Gene expression profile of papillary thyroid cancer: Sources of variability and diagnostic implications

• Published in: Cancer research (Chicago, Ill.) Vol. 65; no. 4; pp. 1587 - 1597
• Main Authors: JARZAB, Barbara, WIENCH, Malgorzata, PAWLACZEK, Agnieszka, SZPAK, Sylwia, GUBAŁA, Elzbieta, SWIERNIAK, Andrzej, FUJAREWICZ, Krzysztof, SIMEK, Krzysztof, JARZAB, Michal, OCZKO-WOJCIECHOWSKA, Malgorzata, WŁOCH, Jan, CZARNIECKA, Agnieszka, CHMIELIK, Ewa, LANGE, Dariusz
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.02.2005
• Subjects: Adolescent; Adult; Aged; Antineoplastic agents; Biological and medical sciences; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - genetics; Carcinoma, Papillary - metabolism; Child; Child, Preschool; Endocrinopathies; Female; Gene Expression Profiling; Humans; Male; Medical sciences; Middle Aged; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Oligonucleotide Array Sequence Analysis; Pharmacology. Drug treatments; Reproducibility of Results; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid. Thyroid axis (diseases); Endocrinopathy; Thyroid cancer; Variability; Thyroid diseases; Malignant tumor; Diagnosis; Gene expression profile

The study looked for an optimal set of genes differentiating between papillary thyroid cancer (PTC) and normal thyroid tissue and assessed the sources of variability in gene expression profiles. The analysis was done by oligonucleotide microarrays (GeneChip HG-U133A) in 50 tissue samples taken intra...