chad A.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 05.07.2021
• Edition: International ed. in English
• Subjects: Aptamers; Binding; Complex media; Computer applications; Dehydroepiandrosterone; Dehydroepiandrosterone sulfate; detection; DNA; DNA probes; Fluorescence; forced intercalation; Instrumentation; Recognition; Steroid hormones; Steroids; detection; forced intercalation; steroids; DNA; Aptamers

The ability of aptamers to recognize a variety of different molecules has fueled their emergence as recognition agents to probe complex media and cells. Many detection strategies require aptamer binding to its target to result in a dramatic change in structure, typically from an unfolded to a folded...