RNA versus DNA G‐Quadruplex: The Origin of Increased Stability

• Published in: Chemistry : a European journal Vol. 24; no. 61; pp. 16315 - 16322
• Main Authors: Zaccaria, Francesco, Fonseca Guerra, Célia
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 02.11.2018; John Wiley and Sons Inc
• Subjects: Alkali metals; Aqueous environments; bonding analysis; Cations; Cations - chemistry; Chemistry; Computer simulation; density functional calculations; Density functional theory; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA structures; Electrostatic properties; Electrostatics; G-Quadruplexes; Hydrogen Bonding; Metal ions; Metals, Alkali - chemistry; Models, Molecular; noncovalent interactions; Nucleic Acid Conformation; Organic chemistry; Oxygen atoms; quadruplex; Quantum chemistry; Ribonucleic acid; RNA; RNA - chemistry; RNS structures; Static Electricity; Thermodynamics; density functional calculations; quadruplex; bonding analysis; noncovalent interactions; DNA structures; RNS structures
• ISSN: 0947-6539; 1521-3765; 1521-3765
• DOI: 10.1002/chem.201803530

DNA quadruplexes have been the subject of investigation because of their biological relevance and because of their potential application in supramolecular chemistry. Similarly, RNA quadruplexes are now gaining increasing attention. Although DNA and RNA quadruplexes are structurally very similar, the...