Research progress on the mechanism of beta-cell apoptosis in type 2 diabetes mellitus

Type 2 diabetes mellitus(T2DM) is regarded as one of the most severe chronic metabolic diseases worldwide, which poses a great threat to human safety and health. The main feature of T2DM is the deterioration of pancreatic beta-cell function. More and more studies have shown that the decline of pancr...

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Published inFrontiers in Endocrinology Vol. 13; p. 976465
Main Authors You, SuFang, Zheng, JingYi, Chen, YuPing, Huang, HuiBin
Format Journal Article
LanguageEnglish
Published Frontiers Media SA 18.08.2022
Frontiers Media S.A
Subjects
apoptosis
beta-cell
Diabetes Mellitus, Type 2
Diseases of the endocrine glands. Clinical endocrinology
Endocrinology
exosomes
glucolipotoxicity
Humans
Insulin-Secreting Cells
non-coding RNAs
Pancreas
RC648-665
type 2 diabetes
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Summary:Type 2 diabetes mellitus(T2DM) is regarded as one of the most severe chronic metabolic diseases worldwide, which poses a great threat to human safety and health. The main feature of T2DM is the deterioration of pancreatic beta-cell function. More and more studies have shown that the decline of pancreatic beta-cell function in T2DM can be attributable to beta-cell apoptosis, but the exact mechanisms of beta-cell apoptosis in T2DM are not yet fully clarified. Therefore, in this review, we will focus on the current status and progress of research on the mechanism of pancreatic beta-cell apoptosis in T2DM, to provide new ideas for T2DM treatment strategies.
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This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology
Reviewed by: Hiroshi Nomoto, Hokkaido University Hospital, Japan; Ismail Syed, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, United States; Sho Osonoi, Hirosaki University, Japan
Edited by: Hiroki Mizukami, Hirosaki University, Japan
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.976465